USC Trojans vs Illinois Fighting Illini Prediction & Picks - NCAA
USA - NCAA
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Matt Lowrimore | in NCAA Picks
Saturday’s Week 5 college football slate will feature a ton of interesting games, one of which will see the 21st-ranked USC Trojans take on the 23rd-ranked Illinois Fighting Illini. Let’s take a look at the match statistics and predictions for this game between the Trojans and the Fighting Illini.
USC enters this game with a record of 4-0 and 1-0 in the Big Ten. The Trojans most recently beat the Michigan State Spartans in Week 4 by a score of 45-31. USC’s offense had a total of 523 yards, while its defense allowed 337 yards. Quarterback Jayden Maiava threw for 234 yards and three touchdowns, while running back Waymond Jordan led the team in rushing with 157 yards.
As for Illinois, they enter this game with a record of 3-1 and 0-1 in the Big Ten. The Fighting Illini most recently lost to the Indiana Hoosiers in Week 4 by a score of 63-10. Illinois’ offense had a total of 161 yards, while its defense allowed 579 yards. Quarterback Luke Altmyer threw for 146 yards and one touchdown, while running back Kaden Feagin led the team in rushing with 18 yards.
Limited Offer. Currently at DraftKings
USC Trojans vs Illinois Fighting Illini Form
Table
| Teams | % | P | W | D | L |
|---|---|---|---|---|---|
|
5
|
0.778 | 9 | 7 | 0 | 2 |
|
9
|
0.556 | 9 | 5 | 0 | 4 |
USC Trojans and Illinois Fighting Illini Latest Matches
5/6 (83%)
0/6 (0%)
1/6 (17%)
Sep 20, 2025 - NCAA
Sep 13, 2025 - NCAA
Sep 6, 2025 - NCAA
Aug 30, 2025 - NCAA
Dec 27, 2024 - NCAA Division I, FBS, Playoffs
Sep 21, 2024 - NCAA
6/6 (100%)
0/6 (0%)
0/6 (0%)
Sep 20, 2025 - NCAA
Sep 6, 2025 - NCAA
Aug 30, 2025 - NCAA
Dec 27, 2024 - NCAA Division I, FBS, Playoffs
Sep 7, 2024 - NCAA
Sep 1, 2024 - NCAA
1/2 (50%)
0/2 (0%)
1/2 (50%)
Sep 13, 2025 - NCAA
Sep 21, 2024 - NCAA
4/6 (67%)
0/6 (0%)
2/6 (33%)
Sep 20, 2025 - NCAA
Sep 13, 2025 - NCAA
Sep 6, 2025 - NCAA
Aug 29, 2025 - NCAA
Dec 31, 2024 - NCAA Division I, FBS, Playoffs
Sep 28, 2024 - NCAA
5/5 (100%)
0/5 (0%)
0/5 (0%)
Sep 13, 2025 - NCAA
Aug 29, 2025 - NCAA
Dec 31, 2024 - NCAA Division I, FBS, Playoffs
Sep 7, 2024 - NCAA
Aug 29, 2024 - NCAA
2/4 (50%)
0/4 (0%)
2/4 (50%)
Sep 20, 2025 - NCAA
Sep 6, 2025 - NCAA
Sep 28, 2024 - NCAA
Sep 20, 2024 - NCAA
USC Trojans - Illinois Fighting Illini Key Points
- USC is 2-2 ATS this season
- USC is averaging 57.0 points per game this season
- Illinois is 3-1 ATS this season
- Illinois is averaging 37.8 points per game this season
Limited Offer. Currently at DraftKings
Our USC Trojans vs Illinois Fighting Illini Prediction
Illinois’ flaws were quickly taken advantage of in Week 4 by Indiana, and things will not get any easier when they play USC in Week 5. The Trojans’ offense is just as explosive as the Hoosiers, which is indicated by the fact that USC is averaging 57 points per game this season.
It is fair to say that USC’s defense is susceptible to allowing points, so Illinois should have much more success compared to the poor showing in Week 4. That being said, the Fighting Illini’s defense is likely to be overwhelmed by the speed of the Trojans’ offense. For that reason, our USC Trojans vs Illinois Fighting Illini prediction is: USC Trojans ML.All tips are fully researched and given in good faith, but profits cannot be guaranteed.