Pittsburgh Pirates vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

Pittsburgh Pirates
4/28/26 18:40
St. Louis Cardinals

Prediction:

 

Pittsburgh Pirates to win.

-160
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 by Stephen Abiola | in MLB Picks

Pittsburgh Pirates and St. Louis Cardinals will clash in the second match of this four-game series on Tuesday night at PNC Park. The Pirates will be looking for an immediate response after opening this series with a 2-4 defeat on Monday night. It was a disappointing night for the hosts, who led for much of the night with Nick Gonzalez getting three hits. They’ve looked composed at home this season, and will be keen to respond early in this series.

The Cardinals, meanwhile, caused an upset on Monday after getting their surprise victory. This win marked an end to their four-game losing run, including a three-game series loss to the Mariners last week. Despite scoring 4 runs yesterday night, their offense was uninspiring until the eighth inning when they exploded to life. It’s difficult to gauge their improvement based on this result.

Pittsburgh Pirates vs St. Louis Cardinals Form

Table

Teams Pts P W L
11 St. Louis Cardinals
0.525 80 42 38
16 Pittsburgh Pirates
0.494 83 41 42

Pittsburgh Pirates and St. Louis Cardinals Latest Matches

Pittsburgh Pirates
Pittsburgh Pirates Latest matches
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 27, 2026 - MLB

Pittsburgh Pirates
2 :  4
St. Louis Cardinals

Apr 26, 2026 - MLB

Milwaukee Brewers
5 :  0
Pittsburgh Pirates

Apr 25, 2026 - MLB

Milwaukee Brewers
3 :  6
Pittsburgh Pirates

Apr 24, 2026 - MLB

Milwaukee Brewers
0 :  6
Pittsburgh Pirates

Apr 23, 2026 - MLB

Texas Rangers
6 :  1
Pittsburgh Pirates

Apr 22, 2026 - MLB

Texas Rangers
4 :  8
Pittsburgh Pirates
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 27, 2026 - MLB

Pittsburgh Pirates
2 :  4
St. Louis Cardinals

Apr 19, 2026 - MLB

Pittsburgh Pirates
6 :  3
Tampa Bay Rays

Apr 18, 2026 - MLB

Pittsburgh Pirates
7 :  8
Tampa Bay Rays

Apr 17, 2026 - MLB

Pittsburgh Pirates
5 :  1
Tampa Bay Rays

Apr 16, 2026 - MLB

Pittsburgh Pirates
7 :  8
Washington Nationals

Apr 15, 2026 - MLB

Pittsburgh Pirates
2 :  0
Washington Nationals
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 26, 2026 - MLB

Milwaukee Brewers
5 :  0
Pittsburgh Pirates

Apr 25, 2026 - MLB

Milwaukee Brewers
3 :  6
Pittsburgh Pirates

Apr 24, 2026 - MLB

Milwaukee Brewers
0 :  6
Pittsburgh Pirates

Apr 23, 2026 - MLB

Texas Rangers
6 :  1
Pittsburgh Pirates

Apr 22, 2026 - MLB

Texas Rangers
4 :  8
Pittsburgh Pirates

Apr 21, 2026 - MLB

Texas Rangers
5 :  1
Pittsburgh Pirates
St. Louis Cardinals
St. Louis Cardinals Latest matches
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 27, 2026 - MLB

Pittsburgh Pirates
2 :  4
St. Louis Cardinals

Apr 26, 2026 - MLB

St. Louis Cardinals
2 :  3
Seattle Mariners

Apr 25, 2026 - MLB

St. Louis Cardinals
9 :  11
Seattle Mariners

Apr 24, 2026 - MLB

St. Louis Cardinals
2 :  3
Seattle Mariners

Apr 22, 2026 - MLB

Miami Marlins
4 :  1
St. Louis Cardinals

Apr 21, 2026 - MLB

Miami Marlins
3 :  5
St. Louis Cardinals
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 26, 2026 - MLB

St. Louis Cardinals
2 :  3
Seattle Mariners

Apr 25, 2026 - MLB

St. Louis Cardinals
9 :  11
Seattle Mariners

Apr 24, 2026 - MLB

St. Louis Cardinals
2 :  3
Seattle Mariners

Apr 15, 2026 - MLB

St. Louis Cardinals
5 :  3
Cleveland Guardians

Apr 14, 2026 - MLB

St. Louis Cardinals
6 :  5
Cleveland Guardians

Apr 13, 2026 - MLB

St. Louis Cardinals
3 :  9
Cleveland Guardians
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 27, 2026 - MLB

Pittsburgh Pirates
2 :  4
St. Louis Cardinals

Apr 22, 2026 - MLB

Miami Marlins
4 :  1
St. Louis Cardinals

Apr 21, 2026 - MLB

Miami Marlins
3 :  5
St. Louis Cardinals

Apr 20, 2026 - MLB

Miami Marlins
5 :  3
St. Louis Cardinals

Apr 19, 2026 - MLB

Houston Astros
5 :  7
St. Louis Cardinals

Apr 18, 2026 - MLB

Houston Astros
5 :  7
St. Louis Cardinals

Pittsburgh Pirates against St. Louis Cardinals : Head to Head (H2H)

Pittsburgh Pirates

50 %

St. Louis Cardinals

50 %

Apr 27, 2026 - MLB

Pittsburgh Pirates
2 :  4
St. Louis Cardinals

Mar 5, 2026 - MLB Spring Training

Pittsburgh Pirates
2 :  3
St. Louis Cardinals

Mar 1, 2026 - MLB Spring Training

St. Louis Cardinals
1 :  6
Pittsburgh Pirates

Aug 28, 2025 - MLB

St. Louis Cardinals
4 :  1
Pittsburgh Pirates

Aug 27, 2025 - MLB

St. Louis Cardinals
1 :  2
Pittsburgh Pirates

Aug 26, 2025 - MLB

St. Louis Cardinals
3 :  8
Pittsburgh Pirates

Pittsburgh Pirates - St. Louis Cardinals Key Points

  1. The Cardinals are 1-4 in their last five matches all-time.
  2. The Pirates are 8-6 at home this season.
  3. The Pirates are 11-5 as betting favorites this season
  4. The total runs went under in six of the last seven St. Louis matches.

Our Pittsburgh Pirates vs St. Louis Cardinals Prediction

The Pirates are the -165 betting favorites. They’ll come into this contest with superior batting and pitching statistics. They boast a solid batting average of .241, which is slightly higher than the Cardinals’ .234. In the pitching department, the Pirates are fourth in baseball with a respectable ERA of 3.36, while the Cardinals are 27th with an average of 4.77. The starting pitchers also suggest we should expect a close game. The Pirates will start Bubba Chandler (1-2, 4.88 ERA), whereas the Cardinals will play Andre Pallante (2-2, 4.26 ERA). We don’t think Andre’s statistics automatically translate into an advantage against the Pirates on the road. It should be another close contest with the total runs staying under 8.5.

Our prediction for Pittsburgh Pirates vs St. Louis Cardinals: Pittsburgh Pirates to win.

Prediction:

 

Pittsburgh Pirates to win.

-160
$350 offered for betting!

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Pittsburgh Pirates vs St. Louis Cardinals Picks