Washington Wizards vs Milwaukee Bucks Prediction & Picks - NBA

Prediction published on 10/22/25, 4:20 PM  by Lou Aguila in NBA Picks

The Milwaukee Bucks will open the 2025-26 NBA season against the lowly Washington Wizards at Fiserv Forum on Wednesday.

The Bucks are massive favorites in this matchup at -350 on DraftKings, but you could win a decent amount of cash if you bet on Giannis Antetokounmpo to put up a monster statistical line on opening night.

Right now, the Bucks superstar is valued at a generous +152 on a 55+ player combo prop (points + rebounds + assists). That’s a payout of $252 on a $100 bet if Giannis accumulates more than 55 statistical points from combined points, rebounds, and assists.

Current Form:

The Bucks begin another title hunt this week, featuring a more loaded frontline than they had in the previous season. Milwaukee is about to unleash its new Big 3 of Giannis Antetokounmpo, Kyle Kuzma, and new center Myles Turner, parading a long but versatile starting bigs for this Eastern Conference contender. The Bucks wrapped up their preseason with a 3-1 record. They picked up wins over Miami 103-93, Detroit 117-111 and Chicago 127-121 before losing to the defending NBA champion, the OKC Thunder 112-116, in the finale.

The Wizards finished with a 1-2 record in their preseason schedule, with their lone win of the exhibitions coming against the New York Knicks. Not much is expected from Washington this year. The 2025-26 season will continue to be a rebuilding year for the Wizards, who will be bannered by veterans Khris Middleton, CJ McCollum, and former No.2 overall pick Alex Sarr.