Pittsburgh Pirates vs St. Louis Cardinals Prediction & Picks - MLB
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by Stephen Abiola | in MLB Picks
Pittsburgh Pirates (79-77) will open their final home series this season when they host St. Louis Cardinals (76-80) on Tuesday night. The Pirates were officially eliminated from the 2026 playoff race following San Diego’s 8-2 win over Miami Marlins. They did everything they could to stay in the race, including a three-game series sweep over the Royals in their most recent assignment. Still, they’ll want to win their remaining home series. The Pirates are the -160 favorites tonight.
St. Louis Cardinals, on the other hand, are the +120 betting underdogs tonight. They’ve been bitten by the injury bug several times this season, leaving them short of squad depth. The Cardinals will be searching for their first series win after dropping their last two assignments. In their latest outing, they were defeated 2-1 by the Nationals at home, giving up 20 runs in the process. Their pitching staff has been underwhelming in recent games.
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Pittsburgh Pirates vs St. Louis Cardinals Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
13
|
0.506 | 162 | 82 | 80 |
|
19
|
0.475 | 162 | 77 | 85 |
Pittsburgh Pirates and St. Louis Cardinals Latest Matches
4/6 (67%)
2/6 (33%)
Sep 20, 2026 - MLB
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4/6 (67%)
2/6 (33%)
Sep 20, 2026 - MLB
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4/6 (67%)
2/6 (33%)
Sep 13, 2026 - MLB
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2/6 (33%)
4/6 (67%)
Sep 20, 2026 - MLB
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Sep 14, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 20, 2026 - MLB
Sep 19, 2026 - MLB
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Sep 14, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 9, 2026 - MLB
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Sep 4, 2026 - MLB
Pittsburgh Pirates against St. Louis Cardinals : Head to Head (H2H)
67 %
33 %
Aug 30, 2026 - MLB
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Pittsburgh Pirates - St. Louis Cardinals Key Points
- The total runs went over 6.5 in eight of the last nine Pittsburgh Pirates matches.
- The total runs went over 6.5 in five of the last six Pittsburgh Pirates home games.
- The Pirates won their last four home matches.
- The Pirates won their last four matches all-time.
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Our Pittsburgh Pirates vs St. Louis Cardinals Prediction
The Pirates have been scoring runs in their recent games, making them an exciting moneyline choice. They’ve racked up 30 runs in their last six matches, translating into five runs per game. The numbers are even more impressive at home, where they’ve scored 25 runs in their last four assignments. This attacking efficiency could cause problems for the struggling Cardinals. St. Louis will try to limit the damage by starting Andre Pallente, who is 12-7 this season with a 3.70 ERA. He’s capable of controlling the early innings, although the Pirates can mount a late push to grab the win. The Pirates will start Jared Jones, who has a 4-6 record this year with a 4.17 ERA. The over 6.5 line seems like a reasonable choice here.
Our prediction for Pittsburgh Pirates vs St. Louis Cardinals: Pittsburgh Pirates to win.
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