Miami Marlins vs St. Louis Cardinals Prediction & Picks - MLB

Prediction published on 4/22/26, 8:12 AM  by Carlos Zabala | Modified on 4/22/26 at 6:50 PM in MLB Picks

Things are going well for the Cardinals: after sweeping the Astros, they're in Miami, and after winning the second game of the series 5-3—after losing the first 3-5—they'll play the series-deciding game against the "Fighting Fish" this afternoon. Early betting action has the Marlins as -125 favorites for Wednesday's game.

Tuesday's game featured a pitching matchup between Dustin May and Chris Paddack; the Cardinals' redhead had a forgettable start to the season, from which he has now fully recovered. He and the bullpen kept the Marlins' lineup in check, with the exceptions of Marsee and Edwards, who combined for a 5-for-8.

For St. Louis, the home runs are coming at crucial moments; Nathan Church hit his second home run of the season, driving in Winn. He, Herrera, Burleson, and Winn all had multi-hit games on Tuesday.

As for the Marlins, some were right when they warned that their start to the season was a mirage, as they had looked good, but when they faced the Rockies and White Sox... The statistics show that, although they are doing things well, they are already falling behind the rest of MLB in home runs. It's also worth noting that, although the team has a decent batting average, Marsee, Hernández, and Pauley are not batting above .160.