Houston Astros vs St. Louis Cardinals Prediction & Picks - MLB
USA - MLB
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The Houston Astros will be hoping for a change in fortunes on Sunday night, as they take on the St Louis Cardinals in the final matchup of their three game series.
The Cardinals have held the upper hand in what has been a very high scoring series so far; A Nolan Gorman three run homer proved to be the difference-maker for the Cards in their 9-4 Game One succes, whilst homers from José Fermín and Alec Burleson, plus a Masyn Winn double enabled St Louis to register a 7-5 Game Two victory on Saturday night that was far more comfortable than the scoreline suggests.
Those victories have moved the Cardinals to 10-8 for the season, whilst the Astros have dropped to 8-12.
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Houston Astros vs St. Louis Cardinals Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
12
|
0.504 | 119 | 60 | 59 |
|
14
|
0.5 | 118 | 59 | 59 |
Houston Astros and St. Louis Cardinals Latest Matches
2/6 (33%)
4/6 (67%)
Apr 18, 2026 - MLB
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3/6 (50%)
3/6 (50%)
Apr 18, 2026 - MLB
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Apr 1, 2026 - MLB
0/6 (0%)
6/6 (100%)
Apr 13, 2026 - MLB
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Apr 7, 2026 - MLB
4/6 (67%)
2/6 (33%)
Apr 18, 2026 - MLB
Apr 17, 2026 - MLB
Apr 15, 2026 - MLB
Apr 14, 2026 - MLB
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Apr 12, 2026 - MLB
3/6 (50%)
3/6 (50%)
Apr 15, 2026 - MLB
Apr 14, 2026 - MLB
Apr 13, 2026 - MLB
Apr 12, 2026 - MLB
Apr 11, 2026 - MLB
Apr 10, 2026 - MLB
5/6 (83%)
1/6 (17%)
Apr 18, 2026 - MLB
Apr 17, 2026 - MLB
Apr 8, 2026 - MLB
Apr 7, 2026 - MLB
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Apr 5, 2026 - MLB
Houston Astros against St. Louis Cardinals : Head to Head (H2H)
17 %
83 %
Apr 18, 2026 - MLB
Apr 17, 2026 - MLB
Mar 22, 2026 - MLB Spring Training
Mar 18, 2026 - MLB Spring Training
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Mar 9, 2026 - MLB Spring Training
Houston Astros - St. Louis Cardinals Key Points
- There have been over 10.5 runs in 5 of the Cardinals' last 6 games
- There have been 25 runs in the opening 2 games of the series
- The Astros have the 5th highest batting average in MLB this season
- The Cardinals have scored 16 runs in the first 2 games of the series
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Our Houston Astros vs St. Louis Cardinals Prediction
Despite the Cards' 2-0 series advantage, we're sterring clear of the moneyline here and instead focussing on the total runs markets.
It's early days in the 2026 MLB season, but it is already clear to see that both the Astros and Cards need to make big improvements at pitcher if they want to be able to chellenge the top teams in the league.
As such, we are fully expectiing Sunday night's game to follow the pattern of the first two games of the series and feature plenty of runs from both sides.
Our prediction for Houston Astros vs St Louis Cardinals is: Over 10.5 runs.
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