Pittsburgh Pirates vs St. Louis Cardinals Prediction & Picks - MLB
USA - MLB
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Travis Pulver | in MLB Picks
The Pittsburgh Pirates (16-12, 8-5 Home) will get the week started with a three-game series vs. one of their division rivals, the St. Louis Cardinals (14-13, 7-5 Away). Fans can follow the action at PNC Park in Pittsburgh, PA, on MLB.TV once the game gets underway at 6:40 p.m. EST.
Pittsburgh is coming off a loss to the Milwaukee Brewers on Sunday, getting shut out after scoring six runs in wins on Saturday and Friday. As for the Cardinals, the struggle has been real as they’ve lost four in a row and failed to score more than two runs in three of those games.
St. Louis will hope Dustin May can help get them back on track with a solid day on the mound. May is 3-2 in five starts with a 5.84 ERA and a 1.54 WHIP. But his overall stats do not reflect on how he has pitched his last few games. After giving up 13 runs in his first two starts, he has allowed just four over his last three starts (one in each of his last two).
As for Pittsburgh, the Pirates appear to be going with a bullpen day, with reliever Mason Montgomery set to start the day on the mound. Montgomery has appeared in 12 games so far this season and pitched more than one inning in just a single game. But he has not given up a run in his last seven appearances.
Limited Offer. Currently at DraftKings
Pittsburgh Pirates vs St. Louis Cardinals Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
11
|
0.525 | 80 | 42 | 38 |
|
16
|
0.494 | 83 | 41 | 42 |
Pittsburgh Pirates and St. Louis Cardinals Latest Matches
3/6 (50%)
3/6 (50%)
Apr 26, 2026 - MLB
Apr 25, 2026 - MLB
Apr 24, 2026 - MLB
Apr 23, 2026 - MLB
Apr 22, 2026 - MLB
Apr 21, 2026 - MLB
3/6 (50%)
3/6 (50%)
Apr 19, 2026 - MLB
Apr 18, 2026 - MLB
Apr 17, 2026 - MLB
Apr 16, 2026 - MLB
Apr 15, 2026 - MLB
Apr 14, 2026 - MLB
3/6 (50%)
3/6 (50%)
Apr 26, 2026 - MLB
Apr 25, 2026 - MLB
Apr 24, 2026 - MLB
Apr 23, 2026 - MLB
Apr 22, 2026 - MLB
Apr 21, 2026 - MLB
1/6 (17%)
5/6 (83%)
Apr 26, 2026 - MLB
Apr 25, 2026 - MLB
Apr 24, 2026 - MLB
Apr 22, 2026 - MLB
Apr 21, 2026 - MLB
Apr 20, 2026 - MLB
2/6 (33%)
4/6 (67%)
Apr 26, 2026 - MLB
Apr 25, 2026 - MLB
Apr 24, 2026 - MLB
Apr 15, 2026 - MLB
Apr 14, 2026 - MLB
Apr 13, 2026 - MLB
4/6 (67%)
2/6 (33%)
Apr 22, 2026 - MLB
Apr 21, 2026 - MLB
Apr 20, 2026 - MLB
Apr 19, 2026 - MLB
Apr 18, 2026 - MLB
Apr 17, 2026 - MLB
Pittsburgh Pirates against St. Louis Cardinals : Head to Head (H2H)
50 %
50 %
Mar 5, 2026 - MLB Spring Training
Mar 1, 2026 - MLB Spring Training
Aug 28, 2025 - MLB
Aug 27, 2025 - MLB
Aug 26, 2025 - MLB
Aug 25, 2025 - MLB
Pittsburgh Pirates - St. Louis Cardinals Key Points
- Pittsburgh leads the all-time series vs. the Cardinals 1281-1229-24.
- Pittsburgh is 17-11 ATS (run line) this season; St. Louis is 15-11.
- The OVER is 15-12 for the Pirates this season and 14-11-1 for the Cardinals.
- Betting Public: 23% of total tickets and 25% of the handle are on the UNDER.
Limited Offer. Currently at DraftKings
Our Pittsburgh Pirates vs St. Louis Cardinals Prediction
After a rocky start to the season, Dustin May appears to have gotten into a good groove. With how the Pirates have been hitting over the last week (.196, last in MLB), his outlook for today is promising. St. Louis has been hitting .253 but not scoring much, putting up 19 runs over the last week (five games). Pittsburgh’s bullpen has a 3.17 ERA so far this season, fifth best in baseball. So, I can see both teams struggling to put runs on the board today.
Our St. Louis vs. Pittsburgh Pick: UNDER 8
All tips are fully researched and given in good faith, but profits cannot be guaranteed.