Minnesota Twins vs St. Louis Cardinals Prediction & Picks - MLB

Prediction published on 6/11/26, 5:39 PM  by Carlos Zabala | Modified on 6/11/26 at 6:13 PM in MLB Picks

The Cardinals and Twins both lost their previous series on Thursday. They begin a new weekend series against each other, with Kyle Leahy facing off against Joe Ryan in the first pitching matchup. Minnesota is favored in pre-game betting at -135 odds, despite losing 0-11 to the Tigers the previous day.

Perhaps the Twins' favoritism stems from Ryan's solid performance in his last outing, which ended in a 1-1 tie after he threw 102 pitches and received a no-decision. He's looking to secure his fifth win of the season.

The Cardinals played an excellent game on Thursday, ultimately losing 4-5. However, it was a more positive series for St. Louis in New York, as they won the first two games against the Mets. They had previously swept the Reds at home, and in June, when they hit six consecutive home runs, homers have been plentiful. On Thursday, despite the loss, Burleson kept up his strong play, hitting his 11th home run of the year; Nootbaar connected for his second, and Crooks for his first.