San Francisco Giants vs St. Louis Cardinals Prediction & Picks - MLB
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by Carlos Zabala in MLB Picks
The series between the Cardinals and Giants in San Francisco had a back-and-forth first game, but the Giants ultimately won it 5-4 via walk-off on a Shay Whitcomb RBI single in the 11th inning.
While the Cardinals are dealing with injuries and fighting to maintain any hope of a wild card, the Giants are already looking ahead to 2026 but are enjoying a period of high production from Devers' bat. The Dominican once again managed to put up impressive numbers; he became the first Giants player since 2002 to reach 35 home runs and 35 doubles in a single season.
The Giants took Game 2 again, led by a solid performance from Roupp, who pitched six innings and struck out two. The Giants had a chance to extend their lead in the bottom of the seventh, with the bases loaded and no outs, but failed to add any runs. The Cardinals loaded the bases in the top of the eighth but were unable to overcome the deficit.
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San Francisco Giants vs St. Louis Cardinals Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
17
|
0.493 | 146 | 72 | 74 |
|
27
|
0.418 | 146 | 61 | 85 |
San Francisco Giants and St. Louis Cardinals Latest Matches
3/6 (50%)
3/6 (50%)
Sep 7, 2026 - MLB
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2/6 (33%)
4/6 (67%)
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3/6 (50%)
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2/6 (33%)
4/6 (67%)
Aug 30, 2026 - MLB
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3/6 (50%)
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San Francisco Giants against St. Louis Cardinals : Head to Head (H2H)
33 %
67 %
Sep 7, 2026 - MLB
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San Francisco Giants - St. Louis Cardinals Key Points
- The Cardinals' O/U record this season is 66-73
- The Giants' home record this season is 34-36
- The Cardinals' road record this season is 38-36
- Schmitt and Adames are among the Giants' injured players
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Our San Francisco Giants vs St. Louis Cardinals Prediction
This is a series where the Cardinals have missed the clutch bat of JJ Wetherholt, who is out with a wrist injury. As many as 19 Cardinals players left bases in Tuesday's game.
The series finale will feature Andre Pallante pitching for the Cardinals; he has a 12-6 record, a 3.51 ERA, and a 1.24 WHIP. Blade Tidwell will start for the Giants, a 25-year-old pitcher with a 4.43 ERA and a 1.24 WHIP this season.
Our prediction for Giants vs Cardinals is: Under 8.5 runs.
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