Minnesota Twins vs St. Louis Cardinals Prediction & Picks - MLB

Prediction published on 6/13/26, 10:13 AM  by Lou Aguila in MLB Picks

The St. Louis Cardinals will try to return to the winner’s circle when they take on the Minnesota Twins in Game 2 of their series.

Momentum: After racking up six wins in a row, the St. Louis Cardinals have absorbed back-to-back heartbreaks at the hands of the New York Mets 4-5, and the Minnesota Twins 8-9. Meanwhile, the Twins have won 2 of their last 3 games, keeping them in third in the American League Central standings with a 32-39 slate.

The Matchup: Minnesota’s win on Friday snapped its four-game losing streak against the Cardinals. St. Louis is 6-4 in its last 10 meetings with Minnesota.

Starting Pitchers: Twins LHP Connor Prielipp (2-4, 5.51 ERA) has gone 2-3 with a 6.57 ERA over his last five starts. Prielipp surrendered two earned runs over 4.1 innings in a 5-6 loss to the Royals on June 7. Before his last mound appearance, Prielipp had experienced a rough stretch where he surrendered 16 earned runs across three consecutive starts.

Cardinals LHP Matthew Liberatore has maintained a 5.18 ERA over his last five starts. Despite Liberatore’s subpar numbers, the Cardinals managed to claim 3 wins in his last four starts.

Hot on the Board: Caesars Sportsbooks has not established a favorite ahead of Game 2, with both the Cardinals and Twins sitting at -110 moneyline.

However, St. Louis catches a lucrative +158 price on the -1.5 run line. This betting line should catch the attention of hardcore bettors playing for a huge payout since the Cards have become a road cash cow this year with a 21-11 ATS record in 32 road games.