New York Yankees vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

New York Yankees
8/4/26 19:05
St. Louis Cardinals

Prediction:

 

St. Louis Cardinals ML

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 by Matt Lowrimore | in MLB Picks

Every MLB team will be in action on Tuesday, one of which will include an Interleague matchup between the New York Yankees and the St. Louis Cardinals. Let’s take a look at the match statistics and predictions for this game between the Yankees and the Cardinals.

St. Louis enters this game hovering under .500 and is currently in fourth place in the National League Central division. The Cardinals are set to start Andre Pallante for Game 2, who has a record of 11-6 and an ERA of 3.72. Pallante has also been excellent on the road this season, suggesting he will be able to slow down the Yankees in this matchup.

As for New York, they have one of the best records in the league, yet are currently in second place in the American League East division. Starting this game for the Yankees will be Ryan Weathers, who has a record of 4-7 and an ERA of 3.99. The problem with Weathers is that he has not been consistent when pitching at home, which gives an advantage to the Cardinals.

New York Yankees vs St. Louis Cardinals Form

Table

Teams Pts P W L
6 New York Yankees
0.558 113 63 50
16 St. Louis Cardinals
0.496 113 56 57

New York Yankees and St. Louis Cardinals Latest Matches

New York Yankees
New York Yankees Latest matches
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 3, 2026 - MLB

New York Yankees
7 :  13
St. Louis Cardinals

Aug 2, 2026 - MLB

Chicago Cubs
1 :  2
New York Yankees

Aug 1, 2026 - MLB

Chicago Cubs
5 :  2
New York Yankees

Jul 31, 2026 - MLB

Chicago Cubs
0 :  2
New York Yankees

Jul 30, 2026 - MLB

Chicago White Sox
2 :  1
New York Yankees

Jul 29, 2026 - MLB

Chicago White Sox
6 :  5
New York Yankees
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 3, 2026 - MLB

New York Yankees
7 :  13
St. Louis Cardinals

Jul 22, 2026 - MLB

New York Yankees
2 :  0
Pittsburgh Pirates

Jul 22, 2026 - MLB

New York Yankees
3 :  5
Pittsburgh Pirates

Jul 20, 2026 - MLB

New York Yankees
8 :  5
Pittsburgh Pirates

Jul 19, 2026 - MLB

New York Yankees
2 :  1
Los Angeles Dodgers

Jul 19, 2026 - MLB

New York Yankees
2 :  8
Los Angeles Dodgers
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 2, 2026 - MLB

Chicago Cubs
1 :  2
New York Yankees

Aug 1, 2026 - MLB

Chicago Cubs
5 :  2
New York Yankees

Jul 31, 2026 - MLB

Chicago Cubs
0 :  2
New York Yankees

Jul 30, 2026 - MLB

Chicago White Sox
2 :  1
New York Yankees

Jul 29, 2026 - MLB

Chicago White Sox
6 :  5
New York Yankees

Jul 28, 2026 - MLB

Chicago White Sox
2 :  3
New York Yankees
St. Louis Cardinals
St. Louis Cardinals Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 3, 2026 - MLB

New York Yankees
7 :  13
St. Louis Cardinals

Aug 2, 2026 - MLB

Toronto Blue Jays
1 :  5
St. Louis Cardinals

Aug 1, 2026 - MLB

Toronto Blue Jays
5 :  1
St. Louis Cardinals

Jul 31, 2026 - MLB

Toronto Blue Jays
3 :  1
St. Louis Cardinals

Jul 30, 2026 - MLB

St. Louis Cardinals
2 :  4
Chicago Cubs

Jul 29, 2026 - MLB

St. Louis Cardinals
3 :  2
Chicago Cubs
W L L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 30, 2026 - MLB

St. Louis Cardinals
2 :  4
Chicago Cubs

Jul 29, 2026 - MLB

St. Louis Cardinals
3 :  2
Chicago Cubs

Jul 28, 2026 - MLB

St. Louis Cardinals
2 :  10
Chicago Cubs

Jul 27, 2026 - MLB

St. Louis Cardinals
3 :  7
Chicago Cubs

Jul 26, 2026 - MLB

St. Louis Cardinals
3 :  5
Cincinnati Reds

Jul 25, 2026 - MLB

St. Louis Cardinals
7 :  0
Cincinnati Reds
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 3, 2026 - MLB

New York Yankees
7 :  13
St. Louis Cardinals

Aug 2, 2026 - MLB

Toronto Blue Jays
1 :  5
St. Louis Cardinals

Aug 1, 2026 - MLB

Toronto Blue Jays
5 :  1
St. Louis Cardinals

Jul 31, 2026 - MLB

Toronto Blue Jays
3 :  1
St. Louis Cardinals

Jul 22, 2026 - MLB

Los Angeles Angels
0 :  1
St. Louis Cardinals

Jul 21, 2026 - MLB

Los Angeles Angels
5 :  1
St. Louis Cardinals

New York Yankees against St. Louis Cardinals : Head to Head (H2H)

New York Yankees

75 %

St. Louis Cardinals

25 %

Aug 3, 2026 - MLB

New York Yankees
7 :  13
St. Louis Cardinals

Aug 17, 2025 - MLB

St. Louis Cardinals
4 :  8
New York Yankees

Aug 16, 2025 - MLB

St. Louis Cardinals
8 :  12
New York Yankees

Aug 15, 2025 - MLB

St. Louis Cardinals
3 :  4
New York Yankees
New York Yankees vs St. Louis Cardinals Picks

New York Yankees - St. Louis Cardinals Key Points

  1. Andre Pallante has an ERA of 3.72 this season
  2. Andre Pallante has an ERA of 2.66 on the road this season
  3. Ryan Weathers has an ERA of 3.99 this season
  4. Ryan Weathers has an ERA of 4.50 at home this season

Our New York Yankees vs St. Louis Cardinals Prediction

It is no surprise the Yankees are the heavy favorite in this game. That said, the Cardinals look to be the best betting option. This is because of the home/away splits between the two starting pitchers. Pallante has made eight away starts this season, having allowed 13 earned runs over 44.0 innings. Weathers, on the other hand, has made 12 home starts this season, in which he has allowed 37 runs (32 earned) over 64.0 innings.

The Yankees may be the better overall team with the more consistent offense, but Weathers’ struggles at home cannot be ignored. For that reason, our New York Yankees vs St. Louis Cardinals prediction is: St. Louis Cardinals ML.

Prediction:

 

St. Louis Cardinals ML

+140
$1000 offered for betting!

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.