Milwaukee Brewers vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

Milwaukee Brewers
9/26/26 19:10
St. Louis Cardinals

Prediction:

 

Brewers ML

−192
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 by Travis Pulver | in MLB Picks

The Milwaukee Brewers (101-59, 53-26 Home) will host the St. Louis Cardinals (77-83, 39-40 Away) today at American Family Field at 7:10 p.m. EST with coverage provided by MLB.TV.

Milwaukee has already secured the best record in baseball this season with the franchise’s first 100+ win season. With an 8-4 win over the Cardinals yesterday, they’ve won three in a row and eight of their last 10.

Dustin May is scheduled to start for the Brewers. He has gone 7-9 this season in 30 starts, posting a 4.67 ERA and a 1.32 WHIP. Teams have hit .256 against him this season. Since joining the Brewers, he has posted a 2-2 record in nine starts with a 5.61 ERA and a 1.43 WHIP.

St. Louis is expected to hand the ball to Quinn Matthews to start the day. Matthews has gone 2-3 in eight starts with a 3.65 ERA and a 1.38 WHIP. Teams have hit .257 against him. He has not been great on the road, where he is 0-3 in five starts with a 4.68 ERA and a .273 OBA. But through four starts in September, he has a 1-1 record with a 2.55 ERA and a .225 OBA.

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Milwaukee Brewers vs St. Louis Cardinals Form

Table

Teams Pts P W L
1 Milwaukee Brewers
0.636 162 103 59
19 St. Louis Cardinals
0.475 162 77 85

Milwaukee Brewers and St. Louis Cardinals Latest Matches

Milwaukee Brewers
Milwaukee Brewers Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 25, 2026 - MLB

Milwaukee Brewers
8 :  4
St. Louis Cardinals

Sep 24, 2026 - MLB

Philadelphia Phillies
1 :  5
Milwaukee Brewers

Sep 23, 2026 - MLB

Philadelphia Phillies
1 :  4
Milwaukee Brewers

Sep 22, 2026 - MLB

Philadelphia Phillies
6 :  4
Milwaukee Brewers

Sep 20, 2026 - MLB

Baltimore Orioles
0 :  3
Milwaukee Brewers

Sep 19, 2026 - MLB

Baltimore Orioles
0 :  1
Milwaukee Brewers
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 25, 2026 - MLB

Milwaukee Brewers
8 :  4
St. Louis Cardinals

Sep 13, 2026 - MLB

Milwaukee Brewers
3 :  4
Cincinnati Reds

Sep 12, 2026 - MLB

Milwaukee Brewers
13 :  9
Cincinnati Reds

Sep 11, 2026 - MLB

Milwaukee Brewers
20 :  0
Cincinnati Reds

Sep 9, 2026 - MLB

Milwaukee Brewers
8 :  6
Chicago Cubs

Sep 8, 2026 - MLB

Milwaukee Brewers
4 :  3
Chicago Cubs
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 24, 2026 - MLB

Philadelphia Phillies
1 :  5
Milwaukee Brewers

Sep 23, 2026 - MLB

Philadelphia Phillies
1 :  4
Milwaukee Brewers

Sep 22, 2026 - MLB

Philadelphia Phillies
6 :  4
Milwaukee Brewers

Sep 20, 2026 - MLB

Baltimore Orioles
0 :  3
Milwaukee Brewers

Sep 19, 2026 - MLB

Baltimore Orioles
0 :  1
Milwaukee Brewers

Sep 18, 2026 - MLB

Baltimore Orioles
5 :  6
Milwaukee Brewers
St. Louis Cardinals
St. Louis Cardinals Latest matches
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 25, 2026 - MLB

Milwaukee Brewers
8 :  4
St. Louis Cardinals

Sep 24, 2026 - MLB

Pittsburgh Pirates
2 :  1
St. Louis Cardinals

Sep 23, 2026 - MLB

Pittsburgh Pirates
1 :  5
St. Louis Cardinals

Sep 22, 2026 - MLB

Pittsburgh Pirates
2 :  0
St. Louis Cardinals

Sep 20, 2026 - MLB

St. Louis Cardinals
5 :  3
Washington Nationals

Sep 19, 2026 - MLB

St. Louis Cardinals
5 :  8
Washington Nationals
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 20, 2026 - MLB

St. Louis Cardinals
5 :  3
Washington Nationals

Sep 19, 2026 - MLB

St. Louis Cardinals
5 :  8
Washington Nationals

Sep 18, 2026 - MLB

St. Louis Cardinals
1 :  9
Washington Nationals

Sep 16, 2026 - MLB

St. Louis Cardinals
5 :  6
San Francisco Giants

Sep 15, 2026 - MLB

St. Louis Cardinals
3 :  10
San Francisco Giants

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 25, 2026 - MLB

Milwaukee Brewers
8 :  4
St. Louis Cardinals

Sep 24, 2026 - MLB

Pittsburgh Pirates
2 :  1
St. Louis Cardinals

Sep 23, 2026 - MLB

Pittsburgh Pirates
1 :  5
St. Louis Cardinals

Sep 22, 2026 - MLB

Pittsburgh Pirates
2 :  0
St. Louis Cardinals

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals

Milwaukee Brewers against St. Louis Cardinals : Head to Head (H2H)

Milwaukee Brewers

83 %

St. Louis Cardinals

17 %

Sep 25, 2026 - MLB

Milwaukee Brewers
8 :  4
St. Louis Cardinals

Jul 9, 2026 - MLB

St. Louis Cardinals
4 :  8
Milwaukee Brewers

Jul 8, 2026 - MLB

St. Louis Cardinals
5 :  1
Milwaukee Brewers

Jul 7, 2026 - MLB

St. Louis Cardinals
2 :  10
Milwaukee Brewers

Jul 7, 2026 - MLB

St. Louis Cardinals
3 :  4
Milwaukee Brewers

Jul 6, 2026 - MLB

St. Louis Cardinals
3 :  4
Milwaukee Brewers
Milwaukee Brewers vs St. Louis Cardinals Picks

Milwaukee Brewers - St. Louis Cardinals Key Points

  1. Milwaukee has gone 24-13 vs. the Cardinals over the last three seasons.
  2. The Brewers have gone 45-33 ATS (run line) at home this season; the Cardinals have gone 43-36 ATS (run line) on the road.
  3. The OVER is 34-42-2 for Milwaukee at home and 37-38-4 for St. Louis on the road.
  4. Betting Public: 87% of moneyline tickets and 71% of the handle are on the Brewers.

Our Milwaukee Brewers vs St. Louis Cardinals Prediction

I am not a Dustin May fan, but his recent history shows the team has no problem pulling him early before too much damage can be done. However, with the Cardinals hitting only .207 over the last week, there may not be much to worry about, anyway. While Matthews has shown some promise, you have to be concerned about his performance away from home. Milwaukee is having an incredible season, winning 100+ games for the first time in franchise history. With neither team having a clear-cut edge according to recent stats, I feel like I have to go with the Brewers simply because they have been the best team in baseball all season. Even when they don’t look great on paper, they find a way to win.

Our St. Louis vs. Milwaukee Pick: Brewers ML

Prediction:

 

Brewers ML

−192
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.