Tampa Bay Buccaneers vs Seattle Seahawks Prediction & Picks - NFL

USA - NFL

Tampa Bay Buccaneers
10/5/25 16:05
Seattle Seahawks

Prediction:

 

Over 45.5

-106
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 by Erik Gibbs in NFL Picks

The Tampa Bay Buccaneers and Seattle Seahawks meet Sunday at Lumen Field in a pivotal NFC showdown between two first-place teams. Both enter the week at 3-1, making this one of the most important early-season matchups in the conference. Tampa Bay is coming off a 31-25 loss to the Philadelphia Eagles, a game where their offense disappeared in the second half. The Buccaneers still hold first place in the NFC South, but they’ll face major challenges on offense this week. With Irving and Evans both ruled out, quarterback Baker Mayfield will be forced to shoulder more of the workload against one of the league’s best defensive units.

Seattle enters this game riding the momentum of a 23-20 win over Arizona. The Seahawks currently lead the NFC West and have been one of the most balanced teams in the league so far. Offensively, they rank sixth in scoring at 27.8 points per game, and defensively, they’re second in the NFL, giving up just 16.8 points per contest. That balance has been the key to their early success, with the team showing an ability to both control the clock and limit explosive plays.

Tampa Bay Buccaneers vs Seattle Seahawks Form

Table

Teams % P W D L
5
Seattle Seahawks
Seattle Seahawks
0.75 4 3 0 1
10
Tampa Bay Buccaneers
Tampa Bay Buccaneers
0.75 4 3 0 1

Tampa Bay Buccaneers and Seattle Seahawks Latest Matches

Tampa Bay Buccaneers
Tampa Bay Buccaneers Latest matches
W L W W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 28, 2025 - NFL

Philadelphia Eagles
31 :  25
Tampa Bay Buccaneers

Sep 21, 2025 - NFL

New York Jets
27 :  29
Tampa Bay Buccaneers

Sep 15, 2025 - NFL

Tampa Bay Buccaneers
20 :  19
Houston Texans

Sep 7, 2025 - NFL

Tampa Bay Buccaneers
23 :  20
Atlanta Falcons

Jan 12, 2025 - NFL

Washington Commanders
23 :  20
Tampa Bay Buccaneers

Jan 5, 2025 - NFL

New Orleans Saints
19 :  27
Tampa Bay Buccaneers
W W W L W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 28, 2025 - NFL

Philadelphia Eagles
31 :  25
Tampa Bay Buccaneers

Sep 21, 2025 - NFL

New York Jets
27 :  29
Tampa Bay Buccaneers

Jan 12, 2025 - NFL

Washington Commanders
23 :  20
Tampa Bay Buccaneers

Jan 5, 2025 - NFL

New Orleans Saints
19 :  27
Tampa Bay Buccaneers

Dec 29, 2024 - NFL

Carolina Panthers
14 :  48
Tampa Bay Buccaneers

Dec 8, 2024 - NFL

Las Vegas Raiders
13 :  28
Tampa Bay Buccaneers
W W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 15, 2025 - NFL

Tampa Bay Buccaneers
20 :  19
Houston Texans

Sep 7, 2025 - NFL

Tampa Bay Buccaneers
23 :  20
Atlanta Falcons

Dec 22, 2024 - NFL

Tampa Bay Buccaneers
24 :  26
Dallas Cowboys

Dec 15, 2024 - NFL

Tampa Bay Buccaneers
40 :  17
Los Angeles Chargers

Dec 1, 2024 - NFL

Tampa Bay Buccaneers
26 :  23
Carolina Panthers

Nov 24, 2024 - NFL

Tampa Bay Buccaneers
30 :  7
New York Giants
Seattle Seahawks
Seattle Seahawks Latest matches
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 25, 2025 - NFL

Seattle Seahawks
23 :  20
Arizona Cardinals

Sep 21, 2025 - NFL

New Orleans Saints
13 :  44
Seattle Seahawks

Sep 14, 2025 - NFL

Seattle Seahawks
31 :  17
Pittsburgh Steelers

Sep 7, 2025 - NFL

San Francisco 49ers
17 :  13
Seattle Seahawks

Jan 5, 2025 - NFL

Seattle Seahawks
30 :  25
Los Angeles Rams

Dec 26, 2024 - NFL

Seattle Seahawks
6 :  3
Chicago Bears
L W L L L W
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 21, 2025 - NFL

New Orleans Saints
13 :  44
Seattle Seahawks

Sep 7, 2025 - NFL

San Francisco 49ers
17 :  13
Seattle Seahawks

Dec 22, 2024 - NFL

Minnesota Vikings
27 :  24
Seattle Seahawks

Dec 15, 2024 - NFL

Green Bay Packers
30 :  13
Seattle Seahawks

Nov 24, 2024 - NFL

Arizona Cardinals
6 :  16
Seattle Seahawks

Nov 3, 2024 - NFL

Los Angeles Rams
26 :  20
Seattle Seahawks
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Sep 25, 2025 - NFL

Seattle Seahawks
23 :  20
Arizona Cardinals

Sep 14, 2025 - NFL

Seattle Seahawks
31 :  17
Pittsburgh Steelers

Jan 5, 2025 - NFL

Seattle Seahawks
30 :  25
Los Angeles Rams

Dec 26, 2024 - NFL

Seattle Seahawks
6 :  3
Chicago Bears

Dec 8, 2024 - NFL

Seattle Seahawks
30 :  18
Arizona Cardinals

Dec 1, 2024 - NFL

Seattle Seahawks
26 :  21
New York Jets

Tampa Bay Buccaneers against Seattle Seahawks : Head to Head (H2H)

Nov 3, 2019 - NFL

Tampa Bay Buccaneers
34 :  40
Seattle Seahawks

Tampa Bay Buccaneers - Seattle Seahawks Key Points

  1. The Over is 11-1 in the Seahawks’ last 12 home games vs. NFC South teams
  2. The Over is 1-9 in the Buccaneers’ last 10 road games after a home loss
  3. The Buccaneers are 1-10 in their last 11 games vs. teams on a winning streak
  4. The Buccaneers are 0-4 ATS in their last 4 Week 5 games vs. NFC teams

Our Tampa Bay Buccaneers vs Seattle Seahawks Prediction

This matchup will likely hinge on whether Tampa Bay can find rhythm through the air. Mayfield will need to rely on quick passes and his secondary receivers to keep drives alive, as Seattle’s front seven has been tough on both the run and intermediate passing lanes. The Buccaneers’ defense has been inconsistent, and if they can’t generate pressure or tighten coverage, Seattle should be able to move the ball effectively.

Historically, Tampa Bay has had some success in this series, winning five of the last seven meetings, including a 21-16 victory in 2022. However, the Seahawks have dominated at home, going 3-1 in their last four in Seattle and outscoring opponents by an average of 11 points per game this season. With home-field advantage, better health, and stronger overall balance, Seattle is the clear favorite to take control early and stay ahead. Our prediction for Seattle Seahawks vs. Tampa Bay Buccaneers: Over 45.5 points.

Prediction:

 

Over 45.5

-106
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Tampa Bay Buccaneers vs Seattle Seahawks Picks