New York Yankees vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

New York Yankees
8/5/26 19:05
St. Louis Cardinals

Prediction:

 

St. Louis Cardinals ML

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 by Matt Lowrimore in MLB Picks

Every MLB team will be in action on Wednesday, one of which will include an Interleague matchup between the New York Yankees and the St. Louis Cardinals. Let’s take a look at the match statistics and predictions for this game between the Yankees and the Cardinals.

St. Louis enters this game hovering under .500 and is currently in fourth place in the National League Central division. The Cardinals are set to start Andre Pallante for Game 2, who has a record of 11-6 and an ERA of 3.72. Pallante has also been excellent on the road this season, suggesting he will be able to slow down the Yankees in this matchup.

As for New York, they have one of the best records in the league, yet are currently in second place in the American League East division. Starting this game for the Yankees will be Will Warren, who has a record of 8-5 and an ERA of 4.14. While Warren has been serviceable when pitching at home, the Cardinals’ offense has already had a ton of success against Yankees’ pitching, and that could be the case in this game as well.

New York Yankees vs St. Louis Cardinals Form

Table

Teams Pts P W L
6 New York Yankees
0.561 114 64 50
16 St. Louis Cardinals
0.491 114 56 58

New York Yankees and St. Louis Cardinals Latest Matches

New York Yankees
New York Yankees Latest matches
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 4, 2026 - MLB

New York Yankees
2 :  0
St. Louis Cardinals

Aug 3, 2026 - MLB

New York Yankees
7 :  13
St. Louis Cardinals

Aug 2, 2026 - MLB

Chicago Cubs
1 :  2
New York Yankees

Aug 1, 2026 - MLB

Chicago Cubs
5 :  2
New York Yankees

Jul 31, 2026 - MLB

Chicago Cubs
0 :  2
New York Yankees

Jul 30, 2026 - MLB

Chicago White Sox
2 :  1
New York Yankees
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 4, 2026 - MLB

New York Yankees
2 :  0
St. Louis Cardinals

Aug 3, 2026 - MLB

New York Yankees
7 :  13
St. Louis Cardinals

Jul 22, 2026 - MLB

New York Yankees
2 :  0
Pittsburgh Pirates

Jul 22, 2026 - MLB

New York Yankees
3 :  5
Pittsburgh Pirates

Jul 20, 2026 - MLB

New York Yankees
8 :  5
Pittsburgh Pirates

Jul 19, 2026 - MLB

New York Yankees
2 :  1
Los Angeles Dodgers
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 2, 2026 - MLB

Chicago Cubs
1 :  2
New York Yankees

Aug 1, 2026 - MLB

Chicago Cubs
5 :  2
New York Yankees

Jul 31, 2026 - MLB

Chicago Cubs
0 :  2
New York Yankees

Jul 30, 2026 - MLB

Chicago White Sox
2 :  1
New York Yankees

Jul 29, 2026 - MLB

Chicago White Sox
6 :  5
New York Yankees

Jul 28, 2026 - MLB

Chicago White Sox
2 :  3
New York Yankees
St. Louis Cardinals
St. Louis Cardinals Latest matches
L L L W W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 4, 2026 - MLB

New York Yankees
2 :  0
St. Louis Cardinals

Aug 3, 2026 - MLB

New York Yankees
7 :  13
St. Louis Cardinals

Aug 2, 2026 - MLB

Toronto Blue Jays
1 :  5
St. Louis Cardinals

Aug 1, 2026 - MLB

Toronto Blue Jays
5 :  1
St. Louis Cardinals

Jul 31, 2026 - MLB

Toronto Blue Jays
3 :  1
St. Louis Cardinals

Jul 30, 2026 - MLB

St. Louis Cardinals
2 :  4
Chicago Cubs
W L L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 30, 2026 - MLB

St. Louis Cardinals
2 :  4
Chicago Cubs

Jul 29, 2026 - MLB

St. Louis Cardinals
3 :  2
Chicago Cubs

Jul 28, 2026 - MLB

St. Louis Cardinals
2 :  10
Chicago Cubs

Jul 27, 2026 - MLB

St. Louis Cardinals
3 :  7
Chicago Cubs

Jul 26, 2026 - MLB

St. Louis Cardinals
3 :  5
Cincinnati Reds

Jul 25, 2026 - MLB

St. Louis Cardinals
7 :  0
Cincinnati Reds
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 4, 2026 - MLB

New York Yankees
2 :  0
St. Louis Cardinals

Aug 3, 2026 - MLB

New York Yankees
7 :  13
St. Louis Cardinals

Aug 2, 2026 - MLB

Toronto Blue Jays
1 :  5
St. Louis Cardinals

Aug 1, 2026 - MLB

Toronto Blue Jays
5 :  1
St. Louis Cardinals

Jul 31, 2026 - MLB

Toronto Blue Jays
3 :  1
St. Louis Cardinals

Jul 22, 2026 - MLB

Los Angeles Angels
0 :  1
St. Louis Cardinals

New York Yankees against St. Louis Cardinals : Head to Head (H2H)

New York Yankees

80 %

St. Louis Cardinals

20 %

Aug 4, 2026 - MLB

New York Yankees
2 :  0
St. Louis Cardinals

Aug 3, 2026 - MLB

New York Yankees
7 :  13
St. Louis Cardinals

Aug 17, 2025 - MLB

St. Louis Cardinals
4 :  8
New York Yankees

Aug 16, 2025 - MLB

St. Louis Cardinals
8 :  12
New York Yankees

Aug 15, 2025 - MLB

St. Louis Cardinals
3 :  4
New York Yankees
New York Yankees vs St. Louis Cardinals Picks

New York Yankees - St. Louis Cardinals Key Points

  1. Andre Pallante has an ERA of 3.72 this season
  2. Andre Pallante has an ERA of 2.66 on the road this season
  3. Will Warren has an ERA of 4.14 this season
  4. Will Warren has an ERA of 3.75 at home this season

Our New York Yankees vs St. Louis Cardinals Prediction

As expected, the Yankees are once again the favorite in this game; however, the Cardinals look to be the best betting option. This is because of the home/away splits between the two starting pitchers. Most notably, Pallante has made eight away starts this season, in which he has allowed 13 earned runs over 44.0 innings. Warren, on the other hand, has made 10 home appearances (nine starts), where he has allowed 29 runs (20 earned) over 48.0 innings.

Overall, the Cardinals have only been average this season, but with one of their best pitchers on the mound, our New York Yankees vs St. Louis Cardinals prediction is: St. Louis Cardinals ML.

Prediction:

 

St. Louis Cardinals ML

+129
$150 offered for betting!

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.