Anastasia Zakharova vs Camila Osorio Prediction & Picks - WTA Mutua Madrid Open

WTA - WTA Mutua Madrid Open

WTA 85
Anastasia Zakharova
4/21/26 11:55
WTA 68 Colombia
Camila Osorio

Prediction:

 

Anastasia Zakharova +4,5 Games

-140
$250 offered for betting!

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 by Lou Aguila | in Tennis Picks

Anastasia Zakharova will attempt to cover the spread with a +4.5-game cushion against Camila Osorio, who is licking her wounds after the second-round exit in her home tournament in Bogota.

Momentum: Camilo Osorio is set to kick off her campaign in Madrid after a shocking round-of-16 exit in her home tournament in Bogota. After a promising start to her 2026 season, Osorio has somewhat hit the wall in the past weeks, going 2-3 in her last five matches. Osorio is 9-6 on the season.

After reaching the third round at the 2026 Miami Open, Anastasia Zakharova bombed out in the first round of the 2026 Charleston Open, losing to Dayana Yastremska 7-5, 6-2. Zakharova is 13-10 in 2026.

The Matchup: Camila Osorio defeated Anastasia Zakharova 6-0, 4-6, 6-3 in the first meeting at the 2024 Birmingham Open. Osorio carries a 70 percent win rate on clay into her second duel with Zakharova, who boasts a decent 57 percent win rate on clay.

Hot on the Board: Osorio is the clear-cut favorite at -260 moneyline and +100 to cover -4.5 games. Zakharova is +190 if she can pull off an upset and -140 to cover +4.5 games.

Up to $250 to bet on Anastasia Zakharova - Camila Osorio! 

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Anastasia Zakharova vs Camila Osorio Form

Anastasia Zakharova and Camila Osorio Latest Matches

Anastasia Zakharova Latest matches
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Mar 30, 2026 - WTA Charleston Open

Anastasia Zakharova
0 :  2
Dayana Yastremska

Mar 21, 2026 - WTA Miami

Anastasia Zakharova
0 :  2
Victoria Mboko

Mar 20, 2026 - WTA Miami

Anna Kalinskaya
1 :  2
Anastasia Zakharova

Mar 19, 2026 - WTA Miami

Anastasia Zakharova
2 :  1
Anna Bondar

Mar 17, 2026 - WTA Miami

Anastasia Zakharova
2 :  0
Rebecca Sramkova

Mar 16, 2026 - WTA Miami

Anastasia Zakharova
2 :  0
Louisa Chirico
Camila Osorio Latest matches
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 2, 2026 - WTA Bogota

Camila Osorio
0 :  2
Jazmin Ortenzi

Mar 31, 2026 - WTA Bogota

Camila Osorio
2 :  1
Caroline Dolehide

Mar 20, 2026 - WTA Miami

Karolina Muchova
2 :  1
Camila Osorio

Mar 17, 2026 - WTA Miami

Katerina Siniakova
0 :  2
Camila Osorio

Mar 8, 2026 - WTA Indian Wells

Camila Osorio
1 :  2
Naomi Osaka

Mar 6, 2026 - WTA Indian Wells

Iva Jovic
1 :  2
Camila Osorio

Anastasia Zakharova - Camila Osorio Key Points

  1. Anastasia Zakharova owns a 57 percent win rate on the clay court
  2. Anastasia Zakharova is 18-34 vs. the top-100 players
  3. Camila Osorio lost in the second round of the 2026 250 Bogota
  4. Camila Osorio is 2-3 in her last top-5.
Up to $250 to bet on Anastasia Zakharova - Camila Osorio! 

Limited Offer. Currently at Caesars Sportsbook

Our Anastasia Zakharova vs Camila Osorio Prediction

Fearless Forecast: Camila Osorio fends off Anastasia Zakharova 6-4, 7-6

The Edge: With a 70 percent win rate on clay, Osorio is a no-brainer pick to win straight-up in this match. Osorio’s three titles on the WTA Tour came on the clay, so it’s understandable why the majority of bettors are picking her to win straight-up despite coming off a disastrous stint in Bogota.

The Bet: Back Anastasia Zakharova to cover +4.5 games for the reason that Osorio is coming into the tournament with zero form at all on clay. Osorio competed in her home tournament in Bogota, gunning for a deep run and coming out with a sharper form in time for the big tournaments in the clay-court swing. Instead, the 6-7, 6-7 loss to Jazmin Ortenzi of Argentina in the second round of that event exposed a lot of flaws in her game and certainly hurt her confidence that she worked hard to build early this season.

Ranked 79th in the world, Zakharova is nowhere near a pushover foe. The Russian owns 18 career wins against top-100 players and a winning record of 87-46 in first-round matches. In short, she will present headaches for Osorio, who will try to rebuild momentum all over again.

Our betting prediction for Anastasia Zakharova vs. Camila Osorio: Anastasia Zakharova +4.5 Games

Prediction:

 

Anastasia Zakharova +4,5 Games

-140
$250 offered for betting!

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Anastasia Zakharova vs Camila Osorio Picks