Detroit Tigers vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

Detroit Tigers
4/3/26 13:10
St. Louis Cardinals

Prediction:

 

St. Louis Cardinals ML

+144
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 by Matt Lowrimore | in MLB Picks

A full 15-game MLB slate is scheduled for Friday, which will include an interleague matchup between the Detroit Tigers (2-4) and the St. Louis Cardinals (4-2). Let’s take a look at the match statistics and predictions for this game between the Tigers and the Cardinals.

St. Louis has started the season strong, winning both of their first two series against the Tampa Bay Rays and the New York Mets. To open this series in Detroit, the Cardinals are scheduled to start Michael McGreevy. He will be making his second start of the season, and does so with an ERA of 0.00. In his first start against Tampa Bay, McGreevy went 6.0 innings and did not allow an earned run. 

As for Detroit, they opened the season with two out of three wins against the San Diego Padres, but were just swept by the Arizona Diamondbacks. The Tigers are set to start Framber Valdez, who comes into his second start with an ERA of 1.50. In his first start against San Diego, Valdez went 6.0 innings and allowed two runs (one earned). As strong as he was, Detroit’s bullpen has an ERA of 5.82 so far this season, which could spell trouble for them.

Detroit Tigers vs St. Louis Cardinals Form

Table

Teams Pts P W L
11 St. Louis Cardinals
0.525 80 42 38
25 Detroit Tigers
0.422 83 35 48

Detroit Tigers and St. Louis Cardinals Latest Matches

Detroit Tigers
Detroit Tigers Latest matches
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 1, 2026 - MLB

Arizona Diamondbacks
1 :  0
Detroit Tigers

Mar 31, 2026 - MLB

Arizona Diamondbacks
7 :  5
Detroit Tigers

Mar 30, 2026 - MLB

Arizona Diamondbacks
9 :  6
Detroit Tigers

Mar 28, 2026 - MLB

San Diego Padres
3 :  0
Detroit Tigers

Mar 27, 2026 - MLB

San Diego Padres
2 :  5
Detroit Tigers

Mar 26, 2026 - MLB

San Diego Padres
2 :  8
Detroit Tigers
D L L W D W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Mar 21, 2026 - MLB Spring Training

Detroit Tigers
3 :  1
New York Yankees

Mar 17, 2026 - MLB Spring Training

Detroit Tigers
1 :  1
Baltimore Orioles

Mar 16, 2026 - MLB Spring Training

Detroit Tigers
13 :  6
Philadelphia Phillies

Mar 13, 2026 - MLB Spring Training

Detroit Tigers
5 :  7
Pittsburgh Pirates

Mar 12, 2026 - MLB Spring Training

Detroit Tigers
3 :  4
New York Yankees

Mar 9, 2026 - MLB Spring Training

Detroit Tigers
4 :  4
Tampa Bay Rays
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 1, 2026 - MLB

Arizona Diamondbacks
1 :  0
Detroit Tigers

Mar 31, 2026 - MLB

Arizona Diamondbacks
7 :  5
Detroit Tigers

Mar 30, 2026 - MLB

Arizona Diamondbacks
9 :  6
Detroit Tigers

Mar 28, 2026 - MLB

San Diego Padres
3 :  0
Detroit Tigers

Mar 27, 2026 - MLB

San Diego Padres
2 :  5
Detroit Tigers

Mar 26, 2026 - MLB

San Diego Padres
2 :  8
Detroit Tigers
St. Louis Cardinals
St. Louis Cardinals Latest matches
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 1, 2026 - MLB

St. Louis Cardinals
2 :  1
New York Mets

Mar 31, 2026 - MLB

St. Louis Cardinals
3 :  0
New York Mets

Mar 30, 2026 - MLB

St. Louis Cardinals
2 :  4
New York Mets

Mar 29, 2026 - MLB

St. Louis Cardinals
7 :  11
Tampa Bay Rays

Mar 28, 2026 - MLB

St. Louis Cardinals
6 :  5
Tampa Bay Rays

Mar 26, 2026 - MLB

St. Louis Cardinals
9 :  7
Tampa Bay Rays
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 1, 2026 - MLB

St. Louis Cardinals
2 :  1
New York Mets

Mar 31, 2026 - MLB

St. Louis Cardinals
3 :  0
New York Mets

Mar 30, 2026 - MLB

St. Louis Cardinals
2 :  4
New York Mets

Mar 29, 2026 - MLB

St. Louis Cardinals
7 :  11
Tampa Bay Rays

Mar 28, 2026 - MLB

St. Louis Cardinals
6 :  5
Tampa Bay Rays

Mar 26, 2026 - MLB

St. Louis Cardinals
9 :  7
Tampa Bay Rays
L L D L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Mar 22, 2026 - MLB Spring Training

Houston Astros
2 :  3
St. Louis Cardinals

Mar 20, 2026 - MLB Spring Training

New York Mets
3 :  4
St. Louis Cardinals

Mar 17, 2026 - MLB Spring Training

Washington Nationals
1 :  0
St. Louis Cardinals

Mar 14, 2026 - MLB Spring Training

Miami Marlins
7 :  7
St. Louis Cardinals

Mar 11, 2026 - MLB Spring Training

Washington Nationals
3 :  1
St. Louis Cardinals

Mar 10, 2026 - MLB Spring Training

New York Mets
6 :  1
St. Louis Cardinals

Detroit Tigers against St. Louis Cardinals : Head to Head (H2H)

Detroit Tigers

100 %

St. Louis Cardinals

0 %

May 21, 2025 - MLB

St. Louis Cardinals
1 :  5
Detroit Tigers

May 20, 2025 - MLB

St. Louis Cardinals
4 :  5
Detroit Tigers

Apr 30, 2024 - MLB

Detroit Tigers
11 :  6
St. Louis Cardinals

Detroit Tigers - St. Louis Cardinals Key Points

  1. St. Louis is averaging 4.83 runs per game
  2. McGreevy has an ERA of 0.00
  3. Valdez has an ERA of 1.50
  4. Detroit is 0-3 SU in their last 3 games

Our Detroit Tigers vs St. Louis Cardinals Prediction

Detroit is the heavy favorite in this game; however, St. Louis looks to be the best betting option. The Tigers certainly look to have a strong starting pitcher in this game, that being Valdez, but where they could have issues is their shaky bullpen. The Detroit bullpen has already posted an ERA of nearly 6.00, which has cost them several times in just the first six games.

St. Louis’ bullpen, on the other hand, has been equally as bad, but the difference is that the Cardinals’ offense has been much more efficient. Given that St. Louis simply looks to have the slight edge in starting pitching, our Detroit Tigers vs St. Louis Cardinals prediction is: St. Louis Cardinals ML.

Prediction:

 

St. Louis Cardinals ML

+144
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Detroit Tigers vs St. Louis Cardinals Picks