South Carolina Gamecocks vs Missouri Tigers Prediction & Picks - NCAA

USA - NCAA

South Carolina Gamecocks
9/20/25 19:00
Missouri Tigers

Prediction:

 

Missouri Tigers -9.5 Alternate Spread

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 by Matt Lowrimore in NCAA Picks

The Saturday Week 4 slate in college football will feature a ton of exciting games, including an SEC matchup between the South Carolina Gamecocks and the 23rd-ranked Missouri Tigers. Let’s take a look at the match statistics and predictions for this game between the Gamecocks and Tigers.

South Carolina enters this game with a record of 2-1 and 0-1 in the SEC. The Gamecocks most recently lost to the Vanderbilt Commodores in Week 3 by a score of 31-7. South Carolina’s offense had a total of 328 yards, while its defense allowed 323 yards. Backup quarterback Luke Doty came in for injured quarterback LaNorris Sellors and threw for 148 yards and one interception, while running back Rahsul Faison led the team in rushing with 74 yards and one touchdown.

As for Missouri, they enter this game with a record of 3-0, and this will be their first game in the SEC this season. The Tigers most recently beat the Louisiana Ragin’ Cajuns in Week 3 by a score of 52-10. Missouri’s offense had a total of 606 yards, while its defense allowed 121 yards. Quarterback Beau Pribula threw for 174 yards, two touchdowns, and one interception, while running back Ahmad Hardy led the team in rushing with 250 yards and three touchdowns.

South Carolina Gamecocks vs Missouri Tigers Form

Table

Teams % P W D L
9
Missouri Tigers
Missouri Tigers
0 0 0 0 0
13
South Carolina Gamecocks
South Carolina Gamecocks
0 1 0 0 1

South Carolina Gamecocks and Missouri Tigers Latest Matches

South Carolina Gamecocks
South Carolina Gamecocks Latest matches
W W L W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 13, 2025 - NCAA

Vanderbilt Commodores
31 :  7
South Carolina Gamecocks

Sep 6, 2025 - NCAA

South Carolina State Bulldogs
10 :  38
South Carolina Gamecocks

Aug 31, 2025 - NCAA

Virginia Tech Hokies
11 :  24
South Carolina Gamecocks

Dec 31, 2024 - NCAA Division I, FBS, Playoffs

South Carolina Gamecocks
17 :  21
Illinois Fighting Illini

Nov 30, 2024 - NCAA

South Carolina Gamecocks
17 :  14
Clemson Tigers

Nov 23, 2024 - NCAA

Wofford Terriers
12 :  56
South Carolina Gamecocks
W W W W W L
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 13, 2025 - NCAA

Vanderbilt Commodores
31 :  7
South Carolina Gamecocks

Sep 6, 2025 - NCAA

South Carolina State Bulldogs
10 :  38
South Carolina Gamecocks

Aug 31, 2025 - NCAA

Virginia Tech Hokies
11 :  24
South Carolina Gamecocks

Nov 23, 2024 - NCAA

Wofford Terriers
12 :  56
South Carolina Gamecocks

Nov 16, 2024 - NCAA

Missouri Tigers
30 :  34
South Carolina Gamecocks

Nov 2, 2024 - NCAA

Texas A&M Aggies
20 :  44
South Carolina Gamecocks
L W W W L
Victories

3/5 (60%)

Draw

0/5 (0%)

Defeats

2/5 (40%)

Dec 31, 2024 - NCAA Division I, FBS, Playoffs

South Carolina Gamecocks
17 :  21
Illinois Fighting Illini

Nov 30, 2024 - NCAA

South Carolina Gamecocks
17 :  14
Clemson Tigers

Nov 9, 2024 - NCAA

South Carolina Gamecocks
28 :  7
Vanderbilt Commodores

Oct 19, 2024 - NCAA

South Carolina Gamecocks
35 :  9
Oklahoma Sooners

Oct 12, 2024 - NCAA

South Carolina Gamecocks
25 :  27
Alabama Crimson Tide
Missouri Tigers
Missouri Tigers Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Sep 13, 2025 - NCAA

Louisiana-Lafayette Ragin Cajuns
10 :  52
Missouri Tigers

Sep 6, 2025 - NCAA

Kansas Jayhawks
31 :  42
Missouri Tigers

Aug 28, 2025 - NCAA

Central Arkansas Bears
6 :  61
Missouri Tigers

Dec 30, 2024 - NCAA Division I, FBS, Playoffs

Iowa Hawkeyes
24 :  27
Missouri Tigers

Nov 30, 2024 - NCAA

Arkansas Razorbacks
21 :  28
Missouri Tigers

Nov 23, 2024 - NCAA

Missouri Tigers
39 :  20
Mississippi State Bulldogs
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Sep 13, 2025 - NCAA

Louisiana-Lafayette Ragin Cajuns
10 :  52
Missouri Tigers

Sep 6, 2025 - NCAA

Kansas Jayhawks
31 :  42
Missouri Tigers

Aug 28, 2025 - NCAA

Central Arkansas Bears
6 :  61
Missouri Tigers

Dec 30, 2024 - NCAA Division I, FBS, Playoffs

Iowa Hawkeyes
24 :  27
Missouri Tigers

Nov 30, 2024 - NCAA

Arkansas Razorbacks
21 :  28
Missouri Tigers

Nov 9, 2024 - NCAA

Oklahoma Sooners
23 :  30
Missouri Tigers
L W L L W
Victories

2/5 (40%)

Draw

0/5 (0%)

Defeats

3/5 (60%)

Nov 23, 2024 - NCAA

Missouri Tigers
39 :  20
Mississippi State Bulldogs

Nov 16, 2024 - NCAA

Missouri Tigers
30 :  34
South Carolina Gamecocks

Oct 26, 2024 - NCAA

Missouri Tigers
0 :  34
Alabama Crimson Tide

Oct 12, 2024 - NCAA

Missouri Tigers
45 :  3
UMass Minutemen

Oct 5, 2024 - NCAA

Missouri Tigers
10 :  41
Texas A&M Aggies

South Carolina Gamecocks against Missouri Tigers : Head to Head (H2H)

Nov 16, 2024 - NCAA

Missouri Tigers
30 :  34
South Carolina Gamecocks

South Carolina Gamecocks - Missouri Tigers Key Points

  1. Missouri is 3-0 ATS this season
  2. Missouri is averaging 51.7 points per game this season
  3. Missouri is allowing 15.7 points per game this season
  4. South Carolina’s LaNorris Sellors is questionable for this game

Our South Carolina Gamecocks vs Missouri Tigers Prediction

While Missouri has mostly played lower-level competition this season, they have still been one of the most impressive teams in the country. More specifically, their offense is averaging 51.7 points per game. Their defense has also allowed just 15.7 points per game, with the one blip against Kansas, where they allowed 31 points.

Further, the Tigers’ rushing offense has been lethal, averaging 302.3 points per game, while they are also averaging 284.7 passing yards per game. The biggest question mark in this game is the status of South Carolina quarterback LaNorris Sellors. Right now, he is status is uncertain, but even if he does play, Missouri is too balanced a team to let him beat them. For that reason, our South Carolina Gamecocks vs Missouri Tigers prediction is: Missouri Tigers -9.5 Alternate Spread.

Prediction:

 

Missouri Tigers -9.5 Alternate Spread

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South Carolina Gamecocks vs Missouri Tigers Picks