Chicago White Sox vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

Chicago White Sox
6/18/25 19:40
St. Louis Cardinals

Prediction:

 

Cardinals -180

-180
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 by Travis Pulver | in MLB Picks

The St. Louis Cardinals will take on the White Sox in the second game of a three-game series at Rate Field in Chicago, Illinois. Game time is scheduled for 7:40 p.m. EST.

St. Louis got the series off to a strong start with a 12-2 win over the White Sox in Game One yesterday. Matthew Liberatore pitched six solid innings (five hits, two runs), but the stars of the day were second baseman Brenden Donovan (4-5 with two runs scored and an RBI) and Ivan Herrera (2-5 with four RBI. The Cards recorded a run in six of nine innings. Chicago will hope for a better result with Sean Burke taking the mound to start the day. While Burke has a 4.71 ERA on the season, he has been decidedly better at home, where his ERA is 3.68 across seven outings. It will certainly help if he can get more than the six hits and two runs of support the lineup provided yesterday. St. Louis is scheduled to start Sonny Gray, who has a 3.68 ERA this season but a 5.88 ERA in road games (five). Opponents are hitting .284 against him in road games and .292 at night.

Chicago White Sox vs St. Louis Cardinals Form

Table

Teams Pts P W L
20 St. Louis Cardinals
0.481 162 78 84
29 Chicago White Sox
0.37 162 60 102

Chicago White Sox and St. Louis Cardinals Latest Matches

Chicago White Sox
Chicago White Sox Latest matches
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Jun 12, 2025 - MLB

Houston Astros
4 :  3
Chicago White Sox

Jun 11, 2025 - MLB

Houston Astros
10 :  2
Chicago White Sox

Jun 8, 2025 - MLB

Chicago White Sox
5 :  7
Kansas City Royals

Jun 7, 2025 - MLB

Chicago White Sox
4 :  1
Kansas City Royals

Jun 1, 2025 - MLB

Baltimore Orioles
3 :  2
Chicago White Sox

May 30, 2025 - MLB

Baltimore Orioles
2 :  1
Chicago White Sox
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 8, 2025 - MLB

Chicago White Sox
5 :  7
Kansas City Royals

Jun 7, 2025 - MLB

Chicago White Sox
4 :  1
Kansas City Royals

May 24, 2025 - MLB

Chicago White Sox
10 :  5
Texas Rangers

May 4, 2025 - MLB

Chicago White Sox
5 :  4
Houston Astros

May 3, 2025 - MLB

Chicago White Sox
3 :  8
Houston Astros

May 1, 2025 - MLB

Chicago White Sox
8 :  0
Milwaukee Brewers
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Jun 12, 2025 - MLB

Houston Astros
4 :  3
Chicago White Sox

Jun 11, 2025 - MLB

Houston Astros
10 :  2
Chicago White Sox

Jun 1, 2025 - MLB

Baltimore Orioles
3 :  2
Chicago White Sox

May 30, 2025 - MLB

Baltimore Orioles
2 :  1
Chicago White Sox

May 28, 2025 - MLB

New York Mets
4 :  9
Chicago White Sox

May 26, 2025 - MLB

New York Mets
2 :  1
Chicago White Sox
St. Louis Cardinals
St. Louis Cardinals Latest matches
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 12, 2025 - MLB

Milwaukee Brewers
6 :  0
St. Louis Cardinals

Jun 8, 2025 - MLB

St. Louis Cardinals
3 :  7
Los Angeles Dodgers

Jun 7, 2025 - MLB

St. Louis Cardinals
2 :  1
Los Angeles Dodgers

Jun 6, 2025 - MLB

St. Louis Cardinals
5 :  0
Los Angeles Dodgers

Jun 5, 2025 - MLB

St. Louis Cardinals
5 :  7
Kansas City Royals

May 31, 2025 - MLB

Texas Rangers
0 :  2
St. Louis Cardinals
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 8, 2025 - MLB

St. Louis Cardinals
3 :  7
Los Angeles Dodgers

Jun 7, 2025 - MLB

St. Louis Cardinals
2 :  1
Los Angeles Dodgers

Jun 6, 2025 - MLB

St. Louis Cardinals
5 :  0
Los Angeles Dodgers

Jun 5, 2025 - MLB

St. Louis Cardinals
5 :  7
Kansas City Royals

May 24, 2025 - MLB

St. Louis Cardinals
6 :  5
Arizona Diamondbacks

May 21, 2025 - MLB

St. Louis Cardinals
1 :  5
Detroit Tigers
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 12, 2025 - MLB

Milwaukee Brewers
6 :  0
St. Louis Cardinals

May 31, 2025 - MLB

Texas Rangers
0 :  2
St. Louis Cardinals

May 30, 2025 - MLB

Texas Rangers
11 :  1
St. Louis Cardinals

May 28, 2025 - MLB

Baltimore Orioles
4 :  6
St. Louis Cardinals

May 27, 2025 - MLB

Baltimore Orioles
4 :  7
St. Louis Cardinals

May 18, 2025 - MLB

Kansas City Royals
2 :  1
St. Louis Cardinals

Chicago White Sox against St. Louis Cardinals : Head to Head (H2H)

Chicago White Sox

50 %

St. Louis Cardinals

50 %

May 5, 2024 - MLB

St. Louis Cardinals
1 :  5
Chicago White Sox

May 3, 2024 - MLB

St. Louis Cardinals
3 :  0
Chicago White Sox

Chicago White Sox - St. Louis Cardinals Key Points

  1. The Cardinals lead the all-time series vs. the White Sox, 24-18; Chicago is 11-12 in home games.
  2. St. Louis has won seven of their last eight against teams with losing records.
  3. Chicago has lost their last 11 games vs. NL Central teams following a loss.
  4. Betting Public: Bettors are getting behind the Cardinals with 79% of moneyline tickets and 85% of the handle on St. Louis.

Our Chicago White Sox vs St. Louis Cardinals Prediction

Neither of these teams has performed well this season. Gray’s road struggles have me concerned for the Cardinals, but the lack of support from the lineup has me concerned about taking the White Sox. Bottom line—St. Louis is the better team between the two, and they should win this game, but the teams that should win don’t always do so. That being said, I’ve still got to go with the Cardinals here.

Our St. Louis vs. Chicago Pick: Cardinals ML

Prediction:

 

Cardinals -180

-180
$350 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Chicago White Sox vs St. Louis Cardinals Picks