Chicago White Sox vs Washington Nationals Prediction & Picks - MLB

USA - MLB

Chicago White Sox
4/25/26 16:10
Washington Nationals

Prediction:

 

White Sox ML

-140
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 by Travis Pulver | in MLB Picks

The Chicago White Sox (11-15, 4-6 Home) will try to build off their recent success when they host the Washington Nationals today in Game Two of a three-game weekend series. Fans can follow the action from Rate Field in Chicago, IL, on MLB.TV once the game gets underway at 4:10 p.m. EST.

Chicago returned home yesterday after a successful road trip that saw them beat the Athletics and Diamondbacks, 2-1, in each series. The good times continued with the White Sox winning a competitive game with a go-ahead sacrifice fly by Sam Antonacci in the bottom of the eighth inning.

Noah Schultz is scheduled to start for the White Sox on the mound today. Schultz is 1-1 in two starts with a 3.86 ERA and .96 WHIP. The White Sox have not asked him to go too far into a game yet; he went 4 1/3 in his first start (April 14 vs. Tampa Bay) and 5 in his second (April 19 vs. the Athletics). As for Nationals starter Jake Irvin, he has gone 1-3 in five starts with a 6.00 ERA and a 1.29 WHIP. He, too, has not gone deep into games, lasting five innings in four of five starts.


 

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Chicago White Sox vs Washington Nationals Form

Table

Teams Pts P W L
8 Chicago White Sox
0.531 81 43 38
13 Washington Nationals
0.5 84 42 42

Chicago White Sox and Washington Nationals Latest Matches

Chicago White Sox
Chicago White Sox Latest matches
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 24, 2026 - MLB

Chicago White Sox
5 :  4
Washington Nationals

Apr 23, 2026 - MLB

Arizona Diamondbacks
1 :  4
Chicago White Sox

Apr 22, 2026 - MLB

Arizona Diamondbacks
11 :  7
Chicago White Sox

Apr 21, 2026 - MLB

Arizona Diamondbacks
5 :  11
Chicago White Sox

Apr 19, 2026 - MLB

Athletics
4 :  7
Chicago White Sox

Apr 18, 2026 - MLB

Athletics
7 :  6
Chicago White Sox
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 24, 2026 - MLB

Chicago White Sox
5 :  4
Washington Nationals

Apr 16, 2026 - MLB

Chicago White Sox
3 :  5
Tampa Bay Rays

Apr 15, 2026 - MLB

Chicago White Sox
3 :  8
Tampa Bay Rays

Apr 14, 2026 - MLB

Chicago White Sox
5 :  8
Tampa Bay Rays

Apr 8, 2026 - MLB

Chicago White Sox
3 :  5
Baltimore Orioles

Apr 7, 2026 - MLB

Chicago White Sox
2 :  4
Baltimore Orioles
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 23, 2026 - MLB

Arizona Diamondbacks
1 :  4
Chicago White Sox

Apr 22, 2026 - MLB

Arizona Diamondbacks
11 :  7
Chicago White Sox

Apr 21, 2026 - MLB

Arizona Diamondbacks
5 :  11
Chicago White Sox

Apr 19, 2026 - MLB

Athletics
4 :  7
Chicago White Sox

Apr 18, 2026 - MLB

Athletics
7 :  6
Chicago White Sox

Apr 17, 2026 - MLB

Athletics
2 :  9
Chicago White Sox
Washington Nationals
Washington Nationals Latest matches
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 24, 2026 - MLB

Chicago White Sox
5 :  4
Washington Nationals

Apr 23, 2026 - MLB

Washington Nationals
2 :  7
Atlanta Braves

Apr 22, 2026 - MLB

Washington Nationals
6 :  8
Atlanta Braves

Apr 21, 2026 - MLB

Washington Nationals
11 :  4
Atlanta Braves

Apr 20, 2026 - MLB

Washington Nationals
4 :  9
Atlanta Braves

Apr 19, 2026 - MLB

Washington Nationals
3 :  0
San Francisco Giants
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 23, 2026 - MLB

Washington Nationals
2 :  7
Atlanta Braves

Apr 22, 2026 - MLB

Washington Nationals
6 :  8
Atlanta Braves

Apr 21, 2026 - MLB

Washington Nationals
11 :  4
Atlanta Braves

Apr 20, 2026 - MLB

Washington Nationals
4 :  9
Atlanta Braves

Apr 19, 2026 - MLB

Washington Nationals
3 :  0
San Francisco Giants

Apr 18, 2026 - MLB

Washington Nationals
6 :  7
San Francisco Giants
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 24, 2026 - MLB

Chicago White Sox
5 :  4
Washington Nationals

Apr 16, 2026 - MLB

Pittsburgh Pirates
7 :  8
Washington Nationals

Apr 15, 2026 - MLB

Pittsburgh Pirates
2 :  0
Washington Nationals

Apr 14, 2026 - MLB

Pittsburgh Pirates
4 :  5
Washington Nationals

Apr 13, 2026 - MLB

Pittsburgh Pirates
16 :  5
Washington Nationals

Apr 12, 2026 - MLB

Milwaukee Brewers
6 :  8
Washington Nationals

Chicago White Sox against Washington Nationals : Head to Head (H2H)

Chicago White Sox

60 %

Washington Nationals

40 %

Apr 24, 2026 - MLB

Chicago White Sox
5 :  4
Washington Nationals

Sep 28, 2025 - MLB

Washington Nationals
0 :  8
Chicago White Sox

Sep 27, 2025 - MLB

Washington Nationals
6 :  5
Chicago White Sox

Sep 26, 2025 - MLB

Washington Nationals
9 :  10
Chicago White Sox

Sep 19, 2023 - MLB

Washington Nationals
4 :  3
Chicago White Sox

Chicago White Sox - Washington Nationals Key Points

  1. Washington leads the all-time series vs. the White Sox, 18-14.
  2. Washington last beat the White Sox in Chicago on May 14, 2024.
  3. Both teams have hit 33 home runs this season.
  4. Betting Public: 70% of moneyline tickets and 48% of the handle are on the White Sox.
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Our Chicago White Sox vs Washington Nationals Prediction

It feels strange to say it, but the White Sox have been on kind of a roll of late, with wins in four of their last five and five of their last seven. The lineup has been one of the best in baseball over the last week, hitting .289 with 16 home runs. Washington, on the other hand, has hit .218, which makes me think the run line may be the way to go. But they’ve also hit 11 home runs.  Irvin has struggled, but I don’t know how much faith I want to put in Schultz after two short starts. So, rather than go for the better-priced run line market, I’m just going for the win.

Our Washington vs. Chicago Pick: White Sox ML

Prediction:

 

White Sox ML

-140
$250 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Chicago White Sox vs Washington Nationals Picks