Old Dominion Monarchs vs South Florida Bulls Prediction & Picks - NCAA Division I, FBS, Playoffs

USA - NCAA Division I, FBS, Playoffs

Old Dominion Monarchs
12/17/25 17:00
South Florida Bulls

Prediction:

 

Old Dominion ML

+140
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 by Travis Pulver in Football Picks

The Old Dominion Monarchs (Sun Belt) will face off against the South Florida Bulls (American Athletic) in the StaffDNA Cure Bowl on Wednesday, December 17, at Camping World Stadium in Orlando, FL. Kickoff for this game is scheduled for 5 p.m. EST with coverage provided by ESPN.

After finishing 9-3 in the regular season, the Monarchs will try to match their best season record as an FBS team with a win over South Florida (10-3, 2016). The plan will likely be to do just what they did during the regular season—run, run, and run some more. Old Dominion had a top ten run game during the regular season with 236.9 ypg. Along with 223.8 ypg via the passing attack, they had the No. 15 offense in the country (total yards). They weren’t too shabby on defense, too, holding opponents to 331.4 ypg (total) and less than 20 points per game. As for South Florida, they became the darlings of the media after recording upsets over two ranked teams to start the season before Miami brought them back down to earth in Week 3. Like the Monarchs, they went on to finish their regular season with a 9-3 record. However, they had a more balanced and productive offense, No. 2 in total offense with 501.7 ypg and 43 ppg (No. 2 scoring).

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Old Dominion Monarchs vs South Florida Bulls Form

Table

Teams % P W D L
50
Old Dominion Monarchs
Old Dominion Monarchs
0 0 0 0 0
55
South Florida Bulls
South Florida Bulls
0 0 0 0 0

Old Dominion Monarchs and South Florida Bulls Latest Matches

Old Dominion Monarchs
Old Dominion Monarchs Latest matches
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 29, 2025 - NCAA

Georgia State Panthers
10 :  27
Old Dominion Monarchs

Nov 22, 2025 - NCAA

Old Dominion Monarchs
45 :  10
Georgia Southern Eagles

Nov 13, 2025 - NCAA

Troy Trojans
0 :  33
Old Dominion Monarchs

Nov 1, 2025 - NCAA

Old Dominion Monarchs
31 :  6
Louisiana-Monroe Warhawks

Oct 25, 2025 - NCAA

Appalachian State Mountaineers
21 :  24
Old Dominion Monarchs

Oct 18, 2025 - NCAA

Old Dominion Monarchs
27 :  63
James Madison Dukes
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 29, 2025 - NCAA

Georgia State Panthers
10 :  27
Old Dominion Monarchs

Nov 13, 2025 - NCAA

Troy Trojans
0 :  33
Old Dominion Monarchs

Oct 25, 2025 - NCAA

Appalachian State Mountaineers
21 :  24
Old Dominion Monarchs

Oct 4, 2025 - NCAA

Coastal Carolina Chanticleers
7 :  47
Old Dominion Monarchs

Sep 27, 2025 - NCAA

Liberty Flames
7 :  21
Old Dominion Monarchs

Sep 6, 2025 - NCAA

North Carolina Central Eagles
6 :  54
Old Dominion Monarchs
L W L L W W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 22, 2025 - NCAA

Old Dominion Monarchs
45 :  10
Georgia Southern Eagles

Nov 1, 2025 - NCAA

Old Dominion Monarchs
31 :  6
Louisiana-Monroe Warhawks

Oct 18, 2025 - NCAA

Old Dominion Monarchs
27 :  63
James Madison Dukes

Oct 11, 2025 - NCAA

Old Dominion Monarchs
24 :  48
Marshall Herd

Sep 13, 2025 - NCAA

Old Dominion Monarchs
45 :  26
Virginia Tech Hokies

Aug 30, 2025 - NCAA

Old Dominion Monarchs
14 :  27
Indiana Hoosiers
South Florida Bulls
South Florida Bulls Latest matches
W L W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 29, 2025 - NCAA

Rice Owls
3 :  52
South Florida Bulls

Nov 22, 2025 - NCAA

South Florida Bulls
48 :  18
UAB Blazers

Nov 15, 2025 - NCAA

South Florida Bulls
38 :  41
Navy Midshipmen

Nov 6, 2025 - NCAA

UTSA Roadrunners
23 :  55
South Florida Bulls

Oct 25, 2025 - NCAA

South Florida Bulls
31 :  34
Memphis Tigers

Oct 18, 2025 - NCAA

Florida Atlantic Owls
13 :  48
South Florida Bulls
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 29, 2025 - NCAA

Rice Owls
3 :  52
South Florida Bulls

Nov 6, 2025 - NCAA

UTSA Roadrunners
23 :  55
South Florida Bulls

Oct 18, 2025 - NCAA

Florida Atlantic Owls
13 :  48
South Florida Bulls

Oct 3, 2025 - NCAA

Charlotte 49ers
26 :  54
South Florida Bulls

Sep 20, 2025 - NCAA

South Carolina State Bulldogs
14 :  63
South Florida Bulls

Aug 28, 2025 - NCAA

Boise State Broncos
7 :  34
South Florida Bulls
W L W L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 22, 2025 - NCAA

South Florida Bulls
48 :  18
UAB Blazers

Nov 15, 2025 - NCAA

South Florida Bulls
38 :  41
Navy Midshipmen

Oct 25, 2025 - NCAA

South Florida Bulls
31 :  34
Memphis Tigers

Oct 10, 2025 - NCAA

South Florida Bulls
63 :  36
North Texas Mean Green

Sep 13, 2025 - NCAA

South Florida Bulls
12 :  49
Miami Hurricanes

Sep 6, 2025 - NCAA

South Florida Bulls
18 :  16
Florida Gators

Old Dominion Monarchs - South Florida Bulls Key Points

  1. This will be the first time Old Dominion and South Florida have faced off in a football game.
  2. While they had identical win-loss records, Old Dominion was 7-5 ATS and South Florida was 8-3-1.
  3. The OVER was 4-8 for Old Dominion and 7-5 for South Florida.
  4. Betting Public: 93% of moneyline tickets and 81% of the handle are on South Florida.
Up to $500+ to bet on Old Dominion Monarchs - South Florida Bulls! 

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Our Old Dominion Monarchs vs South Florida Bulls Prediction

To complicate matters, we have to factor in two things for this game—neither team will have it’s starting quarterback available and USF has lost its head coach and many offensive assistants to Auburn. I’ve got more faith that Old Dominion’s Quinn Henicle (redshirt freshman) will be able to step up over South Florida’s Gaston Moore. Henicle led the Monarch’s to a 40-32 win over Arkansas State last season, running for 200+ yards in the process. Moore is a senior who has never started a game and his longest pass this season went for 13 yards.

Old Dominion has a better chance of overcoming the loss of its QB1 than South Florida. That gives Monarch’s ML a lot of value.

Our StaffDNA Cure Bowl Pick: Old Dominion ML

Prediction:

 

Old Dominion ML

+140
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Old Dominion Monarchs vs South Florida Bulls Picks