St. Louis Cardinals vs Washington Nationals Prediction & Picks - MLB

USA - MLB

St. Louis Cardinals
9/18/26 20:15
Washington Nationals

Prediction:

 

The Cardinals will win

-108
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 by Lou Aguila in MLB Picks

8-2 against the Washington Nationals in their head-to-head series, the St. Louis Cardinals will try to reassert their dominance in Game 1.

Current Form:

The St. Louis Cardinals have lost 3 of their last 5 games, dropping to 75-78 in the season. Over their last five games, the Cardinals have averaged 3.7 runs and posted a 3.72 ERA.

Meanwhile, the Washington Nationals’ 4-game winning streak came to an end at the hands of the Philadelphia Phillies, 0-3. After scoring 6 runs in three straight games, the Nats went scoreless in Game 3 against the Phillies as Zack Wheeler dominated through 7 innings.

Starting Pitchers: Cardinals RHP Kyle Leahy (10-4, 3.33 ERA) vs. Nationals RHP Cade Cavalli (12-5, 3.12 ERA).

The Matchup: The Cardinals have won 8 of their last 10 meetings with the Nationals.

St. Louis Cardinals vs Washington Nationals Form

Table

Teams Pts P W L
18 St. Louis Cardinals
0.49 153 75 78
21 Washington Nationals
0.464 153 71 82

St. Louis Cardinals and Washington Nationals Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 16, 2026 - MLB

St. Louis Cardinals
5 :  6
San Francisco Giants

Sep 15, 2026 - MLB

St. Louis Cardinals
3 :  10
San Francisco Giants

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants

Sep 13, 2026 - MLB

St. Louis Cardinals
3 :  1
Chicago White Sox

Sep 12, 2026 - MLB

St. Louis Cardinals
5 :  6
Chicago White Sox

Sep 11, 2026 - MLB

St. Louis Cardinals
7 :  3
Chicago White Sox
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 16, 2026 - MLB

St. Louis Cardinals
5 :  6
San Francisco Giants

Sep 15, 2026 - MLB

St. Louis Cardinals
3 :  10
San Francisco Giants

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants

Sep 13, 2026 - MLB

St. Louis Cardinals
3 :  1
Chicago White Sox

Sep 12, 2026 - MLB

St. Louis Cardinals
5 :  6
Chicago White Sox

Sep 11, 2026 - MLB

St. Louis Cardinals
7 :  3
Chicago White Sox
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals

Sep 7, 2026 - MLB

San Francisco Giants
5 :  4
St. Louis Cardinals

Sep 6, 2026 - MLB

Colorado Rockies
8 :  10
St. Louis Cardinals

Sep 5, 2026 - MLB

Colorado Rockies
10 :  7
St. Louis Cardinals

Sep 4, 2026 - MLB

Colorado Rockies
6 :  7
St. Louis Cardinals
Washington Nationals
Washington Nationals Latest matches
L W W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 16, 2026 - MLB

Washington Nationals
0 :  3
Philadelphia Phillies

Sep 15, 2026 - MLB

Washington Nationals
6 :  3
Philadelphia Phillies

Sep 13, 2026 - MLB

Washington Nationals
6 :  5
Los Angeles Angels

Sep 12, 2026 - MLB

Washington Nationals
6 :  5
Los Angeles Angels

Sep 11, 2026 - MLB

Washington Nationals
4 :  3
Los Angeles Angels

Sep 9, 2026 - MLB

San Diego Padres
9 :  2
Washington Nationals
L W W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 16, 2026 - MLB

Washington Nationals
0 :  3
Philadelphia Phillies

Sep 15, 2026 - MLB

Washington Nationals
6 :  3
Philadelphia Phillies

Sep 13, 2026 - MLB

Washington Nationals
6 :  5
Los Angeles Angels

Sep 12, 2026 - MLB

Washington Nationals
6 :  5
Los Angeles Angels

Sep 11, 2026 - MLB

Washington Nationals
4 :  3
Los Angeles Angels

Sep 2, 2026 - MLB

Washington Nationals
0 :  9
Atlanta Braves
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 9, 2026 - MLB

San Diego Padres
9 :  2
Washington Nationals

Sep 8, 2026 - MLB

San Diego Padres
5 :  4
Washington Nationals

Sep 7, 2026 - MLB

San Diego Padres
3 :  2
Washington Nationals

Sep 6, 2026 - MLB

Los Angeles Dodgers
7 :  5
Washington Nationals

Sep 5, 2026 - MLB

Los Angeles Dodgers
6 :  5
Washington Nationals

Sep 4, 2026 - MLB

Los Angeles Dodgers
5 :  3
Washington Nationals

St. Louis Cardinals against Washington Nationals : Head to Head (H2H)

St. Louis Cardinals

67 %

Washington Nationals

33 %

Apr 8, 2026 - MLB

Washington Nationals
1 :  6
St. Louis Cardinals

Apr 7, 2026 - MLB

Washington Nationals
6 :  7
St. Louis Cardinals

Apr 6, 2026 - MLB

Washington Nationals
9 :  6
St. Louis Cardinals

Mar 19, 2026 - MLB Spring Training

St. Louis Cardinals
5 :  1
Washington Nationals

Mar 17, 2026 - MLB Spring Training

Washington Nationals
1 :  0
St. Louis Cardinals

Mar 15, 2026 - MLB Spring Training

St. Louis Cardinals
6 :  3
Washington Nationals
St. Louis Cardinals vs Washington Nationals Picks

St. Louis Cardinals - Washington Nationals Key Points

  1. The Cardinals are 42-33 in their road games against the spread
  2. The Cardinals are 2-3 in their last 5 games against the spread
  3. The Nationals are 1-4 in their last 5 games against the spread
  4. The Nationals are 2-8 in their last 10 meetings with the Cardinals.

Our St. Louis Cardinals vs Washington Nationals Prediction

Key Stats: Leahy has posted three shutouts in his last five starts and commanded a 3.06 ERA in this stretch. Cavalli has registered a 1.93 ERA over his last five starts, but the Nats bullpen has surrendered a 4.61 ERA this season.

What to Expect: The Cardinals assert their mastery over the Nats. The Cardinals have always found ways to beat the Nats based on their recent head-to-head record. There won’t be an exception on Friday as St. Louis turns to one of their best pitchers this season, Kyle Leahy.

This game has the potential to be a low-scoring affair since it will feature a Leahy-Cavalli battle, but the Cardinals should come through with clutch plays down the stretch.

Fearless Forecast: The Cardinals 3, the Nats 2

Our betting prediction for the St. Louis Cardinals vs. the Washington Nationals: The Cardinals will win

Prediction:

 

The Cardinals will win

-108
$200 offered for betting!

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