Kansas City Royals vs St. Louis Cardinals Prediction & Picks - MLB

Prediction published on 5/16/25, 4:10 PM  by Carlos Zabala | Modified on 5/16/25 at 10:45 PM in MLB Picks

In early betting action, the Royals started as -160 favorites, but their favorability to open the series against the Cardinals has slipped slightly and is now hovering around -155. Several factors contribute to these odds. Before losing the series to the Astros, the Royals were one of the hottest teams in MLB and returned home with a tremendous solid showing at Kauffman Stadium, where they hold a 16-7 record. Meanwhile, the Cardinals, despite having a 24-20 record, are only 9-14 away from Busch Stadium.

In terms of betting, both teams are without lucrative teams, and betting $100 on the ML for each Cardinals or Royals game would have generated profits in both cases.

Pallante is the pitcher scheduled by the Cardinals to open the series; he has a 3-2 record and a 4.36 ERA. Although Ragans, the Royals' starter, has similar numbers, an ERA of 4.21 and a record of 2-2.