Jannik Sinner vs Alexei Popyrin Prediction & Picks - ATP Italian Open

ATP - ATP Italian Open

ATP 1 Italy
Jannik Sinner
5/11/26 09:50
ATP 100 Australia
Alexei Popyrin

Prediction:

 

Alexei Popyrin +6.5 Games

-125
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 by Lou Aguila | in ATP Italian Open Picks

Jannik Sinner is on the hunt for a third ATP 1000 title on clay this year after ruling the tournaments in Monte Carlo and Madrid. The Italian made quick work of Sebastian Ofner 6-3, 6-4 to claim his 12th win on the dirt since the start of the clay-court swing.

After crashing out in the first round in Monte Carlo and Madrid, Alexei Popyrin has picked up two wins in Rome to reach the third round. Popyrin toppled Matteo Berrettini 6-2, 6-3 in the opening round before hacking out a three-set win over Jakub Mensik 6-3, 2-6, 6-4 in the second round.

The Matchup:

Sinner will march into the third round of his home tournament as a massive favorite with Caesars Sportsbook posting him at -10,000 moneyline. Sinner, who has bumped up his win percentage on clay to 71 percent after going 12-0 on the surface this year, sits at -115 to cover -6.5 games against Popyrin.

Popyrin defeated Sinner in straight sets five years ago at the 2021 Madrid Open. The Australian would go on to lose the next head-to-head matchups against the Italian, losing to him in three sets at the 2025 US Open and absorbing another sweep in Doha earlier this year. To level the playing field, Popyrin will have a +6.5-game advantage over Sinner in their fourth career match.

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Jannik Sinner vs Alexei Popyrin Form

Jannik Sinner and Alexei Popyrin Latest Matches

Jannik Sinner Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 9, 2026 - ATP Italian Open

Jannik Sinner
2 :  0
Sebastian Ofner

May 3, 2026 - ATP Mutua Madrid Open

Jannik Sinner
2 :  0
Alexander Zverev

May 1, 2026 - ATP Mutua Madrid Open

Jannik Sinner
2 :  0
Arthur Fils

Apr 29, 2026 - ATP Mutua Madrid Open

Jannik Sinner
2 :  0
Rafael Jodar

Apr 28, 2026 - ATP Mutua Madrid Open

Jannik Sinner
2 :  0
Cameron Norrie

Apr 26, 2026 - ATP Mutua Madrid Open

Jannik Sinner
2 :  0
Elmer Moller
Alexei Popyrin Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 9, 2026 - ATP Italian Open

Alexei Popyrin
2 :  1
Jakub Mensik

May 7, 2026 - ATP Italian Open

Alexei Popyrin
2 :  0
Matteo Berrettini

Apr 23, 2026 - ATP Mutua Madrid Open

Alexei Popyrin
0 :  2
Martin Damm Jr

Apr 7, 2026 - ATP Monte Carlo Masters

Alexei Popyrin
0 :  2
Casper Ruud

Apr 3, 2026 - ATP Houston

Alexei Popyrin
1 :  2
Frances Tiafoe

Apr 2, 2026 - ATP Houston

Alex Michelsen
1 :  2
Alexei Popyrin

Jannik Sinner against Alexei Popyrin : Head to Head (H2H)

Jannik Sinner

100 %

Alexei Popyrin

0 %

Feb 18, 2026 - ATP Qatar Open

Alexei Popyrin
0 :  2
Jannik Sinner

Aug 28, 2025 - ATP US Open

Jannik Sinner
3 :  0
Alexei Popyrin

Jannik Sinner - Alexei Popyrin Key Points

  1. Jannik Sinner is 12-0 on clay in 2026.
  2. Jannik Sinner won the 2026 Monte Carlo and Madrid Masters.
  3. Alexei Popyrin defeated Jannik at the 2021 Madrid Masters.
  4. Alexei Popyrin is 0-3 vs. top-1 players
Up to $250 to bet on Jannik Sinner - Alexei Popyrin! 

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Our Jannik Sinner vs Alexei Popyrin Prediction

Jannik Sinner will move on to the fourth round of the Italian Open with another straightforward win over Alexei Popyrin. However, Popyrin’s strong play recently, which saw him claim over Berrettini and Mensik in this tournament, makes him an intriguing option on the spread line, where he struts a +6.5-game advantage.

Sinner has been unplayable over the past three months, but the slow courts of Rome could prevent him from reaching the level of dominance he had in Madrid, where his God-tier ball-striking was simply unstoppable.

Popyrin may have a slim chance of pulling off an upset here, but it appears he has unlocked a higher level of tennis in his two previous wins to keep him competitive against Sinner. Moreover, the court conditions in this tournament will allow him to stand toe-to-toe with Sinner in rallies since the balls coming from the Italian would not feel as heavy as they did on hard courts, or even on the red dirt of Madrid.

Our betting prediction for Jannik Sinner vs. Alexei Popyrin: Alexei Popyrin +6.5 Games

Prediction:

 

Alexei Popyrin +6.5 Games

-125
$250 offered for betting!

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Jannik Sinner vs Alexei Popyrin Picks