Baltimore Orioles vs Toronto Blue Jays Prediction & Picks - MLB

USA - MLB

Baltimore Orioles
9/21/26 18:35
Toronto Blue Jays

Prediction:

 

Toronto ML

−107
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 by Travis Pulver | in MLB Picks

The Baltimore Orioles (75-81, 36-42 Home) will host the Toronto Blue Jays (77-79, 37-41 Away) in a three-game series this week. Game 1 of the series is scheduled for 6:35 p.m. EST today at Oriole Park at Camden Yards in Baltimore, MD, with coverage provided by ESPN Unlimited.

Baltimore will be looking to get back on the right side of the scoreboard after getting swept by the Milwaukee Brewers over the weekend. Toronto avoided getting swept by Texas with a 7-2 win over the Rangers yesterday.

Trey Yesavage is expected to come off the IL today to get the start for the Blue Jays. Yesavage has gone 5-5 this season in 18 starts with a 3.65 ERA and a 1.14 WHIP. Teams have hit .185 against him this season. He has gone 2-3 on the road in 10 starts while posting a 3.14 ERA and a .174 OBA.

As for the Orioles, Baltimore is giving Shane Baz the start. Baz has gone 6-15 in 30 starts this season with a 4.11 ERA and a 1.35 WHIP. Teams have hit .263 against him. At home, he has gone 4-7 in 15 starts with a 3.92 ERA and a .270 OBA.

                                                                                                                                              

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Baltimore Orioles vs Toronto Blue Jays Form

Table

Teams Pts P W L
17 Baltimore Orioles
0.491 161 79 82
18 Toronto Blue Jays
0.488 162 79 83

Baltimore Orioles and Toronto Blue Jays Latest Matches

Baltimore Orioles
Baltimore Orioles Latest matches
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 20, 2026 - MLB

Baltimore Orioles
0 :  3
Milwaukee Brewers

Sep 19, 2026 - MLB

Baltimore Orioles
0 :  1
Milwaukee Brewers

Sep 18, 2026 - MLB

Baltimore Orioles
5 :  6
Milwaukee Brewers

Sep 16, 2026 - MLB

New York Mets
1 :  7
Baltimore Orioles

Sep 15, 2026 - MLB

New York Mets
5 :  7
Baltimore Orioles

Sep 14, 2026 - MLB

New York Mets
1 :  2
Baltimore Orioles
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 20, 2026 - MLB

Baltimore Orioles
0 :  3
Milwaukee Brewers

Sep 19, 2026 - MLB

Baltimore Orioles
0 :  1
Milwaukee Brewers

Sep 18, 2026 - MLB

Baltimore Orioles
5 :  6
Milwaukee Brewers

Sep 9, 2026 - MLB

Baltimore Orioles
9 :  5
Cleveland Guardians

Sep 8, 2026 - MLB

Baltimore Orioles
5 :  9
Cleveland Guardians

Sep 7, 2026 - MLB

Baltimore Orioles
6 :  4
Cleveland Guardians
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 16, 2026 - MLB

New York Mets
1 :  7
Baltimore Orioles

Sep 15, 2026 - MLB

New York Mets
5 :  7
Baltimore Orioles

Sep 14, 2026 - MLB

New York Mets
1 :  2
Baltimore Orioles

Sep 13, 2026 - MLB

Toronto Blue Jays
8 :  1
Baltimore Orioles

Sep 12, 2026 - MLB

Toronto Blue Jays
7 :  3
Baltimore Orioles

Sep 11, 2026 - MLB

Toronto Blue Jays
4 :  7
Baltimore Orioles
Toronto Blue Jays
Toronto Blue Jays Latest matches
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 20, 2026 - MLB

Texas Rangers
2 :  7
Toronto Blue Jays

Sep 19, 2026 - MLB

Texas Rangers
6 :  2
Toronto Blue Jays

Sep 18, 2026 - MLB

Texas Rangers
7 :  1
Toronto Blue Jays

Sep 16, 2026 - MLB

Toronto Blue Jays
5 :  1
Detroit Tigers

Sep 15, 2026 - MLB

Toronto Blue Jays
1 :  10
Detroit Tigers

Sep 14, 2026 - MLB

Toronto Blue Jays
5 :  6
Detroit Tigers
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 16, 2026 - MLB

Toronto Blue Jays
5 :  1
Detroit Tigers

Sep 15, 2026 - MLB

Toronto Blue Jays
1 :  10
Detroit Tigers

Sep 14, 2026 - MLB

Toronto Blue Jays
5 :  6
Detroit Tigers

Sep 13, 2026 - MLB

Toronto Blue Jays
8 :  1
Baltimore Orioles

Sep 12, 2026 - MLB

Toronto Blue Jays
7 :  3
Baltimore Orioles

Sep 11, 2026 - MLB

Toronto Blue Jays
4 :  7
Baltimore Orioles
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 20, 2026 - MLB

Texas Rangers
2 :  7
Toronto Blue Jays

Sep 19, 2026 - MLB

Texas Rangers
6 :  2
Toronto Blue Jays

Sep 18, 2026 - MLB

Texas Rangers
7 :  1
Toronto Blue Jays

Sep 9, 2026 - MLB

Athletics
2 :  0
Toronto Blue Jays

Sep 8, 2026 - MLB

Athletics
2 :  4
Toronto Blue Jays

Sep 7, 2026 - MLB

Athletics
6 :  5
Toronto Blue Jays

Baltimore Orioles against Toronto Blue Jays : Head to Head (H2H)

Baltimore Orioles

33 %

Toronto Blue Jays

67 %

Sep 13, 2026 - MLB

Toronto Blue Jays
8 :  1
Baltimore Orioles

Sep 12, 2026 - MLB

Toronto Blue Jays
7 :  3
Baltimore Orioles

Sep 11, 2026 - MLB

Toronto Blue Jays
4 :  7
Baltimore Orioles

Jun 7, 2026 - MLB

Toronto Blue Jays
6 :  4
Baltimore Orioles

Jun 6, 2026 - MLB

Toronto Blue Jays
6 :  4
Baltimore Orioles

Jun 5, 2026 - MLB

Toronto Blue Jays
3 :  13
Baltimore Orioles
Baltimore Orioles vs Toronto Blue Jays Picks

Baltimore Orioles - Toronto Blue Jays Key Points

  1. Toronto has gone 19-17 against Baltimore over the last three seasons and leads the season series, 6-4.
  2. Baltimore is 41-37 ATS (run line) at home this season; Toronto is 37-41 ATS (run line) on the road.
  3. The OVER is 35-40-3 for the Orioles at home and 41-35-2 for Toronto on the road.
  4. Betting Public: 57% of moneyline tickets and 66% of the handle are on the Blue Jays.

Our Baltimore Orioles vs Toronto Blue Jays Prediction

Neither team has been hitting well over the last week (Toronto: .228 BA; Baltimore: .219 BA), and both generated 21 runs. So, no one has a real advantage at the plate for this game. On the mound, however, the Blue Jays absolutely have an edge. Yesavage has been the better pitcher between the two all season, but he went 0-1 in two starts vs. the Orioles this season. Baz has had a rough year and took the loss in his first start vs. Toronto (June 7).

However, with neither team hitting well and Yesavage not being too consistent this season, I would not recommend the run line.

Our Toronto vs. Baltimore Pick: Toronto ML

Prediction:

 

Toronto ML

−107
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.