Philadelphia 76ers vs Cleveland Cavaliers Prediction & Picks - NBA
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by Paul Tamayo in NBA Picks
The Cleveland Cavaliers (23-19) visit the Philadelphia 76ers (22-17) in an NBA 2025-26 game on Friday, January 16, at the Xfinity Mobile Arena.
The Sixers look to avenge a stinging defeat on their home floor when they host the Cavaliers for the second time in three days. Recently, they suffered a lopsided 133-107 loss to this same Cleveland squad on Wednesday night. The Sixers trailed for most of the contest, unable to contain Cleveland's perimeter shooting.
So far this season, the Sixers have lost their two matchups against the Cavaliers. They have also lost two of their last three games, although the good news is they're relatively healthier at this stage of the year.
Joel Embiid, Paul George, and Dominick Barlow are listed as day-to-day in the team's injury report, but it's highly expected that they'll play on Friday.
As for the Cavaliers, they're coming off that dominant victory in Philadelphia two days ago. Their offense was firing on all cylinders in that win, led by Donovan Mitchell, who exploded for 35 points, 7 rebounds, and 9 assists.
Cleveland also made 20 of their 46 tries from the three-point line, arguably the X-factor in that win against Philly.
Darius Garland, Sam Merrill, Max Strus, and Dean Wade won't suit up for the Cavs on Friday.
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Philadelphia 76ers vs Cleveland Cavaliers Form
Table
| Teams | % | P | W | L | Series |
|---|---|---|---|---|---|
|
13
|
0.558 | 43 | 24 | 19 | 2 |
|
14
|
0.55 | 40 | 22 | 18 |
Philadelphia 76ers and Cleveland Cavaliers Latest Matches
3/6 (50%)
3/6 (50%)
Jan 16, 2026 - NBA
Jan 14, 2026 - NBA
Jan 12, 2026 - NBA
Jan 11, 2026 - NBA
Jan 9, 2026 - NBA
Jan 7, 2026 - NBA
2/6 (33%)
4/6 (67%)
Jan 16, 2026 - NBA
Jan 14, 2026 - NBA
Jan 7, 2026 - NBA
Jan 5, 2026 - NBA
Dec 23, 2025 - NBA
Dec 20, 2025 - NBA
5/6 (83%)
1/6 (17%)
Jan 12, 2026 - NBA
Jan 11, 2026 - NBA
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Jan 1, 2026 - NBA
Dec 30, 2025 - NBA
4/6 (67%)
2/6 (33%)
Jan 16, 2026 - NBA
Jan 14, 2026 - NBA
Jan 12, 2026 - NBA
Jan 10, 2026 - NBA
Jan 8, 2026 - NBA
Jan 6, 2026 - NBA
4/6 (67%)
2/6 (33%)
Jan 12, 2026 - NBA
Jan 10, 2026 - NBA
Jan 4, 2026 - NBA
Jan 2, 2026 - NBA
Dec 31, 2025 - NBA
Dec 23, 2025 - NBA
4/6 (67%)
2/6 (33%)
Jan 16, 2026 - NBA
Jan 14, 2026 - NBA
Jan 8, 2026 - NBA
Jan 6, 2026 - NBA
Dec 29, 2025 - NBA
Dec 27, 2025 - NBA
Philadelphia 76ers against Cleveland Cavaliers : Head to Head (H2H)
17 %
83 %
Jan 16, 2026 - NBA
Jan 14, 2026 - NBA
Nov 5, 2025 - NBA
Jan 24, 2025 - NBA
Dec 21, 2024 - NBA
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Players list
T. Maxey
V. Edgecombe
ForwardD. Barlow
P. George
D. Garland
D. Mitchell
ForwardE. Mobley
J. Tyson
Substitutes
J. McCain
J. Edwards
Q. Grimes
E. Gordon
K. Lowry
ForwardT. Watford
J. Walker
C. Porter
T. Proctor
L. Ball
S. Merrill
ForwardN. Tomlin
Philadelphia 76ers - Cleveland Cavaliers Key Points
- The Cavaliers defeated the Sixers, 133-107, last Wednesday.
- The Cavaliers have won their first two games against the Sixers this season.
- The Cavaliers have a better offensive rating than the Sixers.
- The Sixers have lost two of their last three games.
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Our Philadelphia 76ers vs Cleveland Cavaliers Prediction
The Sixers might be fully healthy for Friday's rematch against the Cavaliers, something that's crucial for their playoff push. They're the slight favorites to win, especially if Joel Embiid and Paul George shake off their minor injuries.
However, Donovan Mitchell and the Cavaliers have had their number this season. If the Cavaliers shoot the lights out again like they did on Wednesday, this might be another loss for the Sixers. Our prediction for the Philadelphia 76ers vs Cleveland Cavaliers match is: Cavaliers (+1.5) cover the spread.Grab an extra $300 for your Philadelphia 76ers vs Cleveland Cavaliers wager!
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
