Houston Astros vs St. Louis Cardinals Prediction & Picks - MLB
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by Matt Lowrimore | in MLB Picks
A full 15-game slate is scheduled in the MLB on Friday, and will include an interleague matchup between the Houston Astros and the St. Louis Cardinals. Let’s take a look at the match statistics and predictions for this game between the Astros and the Cardinals.
St. Louis has been mediocre to start the season, but they did just take two out of three from the Cleveland Guardians. The Cardinals are now set to start Kyle Leahy for Game 1 of this series against the Astros. Leahy has a record of 1-2 this season and an ERA of 5.14. Through three starts this season, Leahy has allowed eight earned runs over 14.0 innings and at least two in all three of his starts.
As for Houston, they have been extremely inconsistent to start the season. The Astros just lost to the Colorado Rockies on Thursday, and are 2-8 in their last 10 games. Looking to bounce back in Game 1 against the Cardinals, the Astros will start Peter Lambert. He has not pitched in the MLB since 2024, when he was with the Colorado Rockies. In that season, he posted a record of 2-5 and had an ERA of 5.72.
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Houston Astros vs St. Louis Cardinals Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
11
|
0.525 | 80 | 42 | 38 |
|
18
|
0.482 | 85 | 41 | 44 |
Houston Astros and St. Louis Cardinals Latest Matches
2/6 (33%)
4/6 (67%)
Apr 16, 2026 - MLB
Apr 15, 2026 - MLB
Apr 14, 2026 - MLB
Apr 13, 2026 - MLB
Apr 12, 2026 - MLB
Apr 11, 2026 - MLB
5/6 (83%)
1/6 (17%)
Apr 16, 2026 - MLB
Apr 15, 2026 - MLB
Apr 14, 2026 - MLB
Apr 1, 2026 - MLB
Mar 31, 2026 - MLB
Mar 30, 2026 - MLB
0/6 (0%)
6/6 (100%)
Apr 13, 2026 - MLB
Apr 12, 2026 - MLB
Apr 11, 2026 - MLB
Apr 10, 2026 - MLB
Apr 8, 2026 - MLB
Apr 7, 2026 - MLB
3/6 (50%)
3/6 (50%)
Apr 15, 2026 - MLB
Apr 14, 2026 - MLB
Apr 13, 2026 - MLB
Apr 12, 2026 - MLB
Apr 11, 2026 - MLB
Apr 10, 2026 - MLB
3/6 (50%)
3/6 (50%)
Apr 15, 2026 - MLB
Apr 14, 2026 - MLB
Apr 13, 2026 - MLB
Apr 12, 2026 - MLB
Apr 11, 2026 - MLB
Apr 10, 2026 - MLB
3/6 (50%)
3/6 (50%)
Apr 8, 2026 - MLB
Apr 7, 2026 - MLB
Apr 6, 2026 - MLB
Apr 5, 2026 - MLB
Apr 4, 2026 - MLB
Apr 3, 2026 - MLB
Houston Astros against St. Louis Cardinals : Head to Head (H2H)
17 %
83 %
Mar 22, 2026 - MLB Spring Training
Mar 18, 2026 - MLB Spring Training
Mar 13, 2026 - MLB Spring Training
Mar 9, 2026 - MLB Spring Training
Feb 26, 2026 - MLB Spring Training
Feb 22, 2026 - MLB Spring Training
Houston Astros - St. Louis Cardinals Key Points
- Kyle Leahy has an ERA of 5.14
- St. Louis is averaging 4.44 runs per game
- Houston is averaging 5.35 runs per game
- Peter Lambert had an ERA of 5.72 in 2024
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Our Houston Astros vs St. Louis Cardinals Prediction
Somehow, the Astros are the favorites to win this game; however, the over looks to be the best betting option. If there is one thing the Astros have been good at this season, it is scoring runs. Houston is averaging 5.35 runs per game, but has generally been unable to hold leads due to their lackluster pitching.
St. Louis, on the other hand, also has a solid offense, averaging 4.44 runs per game. Just like Houston, their pitching staff has struggled, and they have a team ERA of 4.94. Therefore, because both teams have allowed a ton of runs, our Houston Astros vs St. Louis Cardinals prediction is: Over 8.5 Total Runs.All tips are fully researched and given in good faith, but profits cannot be guaranteed.
