UCLA Bruins vs Indiana Hoosiers Prediction & Picks - NCAA

Prediction published on 10/25/25, 8:35 AM  by Travis Pulver in NCAA Picks

The No. 2 Indiana Hoosiers (7-0) will try to keep the good times rolling when they host the resurgent UCLA Bruins this weekend at Memorial Stadium in Bloomington, IN. Kickoff is scheduled for 12 p.m. EST, and the game will be broadcast on Fox.

This could easily turn into a trap game if Indiana is not careful. It would be easy to overlook a Bruins team that looked terrible for the first four weeks of the season. But then something clicked when they faced then-No. 7 Penn State. Nico Iamaleava finally played like the guy the Bruins thought they had poached from Tennessee, going 17-24 for 166 yards and two touchdowns while adding 128 yards and three more scores on the ground. UCLA followed that game with a dominant performance vs. Michigan State (38-13) and a win over Maryland (20-17). Of course, Indiana is in a different class than Penn State, Michigan State, and Maryland. Fernando Mendoza quarterbacks an offense that averages almost 500 yards a game, has the most efficient passing game, and averages 43.9 points per game. But while some teams excel at one side of the ball, the Hoosiers are even better on defense with a top ten run defense, the No. 15 pass defense, and the No. 4 scoring defense (11.6 ppg allowed).