Pittsburgh Pirates vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

Pittsburgh Pirates
9/24/26 12:35
St. Louis Cardinals

Prediction:

 

Cardinals to win

+135
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 by Simon Day | in MLB Picks

The Pittsburgh Pirates' five game winning streak came to an abrupt end on Wednesday, as they were comfortably beaten 5-1 by NL Central rivals the St Louis Cardinals. 

The sides meet for the final time this season on Thursday afternoon, and whilst both are out of playoff contention, it should still be an exciting contest between two evenly matched squads.

Whilst the Cardinals are currently standing at .487 for the season, they have shown plenty of promising signs in recent weeks, so they will be confident of finishing the campaign on a high. 

The same could be said for the Pirates, as prior to Wednesday's surprise loss, they had been playing their best ball of the season. Their five game winning streak had been full of clutch plays from their star players, and whilst that excellent run came too late for a playoff push this season, it does bode very well for the 2027 campaign. 

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Pittsburgh Pirates vs St. Louis Cardinals Form

Table

Teams Pts P W L
13 Pittsburgh Pirates
0.506 162 82 80
19 St. Louis Cardinals
0.475 162 77 85

Pittsburgh Pirates and St. Louis Cardinals Latest Matches

Pittsburgh Pirates
Pittsburgh Pirates Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 23, 2026 - MLB

Pittsburgh Pirates
1 :  5
St. Louis Cardinals

Sep 22, 2026 - MLB

Pittsburgh Pirates
2 :  0
St. Louis Cardinals

Sep 20, 2026 - MLB

Pittsburgh Pirates
4 :  3
Kansas City Royals

Sep 19, 2026 - MLB

Pittsburgh Pirates
6 :  5
Kansas City Royals

Sep 18, 2026 - MLB

Pittsburgh Pirates
8 :  5
Kansas City Royals

Sep 17, 2026 - MLB

Pittsburgh Pirates
7 :  4
Milwaukee Brewers
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 23, 2026 - MLB

Pittsburgh Pirates
1 :  5
St. Louis Cardinals

Sep 22, 2026 - MLB

Pittsburgh Pirates
2 :  0
St. Louis Cardinals

Sep 20, 2026 - MLB

Pittsburgh Pirates
4 :  3
Kansas City Royals

Sep 19, 2026 - MLB

Pittsburgh Pirates
6 :  5
Kansas City Royals

Sep 18, 2026 - MLB

Pittsburgh Pirates
8 :  5
Kansas City Royals

Sep 17, 2026 - MLB

Pittsburgh Pirates
7 :  4
Milwaukee Brewers
W W W L L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 13, 2026 - MLB

Chicago Cubs
3 :  4
Pittsburgh Pirates

Sep 12, 2026 - MLB

Chicago Cubs
4 :  3
Pittsburgh Pirates

Sep 11, 2026 - MLB

Chicago Cubs
12 :  2
Pittsburgh Pirates

Sep 10, 2026 - MLB

Chicago White Sox
0 :  2
Pittsburgh Pirates

Sep 9, 2026 - MLB

Chicago White Sox
2 :  4
Pittsburgh Pirates

Sep 8, 2026 - MLB

Chicago White Sox
3 :  9
Pittsburgh Pirates
St. Louis Cardinals
St. Louis Cardinals Latest matches
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 23, 2026 - MLB

Pittsburgh Pirates
1 :  5
St. Louis Cardinals

Sep 22, 2026 - MLB

Pittsburgh Pirates
2 :  0
St. Louis Cardinals

Sep 20, 2026 - MLB

St. Louis Cardinals
5 :  3
Washington Nationals

Sep 19, 2026 - MLB

St. Louis Cardinals
5 :  8
Washington Nationals

Sep 18, 2026 - MLB

St. Louis Cardinals
1 :  9
Washington Nationals

Sep 16, 2026 - MLB

St. Louis Cardinals
5 :  6
San Francisco Giants
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 20, 2026 - MLB

St. Louis Cardinals
5 :  3
Washington Nationals

Sep 19, 2026 - MLB

St. Louis Cardinals
5 :  8
Washington Nationals

Sep 18, 2026 - MLB

St. Louis Cardinals
1 :  9
Washington Nationals

Sep 16, 2026 - MLB

St. Louis Cardinals
5 :  6
San Francisco Giants

Sep 15, 2026 - MLB

St. Louis Cardinals
3 :  10
San Francisco Giants

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 23, 2026 - MLB

Pittsburgh Pirates
1 :  5
St. Louis Cardinals

Sep 22, 2026 - MLB

Pittsburgh Pirates
2 :  0
St. Louis Cardinals

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals

Sep 7, 2026 - MLB

San Francisco Giants
5 :  4
St. Louis Cardinals

Sep 6, 2026 - MLB

Colorado Rockies
8 :  10
St. Louis Cardinals

Pittsburgh Pirates against St. Louis Cardinals : Head to Head (H2H)

Pittsburgh Pirates

67 %

St. Louis Cardinals

33 %

Sep 23, 2026 - MLB

Pittsburgh Pirates
1 :  5
St. Louis Cardinals

Sep 22, 2026 - MLB

Pittsburgh Pirates
2 :  0
St. Louis Cardinals

Aug 30, 2026 - MLB

St. Louis Cardinals
4 :  5
Pittsburgh Pirates

Aug 29, 2026 - MLB

St. Louis Cardinals
2 :  6
Pittsburgh Pirates

Aug 28, 2026 - MLB

St. Louis Cardinals
4 :  1
Pittsburgh Pirates

May 21, 2026 - MLB

St. Louis Cardinals
2 :  6
Pittsburgh Pirates
Pittsburgh Pirates vs St. Louis Cardinals Picks

Pittsburgh Pirates - St. Louis Cardinals Key Points

  1. Cardinals starting pitcher Kyle Leahy is 10-5 for the season
  2. The Cardinals are 39-38 on the road this season
  3. St Louis have won 6 of their last 7 in Pittsburgh
  4. St Louis have scored 31 runs in their last 5 games at Pittsburgh
Up to $250 to bet on Pittsburgh Pirates - St. Louis Cardinals! 

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Our Pittsburgh Pirates vs St. Louis Cardinals Prediction

The Pirates are reasonably strong favorites here, but we think the Cards have the all-important edge on the mound.

Paul Skenes has been inconsistent for the Pirates, and his 3.91 ERA for the season is a poor stat for such a highly talented pitcher. 

In contrast, Kyle Leahy is enjoying a solid season for St. Louis. And while his pitch count may be limited on Thursday, we still think he will do enough to limit the Pittsburgh offense and help the Cards pick up a series victory. 

Our prediction for Pittsburgh Pirates vs St Louis Cardinals is: Cardinals to win. 

Prediction:

 

Cardinals to win

+135
$250 offered for betting!

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