Tampa Bay Rays vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

Tampa Bay Rays
8/21/25 19:35
St. Louis Cardinals

Prediction:

 

Cardinals will cover -1.5 Runs

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 by Lou Aguila | in MLB Picks

The St. Louis Cardinals will attempt to keep their winning form going, as they target their third win in four games in Thursday’s series opener against the Tampa Bay Rays at George Steinbrenner Field.

The Cardinals took 2 out of 3 games in their previous series with the Miami Marlins. Although they could not complete a sweep after dropping Game 3, 2-6, St. Louis still bumped up their regular-season record to 63-65, fourth in the NL Central. St. Louis will still be missing the service of second baseman Brendan Donovan, who was placed on the injured list Monday with a left groin strain.

Meanwhile, the Rays are coming into the new series with deflated confidence after absorbing back-to-back losses in their two-game series with the New York Yankees. Tampa Bay lost Game 1 in a blowout, 3-13, before losing Game 2, 4-6, in extra innings after letting Giancarlo Stanton and Austin Wells homer in the 10th inning.

Tampa Bay Rays vs St. Louis Cardinals Form

Table

Teams Pts P W L
20 St. Louis Cardinals
0.481 162 78 84
21 Tampa Bay Rays
0.475 162 77 85

Tampa Bay Rays and St. Louis Cardinals Latest Matches

Tampa Bay Rays
Tampa Bay Rays Latest matches
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 20, 2025 - MLB

Tampa Bay Rays
4 :  6
New York Yankees

Aug 19, 2025 - MLB

Tampa Bay Rays
3 :  13
New York Yankees

Aug 17, 2025 - MLB

San Francisco Giants
7 :  1
Tampa Bay Rays

Aug 16, 2025 - MLB

San Francisco Giants
1 :  2
Tampa Bay Rays

Aug 15, 2025 - MLB

San Francisco Giants
6 :  7
Tampa Bay Rays

Aug 13, 2025 - MLB

Athletics
2 :  8
Tampa Bay Rays
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 20, 2025 - MLB

Tampa Bay Rays
4 :  6
New York Yankees

Aug 19, 2025 - MLB

Tampa Bay Rays
3 :  13
New York Yankees

Aug 3, 2025 - MLB

Tampa Bay Rays
0 :  3
Los Angeles Dodgers

Aug 2, 2025 - MLB

Tampa Bay Rays
4 :  0
Los Angeles Dodgers

Aug 1, 2025 - MLB

Tampa Bay Rays
0 :  5
Los Angeles Dodgers

Jul 23, 2025 - MLB

Tampa Bay Rays
9 :  11
Chicago White Sox
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 17, 2025 - MLB

San Francisco Giants
7 :  1
Tampa Bay Rays

Aug 16, 2025 - MLB

San Francisco Giants
1 :  2
Tampa Bay Rays

Aug 15, 2025 - MLB

San Francisco Giants
6 :  7
Tampa Bay Rays

Aug 13, 2025 - MLB

Athletics
2 :  8
Tampa Bay Rays

Aug 12, 2025 - MLB

Athletics
6 :  0
Tampa Bay Rays

Aug 11, 2025 - MLB

Athletics
4 :  7
Tampa Bay Rays
St. Louis Cardinals
St. Louis Cardinals Latest matches
L L L W W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 20, 2025 - MLB

Miami Marlins
6 :  2
St. Louis Cardinals

Aug 19, 2025 - MLB

Miami Marlins
4 :  7
St. Louis Cardinals

Aug 18, 2025 - MLB

Miami Marlins
3 :  8
St. Louis Cardinals

Aug 17, 2025 - MLB

St. Louis Cardinals
4 :  8
New York Yankees

Aug 16, 2025 - MLB

St. Louis Cardinals
8 :  12
New York Yankees

Aug 15, 2025 - MLB

St. Louis Cardinals
3 :  4
New York Yankees
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 17, 2025 - MLB

St. Louis Cardinals
4 :  8
New York Yankees

Aug 16, 2025 - MLB

St. Louis Cardinals
8 :  12
New York Yankees

Aug 15, 2025 - MLB

St. Louis Cardinals
3 :  4
New York Yankees

Aug 13, 2025 - MLB

St. Louis Cardinals
5 :  6
Colorado Rockies

Aug 12, 2025 - MLB

St. Louis Cardinals
0 :  3
Colorado Rockies

Aug 11, 2025 - MLB

St. Louis Cardinals
3 :  2
Colorado Rockies
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 20, 2025 - MLB

Miami Marlins
6 :  2
St. Louis Cardinals

Aug 19, 2025 - MLB

Miami Marlins
4 :  7
St. Louis Cardinals

Aug 18, 2025 - MLB

Miami Marlins
3 :  8
St. Louis Cardinals

Aug 6, 2025 - MLB

Los Angeles Dodgers
3 :  5
St. Louis Cardinals

Aug 5, 2025 - MLB

Los Angeles Dodgers
12 :  6
St. Louis Cardinals

Aug 4, 2025 - MLB

Los Angeles Dodgers
2 :  3
St. Louis Cardinals

Tampa Bay Rays against St. Louis Cardinals : Head to Head (H2H)

Tampa Bay Rays

100 %

St. Louis Cardinals

0 %

Aug 8, 2023 - MLB

Tampa Bay Rays
4 :  2
St. Louis Cardinals

Tampa Bay Rays - St. Louis Cardinals Key Points

  1. St. Louis is 4-1 SU in its last 5 games against Tampa Bay.
  2. St. Louis is 4-2 SU in its last 6 games on the road.
  3. Tampa Bay is 7-13 SU in its last 20 games.
  4. Tampa Bay is 1-5 SU in its last 6 games at home.

Our Tampa Bay Rays vs St. Louis Cardinals Prediction

Pick the Cardinals -1.5 Runs.

The Cardinals are 4-1 in their last five games against the Rays and 4-2 on the road. They may never go beyond September this year, but St. Louis has shown characteristics of a future playoff team in the coming years. In their last three meetings against the Rays, they have held Tampa Bay to an average of 3.67 runs while scoring 4.33 runs per game.

The Cards have tapped starting pitcher Sonny Grey, who squandered six earned runs over five innings in his last start vs. the Yankees, but averages only 2.3 earned runs over his last three starts against the Rays. Tampa Bay, meanwhile, will dispatch right-handed pitcher Joe Boyle. Boyle, who has allowed a total of 10 runs over his last two starts, will be pitching against the Cardinals for the first time in his career. St. Louis could take advantage of a still unseasoned Boyle as they try to take the early lead. The Rays starters have given up a 6.65 ERA over the last five games. Furthermore, Tampa Bay is only averaging 3.3 runs per game over this stretch, which could put them at a disadvantage against a team that is scoring almost six runs a game (5.8 runs per game) in their last five games.

Our betting prediction for the Tampa Bay Rays vs. St. Louis Cardinals: The Cardinals -1.5 Runs.

Prediction:

 

Cardinals will cover -1.5 Runs

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Tampa Bay Rays vs St. Louis Cardinals Picks