Chicago White Sox vs Washington Nationals Prediction & Picks - MLB

Prediction published on 4/24/26, 4:17 PM  by Lou Aguila | Modified on 4/25/26 at 2:12 PM in MLB Picks

The Over 9.5 runs may not be that high of a total in Game 1 between the Washington Nationals and the Chicago White Sox, who are both averaging at least five runs per game in their last five games.

Momentum: The Washington Nationals enter a new series with a 1-3 record in their last four games. The Nats lost 2 of 3 games in their series against the Atlanta Braves, including the finale with a score 2-7.

The Chicago White Sox have won 3 of their last 4 games, capturing a series win over the Arizona Diamondbacks after taking Game 1 (11-5) and Game 3 (4-1).

Starting Pitchers: Nationals RHP Miles Mikolas (0-3, 9.15 ERA) vs. Bryan Hudson (0-0, 1.69 ERA).

Hot on the Board: The White Sox returned home as the favorite in this game. They are listed at -125 moneyline and +158 to cover -1.5 runs. The Nationals, who are 1-4 against the White Sox, are +105 moneyline and -190 on the +1.5-run line. Total has been pegged at 9.5 runs as this series features two of the worst-pitching, but at the same time, high-scoring squads.