USC Trojans vs Notre Dame Fighting Irish Prediction & Picks - NCAA

USA - NCAA

USC Trojans
10/18/25 19:30
Notre Dame Fighting Irish

Prediction:

 

USC Trojans +10.5 Alternate Spread

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 by Matt Lowrimore in NCAA Picks

One of the most interesting games on the Saturday Week 8 college football slate will see the 20th-ranked USC Trojans take on the 13th-ranked Notre Dame Fighting Irish. Let’s take a look at the match statistics and predictions for this game between the Trojans and the Fighting Irish.

USC enters this game with a record of 5-1, having most recently beaten the Michigan Wolverines in Week 7 by a score of 31-13. The Trojans’ offense had a total of 489 yards, while its defense allowed 316 yards. Quarterback Jayden Maiava threw for 265 yards, two touchdowns, and one interception, while running back King Miller led the team in rushing with 158 yards and one touchdown.

As for Notre Dame, they enter this game with a record of 4-2, having most recently beaten the NC State Wolfpack in Week 7 by a score of 36-7. The Fighting Irish’s offense had a total of 485 yards, while its defense allowed 233 yards. Quarterback CJ Carr threw for 342 yards, two touchdowns, and one interception, while running back Jeremiyah Love led the team in rushing with 86 yards and two touchdowns.

USC Trojans vs Notre Dame Fighting Irish Form

Table

Teams % P W D L
7
USC Trojans
USC Trojans
0.75 4 3 0 1
41
Notre Dame Fighting Irish
Notre Dame Fighting Irish
0.714 7 5 0 2

USC Trojans and Notre Dame Fighting Irish Latest Matches

USC Trojans
USC Trojans Latest matches
W W W W L W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 11, 2025 - NCAA

Michigan Wolverines
13 :  31
USC Trojans

Sep 27, 2025 - NCAA

USC Trojans
32 :  34
Illinois Fighting Illini

Sep 20, 2025 - NCAA

Michigan State Spartans
31 :  45
USC Trojans

Sep 13, 2025 - NCAA

USC Trojans
33 :  17
Purdue Boilermakers

Sep 6, 2025 - NCAA

Georgia Southern Eagles
20 :  59
USC Trojans

Aug 30, 2025 - NCAA

Missouri State Bears
13 :  73
USC Trojans
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 11, 2025 - NCAA

Michigan Wolverines
13 :  31
USC Trojans

Sep 20, 2025 - NCAA

Michigan State Spartans
31 :  45
USC Trojans

Sep 6, 2025 - NCAA

Georgia Southern Eagles
20 :  59
USC Trojans

Aug 30, 2025 - NCAA

Missouri State Bears
13 :  73
USC Trojans

Dec 27, 2024 - NCAA Division I, FBS, Playoffs

Texas A&M Aggies
31 :  35
USC Trojans

Nov 30, 2024 - NCAA

Notre Dame Fighting Irish
49 :  35
USC Trojans
L L L W W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 27, 2025 - NCAA

USC Trojans
32 :  34
Illinois Fighting Illini

Sep 13, 2025 - NCAA

USC Trojans
33 :  17
Purdue Boilermakers

Nov 23, 2024 - NCAA

USC Trojans
19 :  13
UCLA Bruins

Nov 2, 2024 - NCAA

USC Trojans
21 :  26
Washington Huskies

Oct 19, 2024 - NCAA

USC Trojans
28 :  29
Maryland Terrapins

Sep 21, 2024 - NCAA

USC Trojans
24 :  27
Michigan Wolverines
Notre Dame Fighting Irish
Notre Dame Fighting Irish Latest matches
L L W W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 11, 2025 - NCAA

North Carolina State Wolfpack
7 :  36
Notre Dame Fighting Irish

Oct 4, 2025 - NCAA

Boise State Broncos
7 :  28
Notre Dame Fighting Irish

Sep 27, 2025 - NCAA

Notre Dame Fighting Irish
56 :  13
Arkansas Razorbacks

Sep 20, 2025 - NCAA

Purdue Boilermakers
30 :  56
Notre Dame Fighting Irish

Sep 13, 2025 - NCAA

Texas A&M Aggies
41 :  40
Notre Dame Fighting Irish

Aug 31, 2025 - NCAA

Notre Dame Fighting Irish
24 :  27
Miami (FL) Hurricanes
W L L W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 11, 2025 - NCAA

North Carolina State Wolfpack
7 :  36
Notre Dame Fighting Irish

Oct 4, 2025 - NCAA

Boise State Broncos
7 :  28
Notre Dame Fighting Irish

Sep 20, 2025 - NCAA

Purdue Boilermakers
30 :  56
Notre Dame Fighting Irish

Sep 13, 2025 - NCAA

Texas A&M Aggies
41 :  40
Notre Dame Fighting Irish

Jan 20, 2025 - NCAA

Ohio State Buckeyes
34 :  23
Notre Dame Fighting Irish

Dec 20, 2024 - NCAA

Indiana Hoosiers
17 :  27
Notre Dame Fighting Irish
W W W W L W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 27, 2025 - NCAA

Notre Dame Fighting Irish
56 :  13
Arkansas Razorbacks

Aug 31, 2025 - NCAA

Notre Dame Fighting Irish
24 :  27
Miami (FL) Hurricanes

Jan 9, 2025 - NCAA

Notre Dame Fighting Irish
27 :  24
Penn State Nittany Lions

Jan 2, 2025 - NCAA

Notre Dame Fighting Irish
23 :  10
Georgia Bulldogs

Nov 30, 2024 - NCAA

Notre Dame Fighting Irish
49 :  35
USC Trojans

Oct 26, 2024 - NCAA

Notre Dame Fighting Irish
51 :  14
Navy Midshipmen

USC Trojans against Notre Dame Fighting Irish : Head to Head (H2H)

Nov 30, 2024 - NCAA

Notre Dame Fighting Irish
49 :  35
USC Trojans

USC Trojans - Notre Dame Fighting Irish Key Points

  1. USC is 3-3 ATS this season
  2. USC is averaging 45.5 points per game this season
  3. Notre Dame is 3-3 ATS this season
  4. Notre Dame is averaging 40.0 points per game this season

Our USC Trojans vs Notre Dame Fighting Irish Prediction

Notre Dame is more than a touchdown favorite, which makes USC look to be the better betting option. The Fighting Irish have no doubt been dominant since their 0-2 start, but they have not faced any team since their loss to Texas A&M that stacks up to what USC brings to the table.

The Trojans are averaging 45.5 points per game this season and have the speed to be able to keep up with the Fighting Irish. Further, USC’s defense has slowly been improving, which suggests they can handle a well-balanced Fighting Irish offense.

Even though Notre Dame will be at home, these two teams look to be evenly matched; therefore, our USC Trojans vs Notre Dame Fighting Irish prediction is: USC Trojans +10.5 Alternate Spread.

Prediction:

 

USC Trojans +10.5 Alternate Spread

-131
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

USC Trojans vs Notre Dame Fighting Irish Picks