Cincinnati Reds vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

Cincinnati Reds
5/22/26 18:40
St. Louis Cardinals

Prediction:

 

Over 9.5

−105
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 by Bill Christy | in MLB Picks

The Cincinnati Reds (26-24) will host the St. Louis Cardinals (28-21) for a 3-game set that will begin tonight. This will be the 1st series between the NL Central foes.

It has been a month of mediocrity for the Cardinals to this point. They are 10-8 on the month and have lost 3 of their last 4. They are coming off back-to-back losses to Pittsburgh, where they were outscored 13-2. The offense went silent after putting up 9 runs in the first game of the series. Luckily, they will get an opportunity to have an offensive breakout here against the opposing starting pitcher.

Chris Paddack will go for the Reds in this one. He is 0-5 with a 7.07 ERA on the season. He has given up multiple runs in 6 straight starts and saw this Cardinals team put up 5 in 4.2 innings of work the last time he faced this Cardinals team. That was when he was still with the Marlins, but it was a terrible outing nonetheless.

The Cardinals are throwing Kyle Leahy to oppose Paddack. He is 5-3 on the season and carries a sub-4.00 ERA. He has given up just 2 earned runs over his last 3 starts. If he can pitch well again, he should have plenty of run support in this one.

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Cincinnati Reds vs St. Louis Cardinals Form

Table

Teams Pts P W L
19 St. Louis Cardinals
0.475 162 77 85
24 Cincinnati Reds
0.463 162 75 87

Cincinnati Reds and St. Louis Cardinals Latest Matches

Cincinnati Reds
Cincinnati Reds Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 20, 2026 - MLB

Philadelphia Phillies
4 :  9
Cincinnati Reds

May 19, 2026 - MLB

Philadelphia Phillies
1 :  4
Cincinnati Reds

May 18, 2026 - MLB

Philadelphia Phillies
5 :  4
Cincinnati Reds

May 17, 2026 - MLB

Cleveland Guardians
10 :  3
Cincinnati Reds

May 16, 2026 - MLB

Cleveland Guardians
7 :  4
Cincinnati Reds

May 15, 2026 - MLB

Cleveland Guardians
6 :  7
Cincinnati Reds
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Cincinnati Reds
15 :  1
Washington Nationals

May 13, 2026 - MLB

Cincinnati Reds
7 :  8
Washington Nationals

May 12, 2026 - MLB

Cincinnati Reds
4 :  10
Washington Nationals

May 10, 2026 - MLB

Cincinnati Reds
5 :  0
Houston Astros

May 9, 2026 - MLB

Cincinnati Reds
3 :  1
Houston Astros

May 8, 2026 - MLB

Cincinnati Reds
0 :  10
Houston Astros
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 20, 2026 - MLB

Philadelphia Phillies
4 :  9
Cincinnati Reds

May 19, 2026 - MLB

Philadelphia Phillies
1 :  4
Cincinnati Reds

May 18, 2026 - MLB

Philadelphia Phillies
5 :  4
Cincinnati Reds

May 17, 2026 - MLB

Cleveland Guardians
10 :  3
Cincinnati Reds

May 16, 2026 - MLB

Cleveland Guardians
7 :  4
Cincinnati Reds

May 15, 2026 - MLB

Cleveland Guardians
6 :  7
Cincinnati Reds
St. Louis Cardinals
St. Louis Cardinals Latest matches
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 21, 2026 - MLB

St. Louis Cardinals
2 :  6
Pittsburgh Pirates

May 20, 2026 - MLB

St. Louis Cardinals
0 :  7
Pittsburgh Pirates

May 19, 2026 - MLB

St. Louis Cardinals
9 :  6
Pittsburgh Pirates

May 17, 2026 - MLB

St. Louis Cardinals
0 :  2
Kansas City Royals

May 16, 2026 - MLB

St. Louis Cardinals
4 :  2
Kansas City Royals

May 15, 2026 - MLB

St. Louis Cardinals
5 :  4
Kansas City Royals
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 21, 2026 - MLB

St. Louis Cardinals
2 :  6
Pittsburgh Pirates

May 20, 2026 - MLB

St. Louis Cardinals
0 :  7
Pittsburgh Pirates

May 19, 2026 - MLB

St. Louis Cardinals
9 :  6
Pittsburgh Pirates

May 17, 2026 - MLB

St. Louis Cardinals
0 :  2
Kansas City Royals

May 16, 2026 - MLB

St. Louis Cardinals
4 :  2
Kansas City Royals

May 15, 2026 - MLB

St. Louis Cardinals
5 :  4
Kansas City Royals
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Athletics
4 :  5
St. Louis Cardinals

May 13, 2026 - MLB

Athletics
6 :  2
St. Louis Cardinals

May 12, 2026 - MLB

Athletics
4 :  6
St. Louis Cardinals

May 10, 2026 - MLB

San Diego Padres
3 :  2
St. Louis Cardinals

May 9, 2026 - MLB

San Diego Padres
4 :  2
St. Louis Cardinals

May 8, 2026 - MLB

San Diego Padres
0 :  6
St. Louis Cardinals

Cincinnati Reds against St. Louis Cardinals : Head to Head (H2H)

Cincinnati Reds

17 %

St. Louis Cardinals

83 %

Aug 29, 2025 - MLB

Cincinnati Reds
5 :  7
St. Louis Cardinals

Jun 21, 2025 - MLB

St. Louis Cardinals
6 :  5
Cincinnati Reds

Jun 20, 2025 - MLB

St. Louis Cardinals
6 :  1
Cincinnati Reds

May 1, 2025 - MLB

Cincinnati Reds
9 :  1
St. Louis Cardinals

Apr 30, 2025 - MLB

Cincinnati Reds
1 :  9
St. Louis Cardinals

Apr 30, 2025 - MLB

Cincinnati Reds
0 :  6
St. Louis Cardinals
Cincinnati Reds vs St. Louis Cardinals Picks

Cincinnati Reds - St. Louis Cardinals Key Points

  1. The total has gone OVER in 18 of Cincinnati’s last 25 games.
  2. The total has gone OVER in 10 of Cincinnati’s last 12 games at home.
  3. The total has gone OVER in 4 of St. Louis’ last 5 games when playing on the road against Cincinnati.
  4. The total has gone OVER in 13 of St. Louis’ last 18 games played on a Friday when on the road.

Our Cincinnati Reds vs St. Louis Cardinals Prediction

While Leahy has been stellar lately, he is not invincible. He is due for a rough outing sooner or later. We believe it will be sooner here against the Reds. However, even if he does pitch well, we believe that the Cardinals can rough up Paddack just like they did when he was a member of the Miami Marlins a month ago. These teams are both ranked inside the top 15 in runs scored on the season. That should continue here in the opening game of the series.

Our prediction for Cincinnati Reds vs St. Louis Cardinals: Over 9.5

Prediction:

 

Over 9.5

−105
$200 offered for betting!

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