Chicago Bears vs San Francisco 49ers Prediction & Picks - NFL

USA - NFL

Chicago Bears
12/28/25 20:20
San Francisco 49ers

Prediction:

 

San Francisco -3

-110
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Bill Christy in NFL Picks

Two of the top teams in the NFC will collide on Sunday Night at Levi’s Stadium. The San Francisco 49ers (11-4) will host the Chicago Bears (11-4). Both teams are fighting to improve their spot in the NFC standings for the playoffs. Chicago also has the best chance at securing their division as well.

San Francisco is on a 5-game winning streak and coming off a 48-27 win over the Colts, in which Brock Purdy looked to be in the best form of the season. He finished with 295 passing yards, completed 73.5% of his passes, and tossed 5 touchdowns. Christian McCaffery chimed in with 117 yards on the ground and scored twice on catches from Purdy. This 49er team is one of the most complete teams in the NFC and has an offense scoring inside the top 10, while their defense is just outside at 11th in points allowed per game.

Chicago has been the surprise of the season. They are currently in 2nd place in the entire conference and have won 7 of their last 8 games. Their most recent win came over their division rivals, the Green Bay Packers. The Chicago offense was humming and finished with 400 total yards. On the season, Caleb Williams has not been all that impressive. However, he is not turning the ball over, which is all the offense has really needed.

This game should play like a playoff game due to all the implications it holds. And on paper, the matchup is as even as possible. Miscues and/or turnovers will play big roles in this matchup which could be an NFC Championship Game preview

Chicago Bears vs San Francisco 49ers Form

Table

Teams % P W D L
7
San Francisco 49ers
San Francisco 49ers
0.733 15 11 0 4
8
Chicago Bears
Chicago Bears
0.733 15 11 0 4

Chicago Bears and San Francisco 49ers Latest Matches

Chicago Bears
Chicago Bears Latest matches
W W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Dec 20, 2025 - NFL

Green Bay Packers
16 :  22
Chicago Bears

Dec 14, 2025 - NFL

Cleveland Browns
3 :  31
Chicago Bears

Dec 7, 2025 - NFL

Chicago Bears
21 :  28
Green Bay Packers

Nov 28, 2025 - NFL

Chicago Bears
24 :  15
Philadelphia Eagles

Nov 23, 2025 - NFL

Pittsburgh Steelers
28 :  31
Chicago Bears

Nov 16, 2025 - NFL

Chicago Bears
19 :  17
Minnesota Vikings
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Dec 20, 2025 - NFL

Green Bay Packers
16 :  22
Chicago Bears

Dec 14, 2025 - NFL

Cleveland Browns
3 :  31
Chicago Bears

Nov 23, 2025 - NFL

Pittsburgh Steelers
28 :  31
Chicago Bears

Nov 9, 2025 - NFL

New York Giants
20 :  24
Chicago Bears

Oct 19, 2025 - NFL

New Orleans Saints
14 :  26
Chicago Bears

Sep 21, 2025 - NFL

Dallas Cowboys
14 :  31
Chicago Bears
W L W W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 7, 2025 - NFL

Chicago Bears
21 :  28
Green Bay Packers

Nov 28, 2025 - NFL

Chicago Bears
24 :  15
Philadelphia Eagles

Nov 16, 2025 - NFL

Chicago Bears
19 :  17
Minnesota Vikings

Nov 2, 2025 - NFL

Chicago Bears
47 :  42
Cincinnati Bengals

Oct 26, 2025 - NFL

Chicago Bears
16 :  30
Baltimore Ravens

Oct 13, 2025 - NFL

Chicago Bears
25 :  24
Washington Commanders
San Francisco 49ers
San Francisco 49ers Latest matches
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Dec 22, 2025 - NFL

San Francisco 49ers
48 :  27
Indianapolis Colts

Dec 14, 2025 - NFL

Tennessee Titans
24 :  37
San Francisco 49ers

Nov 30, 2025 - NFL

San Francisco 49ers
26 :  8
Cleveland Browns

Nov 24, 2025 - NFL

Carolina Panthers
9 :  20
San Francisco 49ers

Nov 16, 2025 - NFL

San Francisco 49ers
41 :  22
Arizona Cardinals

Nov 9, 2025 - NFL

Los Angeles Rams
42 :  26
San Francisco 49ers
W L W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 14, 2025 - NFL

Tennessee Titans
24 :  37
San Francisco 49ers

Nov 24, 2025 - NFL

Carolina Panthers
9 :  20
San Francisco 49ers

Nov 9, 2025 - NFL

Los Angeles Rams
42 :  26
San Francisco 49ers

Oct 19, 2025 - NFL

Atlanta Falcons
10 :  20
San Francisco 49ers

Sep 28, 2025 - NFL

Jacksonville Jaguars
26 :  21
San Francisco 49ers

Sep 21, 2025 - NFL

Arizona Cardinals
15 :  16
San Francisco 49ers
L L W W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 22, 2025 - NFL

San Francisco 49ers
48 :  27
Indianapolis Colts

Nov 30, 2025 - NFL

San Francisco 49ers
26 :  8
Cleveland Browns

Nov 16, 2025 - NFL

San Francisco 49ers
41 :  22
Arizona Cardinals

Nov 2, 2025 - NFL

San Francisco 49ers
34 :  24
New York Giants

Oct 26, 2025 - NFL

San Francisco 49ers
15 :  26
Houston Texans

Oct 12, 2025 - NFL

San Francisco 49ers
19 :  30
Tampa Bay Buccaneers

Chicago Bears against San Francisco 49ers : Head to Head (H2H)

Chicago Bears

0 %

Draw

0 %

San Francisco 49ers

100 %

Dec 8, 2024 - NFL

Chicago Bears
13 :  38
San Francisco 49ers

Oct 31, 2021 - NFL

San Francisco 49ers
33 :  22
Chicago Bears

Chicago Bears - San Francisco 49ers Key Points

  1. Chicago is 9-24-1 ATS in its last 34 games played on a Sunday when playing on the road.
  2. Chicago is 2-9 ATS in its last 11 games when playing on the road against San Francisco.
  3. San Francisco is 6-1 ATS in its last 7 games.
  4. San Francisco is 6-0 ATS in its last 6 games when playing as the favorite.

Our Chicago Bears vs San Francisco 49ers Prediction

The public is finally buying into this Chicago team. 60% of their tickets are currently on the Bears, and we will be happy to fade them in this spot. Last week, we saw Purdy and company finally put everything together on offense. While this Bears defense is certainly better than the Colts', the total is over 50 points. Both offenses should shine, but we are going to back the one we feel is much hotter now.

Our prediction for San Francisco 49ers vs Chicago Bears: San Francisco -3

Prediction:

 

San Francisco -3

-110
$200 offered for betting!

Deposit Bonus Up To $1,000

DK Dollars

Looking for some extra boost for your Chicago Bears vs San Francisco 49ers pick? New users are in luck as DraftKings is offering a deposit bonus now and for a limited time only! First deposits to your DK sportsbook account are rewarded with a bonus of up to $1,000! Be sure to check the full terms and conditions to ensure you're eligible.

Available for Chicago Bears vs San Francisco 49ers

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Chicago Bears vs San Francisco 49ers Picks