Detroit Tigers vs St. Louis Cardinals Prediction & Picks - MLB

Prediction published on 4/4/26, 9:35 AM  by Carlos Zabala | Modified on 4/5/26 at 1:50 AM in MLB Picks

The Tigers completed a successful home opener at Comerica Park, winning their first game of the year in Detroit against the Cardinals 4-0. It was the hottest home opener in franchise history since 2000, with the thermometer reaching 71 degrees Fahrenheit.

Ultimately, the Tigers continued their historic dominance against the Cardinals; against no other team than St. Louis do the felines have a better winning percentage. Dillon Dingler hit a two-run homer, Greene drove in Torres with a single, and Báez did the same for Meadows in the eighth inning.

The Cardinals were coming off a series of relatively low hitting against the Mets, a stark contrast to their first series against the Rays, where they hit several home runs. Framer Valdez dominated them on Friday at Comerica Park, pitching six scoreless innings and allowing only three hits.

Flaherty will now pitch his second start of the year with the Tigers, as will Dustin May against the Cardinals, but the latter was battered by the Rays, allowing 10 hits and 6 earned runs in 4 innings of work in his first start.