Carolina Panthers vs Arizona Cardinals Prediction & Picks - NFL

USA - NFL

Carolina Panthers
9/14/25 16:05
Arizona Cardinals

Prediction:

 

The Cardinals -6.5 Points

-115
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 by Lou Aguila in NFL Picks

The Carolina Panthers are marching in as road underdogs (+240) against the team they have beaten in 7 out of their last 10 meetings, the Arizona Cardinals (-298), on Sunday at State Farm Stadium.

Current Form:

The Panthers lost their season-opening match against the Jacksonville Jaguars 10-26 last week. Quarterback Bryce Young completed only 18 of 35 passes for 154 yards with one touchdown and two interceptions as Carolina’s offensive line could not contain the Jaguars' aggressive pass rushing. The Panthers also failed to make an impact on the ground, covering only 113 rushing yards without a TD. Running back Chuba Hubbard ran the longest for Carolina at 16 yards, finishing the match with a team-high 54 yards.

The Cardinals fended off a late rally from the New Orleans Saints to hold on to a 20-13 win in Week 1. Arizona quarterback Kyle Murray covered 162 passing yards (21-for-29) with two touchdowns and no interceptions, while Trey Benson rushed for 69 yards. Arizona conceded 315 total yards, but allowed the Saints to convert only one of four attempts in the red zone.

Carolina Panthers vs Arizona Cardinals Form

Table

Teams % P W D L
10
Arizona Cardinals
Arizona Cardinals
1 1 1 0 0
29
Carolina Panthers
Carolina Panthers
0 1 0 0 1

Carolina Panthers and Arizona Cardinals Latest Matches

Carolina Panthers
Carolina Panthers Latest matches
L L W L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 7, 2025 - NFL

Carolina Panthers
10 :  26
Jacksonville Jaguars

Jan 5, 2025 - NFL

Carolina Panthers
44 :  38
Atlanta Falcons

Dec 29, 2024 - NFL

Carolina Panthers
14 :  48
Tampa Bay Buccaneers

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers

Dec 15, 2024 - NFL

Dallas Cowboys
30 :  14
Carolina Panthers

Dec 8, 2024 - NFL

Carolina Panthers
16 :  22
Philadelphia Eagles
W W L L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers

Dec 15, 2024 - NFL

Dallas Cowboys
30 :  14
Carolina Panthers

Dec 1, 2024 - NFL

Tampa Bay Buccaneers
26 :  23
Carolina Panthers

Nov 24, 2024 - NFL

Kansas City Chiefs
30 :  27
Carolina Panthers

Nov 10, 2024 - NFL

New York Giants
17 :  20
Carolina Panthers

Nov 3, 2024 - NFL

New Orleans Saints
22 :  23
Carolina Panthers
L L L L W L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Sep 7, 2025 - NFL

Carolina Panthers
10 :  26
Jacksonville Jaguars

Jan 5, 2025 - NFL

Carolina Panthers
44 :  38
Atlanta Falcons

Dec 29, 2024 - NFL

Carolina Panthers
14 :  48
Tampa Bay Buccaneers

Dec 8, 2024 - NFL

Carolina Panthers
16 :  22
Philadelphia Eagles

Oct 27, 2024 - NFL

Carolina Panthers
14 :  28
Denver Broncos

Oct 20, 2024 - NFL

Carolina Panthers
7 :  40
Washington Commanders
Arizona Cardinals
Arizona Cardinals Latest matches
L W L L W W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 7, 2025 - NFL

Arizona Cardinals
20 :  13
New Orleans Saints

Jan 5, 2025 - NFL

San Francisco 49ers
24 :  47
Arizona Cardinals

Dec 28, 2024 - NFL

Arizona Cardinals
9 :  13
Los Angeles Rams

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers

Dec 15, 2024 - NFL

New England Patriots
17 :  30
Arizona Cardinals

Dec 8, 2024 - NFL

Seattle Seahawks
30 :  18
Arizona Cardinals
W W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Jan 5, 2025 - NFL

San Francisco 49ers
24 :  47
Arizona Cardinals

Dec 15, 2024 - NFL

New England Patriots
17 :  30
Arizona Cardinals

Dec 8, 2024 - NFL

Seattle Seahawks
30 :  18
Arizona Cardinals

Nov 10, 2024 - NFL

New York Jets
6 :  31
Arizona Cardinals

Nov 3, 2024 - NFL

Chicago Bears
9 :  29
Arizona Cardinals

Oct 21, 2024 - NFL

Los Angeles Chargers
15 :  17
Arizona Cardinals
W L L L L W
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 7, 2025 - NFL

Arizona Cardinals
20 :  13
New Orleans Saints

Dec 28, 2024 - NFL

Arizona Cardinals
9 :  13
Los Angeles Rams

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers

Dec 1, 2024 - NFL

Arizona Cardinals
22 :  23
Minnesota Vikings

Nov 24, 2024 - NFL

Arizona Cardinals
6 :  16
Seattle Seahawks

Oct 27, 2024 - NFL

Arizona Cardinals
28 :  27
Miami Dolphins

Carolina Panthers against Arizona Cardinals : Head to Head (H2H)

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers

Carolina Panthers - Arizona Cardinals Key Points

  1. Arizona is 5-1 ATS in its last 6 games at home.
  2. Arizona is 2-5 SU in its last 7 games against an opponent in the National Football Conference
  3. Carolina is 2-16 SU in its last 18 games on the road.
  4. Carolina is 1-5 ATS in its last 6 games played in September.

Our Carolina Panthers vs Arizona Cardinals Prediction

Bet on the Cardinals to win and cover -6.5 points against the Panthers, who are 2-16 in their last 18 games on the road. Never mind that Arizona is 1-7 in its last 8 meetings with Carolina. The Cardinals showed in their season-opening game against the Saints that they can hold their ground in the red zone. Kyle Murray will only get better in Week 2 after throwing for 162 yards despite feeling ill the morning before the match. As for Bryce Young, he would have to take his game to another level if he wants to lead his team to an upset on the road. Young covered 154 yards in the first game against the Jaguars, but he still ended up with a quarterback rating of 25.0 after throwing two interceptions.

Barring a meltdown, Arizona should take care of its business against the Panthers. Expect Murray to top his week 1 performance with a more tantalizing stats line against the Carolina defense that is projected to be mediocre this season.

Our betting prediction for Arizona Cardinals vs. the Carolina Panthers: the Cardinals -6.5 points.

Prediction:

 

The Cardinals -6.5 Points

-115
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Carolina Panthers vs Arizona Cardinals Picks