New York Yankees vs St. Louis Cardinals Prediction & Picks - MLB
USA - MLB
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Matt Lowrimore | in MLB Picks
Every MLB team will be in action on Tuesday, one of which will include an Interleague matchup between the New York Yankees and the St. Louis Cardinals. Let’s take a look at the match statistics and predictions for this game between the Yankees and the Cardinals.
St. Louis enters this game hovering under .500 and is currently in fourth place in the National League Central division. The Cardinals are set to start Andre Pallante for Game 2, who has a record of 11-6 and an ERA of 3.72. Pallante has also been excellent on the road this season, suggesting he will be able to slow down the Yankees in this matchup.
As for New York, they have one of the best records in the league, yet are currently in second place in the American League East division. Starting this game for the Yankees will be Ryan Weathers, who has a record of 4-7 and an ERA of 3.99. The problem with Weathers is that he has not been consistent when pitching at home, which gives an advantage to the Cardinals.
Limited Offer. Currently at FanDuel
New York Yankees vs St. Louis Cardinals Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
6
|
0.558 | 113 | 63 | 50 |
|
16
|
0.496 | 113 | 56 | 57 |
New York Yankees and St. Louis Cardinals Latest Matches
2/6 (33%)
4/6 (67%)
Aug 3, 2026 - MLB
Aug 2, 2026 - MLB
Aug 1, 2026 - MLB
Jul 31, 2026 - MLB
Jul 30, 2026 - MLB
Jul 29, 2026 - MLB
3/6 (50%)
3/6 (50%)
Aug 3, 2026 - MLB
Jul 22, 2026 - MLB
Jul 22, 2026 - MLB
Jul 20, 2026 - MLB
Jul 19, 2026 - MLB
Jul 19, 2026 - MLB
3/6 (50%)
3/6 (50%)
Aug 2, 2026 - MLB
Aug 1, 2026 - MLB
Jul 31, 2026 - MLB
Jul 30, 2026 - MLB
Jul 29, 2026 - MLB
Jul 28, 2026 - MLB
3/6 (50%)
3/6 (50%)
Aug 3, 2026 - MLB
Aug 2, 2026 - MLB
Aug 1, 2026 - MLB
Jul 31, 2026 - MLB
Jul 30, 2026 - MLB
Jul 29, 2026 - MLB
2/6 (33%)
4/6 (67%)
Jul 30, 2026 - MLB
Jul 29, 2026 - MLB
Jul 28, 2026 - MLB
Jul 27, 2026 - MLB
Jul 26, 2026 - MLB
Jul 25, 2026 - MLB
3/6 (50%)
3/6 (50%)
Aug 3, 2026 - MLB
Aug 2, 2026 - MLB
Aug 1, 2026 - MLB
Jul 31, 2026 - MLB
Jul 22, 2026 - MLB
Jul 21, 2026 - MLB
New York Yankees against St. Louis Cardinals : Head to Head (H2H)
75 %
25 %
Aug 3, 2026 - MLB
Aug 17, 2025 - MLB
Aug 16, 2025 - MLB
Aug 15, 2025 - MLB
New York Yankees - St. Louis Cardinals Key Points
- Andre Pallante has an ERA of 3.72 this season
- Andre Pallante has an ERA of 2.66 on the road this season
- Ryan Weathers has an ERA of 3.99 this season
- Ryan Weathers has an ERA of 4.50 at home this season
Limited Offer. Currently at FanDuel
Our New York Yankees vs St. Louis Cardinals Prediction
It is no surprise the Yankees are the heavy favorite in this game. That said, the Cardinals look to be the best betting option. This is because of the home/away splits between the two starting pitchers. Pallante has made eight away starts this season, having allowed 13 earned runs over 44.0 innings. Weathers, on the other hand, has made 12 home starts this season, in which he has allowed 37 runs (32 earned) over 64.0 innings.
The Yankees may be the better overall team with the more consistent offense, but Weathers’ struggles at home cannot be ignored. For that reason, our New York Yankees vs St. Louis Cardinals prediction is: St. Louis Cardinals ML.
Welcome Bonus for the New York Yankees vs St. Louis Cardinals match!

The MLB season is in full swing and FanDuel is offering some great promos during the season, including their welcome offer of $1000, which can be activated for this New York Yankees vs St. Louis Cardinals match! Simply sign up and place a first bet of at least $5. In case your be loses, FanDuel will issue you the amount of your wager (up to $200 max) as a bet reset token. You can do this during your first 5 days with FanDuel, earning a total of $1000 in bet reset tokens!
Remember, the offer is only open to new sign-ups!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.