San Francisco 49ers vs Seattle Seahawks Prediction & Picks - NFL

USA - NFL

San Francisco 49ers
1/3/26 20:00
Seattle Seahawks

Prediction:

 

San Francisco 49ers +1.5

-108
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 by Matt Lowrimore | in NFL Picks

Week 18 of the NFL will feature two Saturday games, one of which will see the San Francisco 49ers take on the Seattle Seahawks. Let’s take a look at the match statistics and predictions for this game between the 49ers and the Seahawks.

Seattle enters this game with a record of 13-3, having most recently beaten the Carolina Panthers in Week 17 by a score of 27-10. The Seahawks’ offense had a total of 288 yards, while its defense allowed 139 yards. Quarterback Sam Darnold threw for 147 yards, one touchdown, and one interception, while running back Zach Charbonnet led the team in rushing with 110 yards and two touchdowns.

As for San Francisco, they enter this game with a record of 12-4, having most recently beaten the Chicago Bears in Week 17 by a score of 42-38. The 49ers’ offense had a total of 496 yards, while its defense allowed 440 yards. Quarterback Brock Purdy threw for 303 yards, three touchdowns, and one interception, while running back Christian McCaffrey led the team in rushing with 140 yards and one touchdown.

San Francisco 49ers vs Seattle Seahawks Form

Table

Teams Pts P W L
1 Seattle Seahawks
0.824 17 14 3
7 San Francisco 49ers
0.706 17 12 5

San Francisco 49ers and Seattle Seahawks Latest Matches

San Francisco 49ers
San Francisco 49ers Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Dec 28, 2025 - NFL

San Francisco 49ers
42 :  38
Chicago Bears

Dec 22, 2025 - NFL

Indianapolis Colts
27 :  48
San Francisco 49ers

Dec 14, 2025 - NFL

San Francisco 49ers
37 :  24
Tennessee Titans

Nov 30, 2025 - NFL

Cleveland Browns
8 :  26
San Francisco 49ers

Nov 24, 2025 - NFL

San Francisco 49ers
20 :  9
Carolina Panthers

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 28, 2025 - NFL

San Francisco 49ers
42 :  38
Chicago Bears

Dec 14, 2025 - NFL

San Francisco 49ers
37 :  24
Tennessee Titans

Nov 24, 2025 - NFL

San Francisco 49ers
20 :  9
Carolina Panthers

Nov 9, 2025 - NFL

San Francisco 49ers
26 :  42
Los Angeles Rams

Oct 19, 2025 - NFL

San Francisco 49ers
20 :  10
Atlanta Falcons

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 22, 2025 - NFL

Indianapolis Colts
27 :  48
San Francisco 49ers

Nov 30, 2025 - NFL

Cleveland Browns
8 :  26
San Francisco 49ers

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Nov 2, 2025 - NFL

New York Giants
24 :  34
San Francisco 49ers

Oct 26, 2025 - NFL

Houston Texans
26 :  15
San Francisco 49ers

Oct 12, 2025 - NFL

Tampa Bay Buccaneers
30 :  19
San Francisco 49ers
Seattle Seahawks
Seattle Seahawks Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Dec 28, 2025 - NFL

Carolina Panthers
10 :  27
Seattle Seahawks

Dec 18, 2025 - NFL

Seattle Seahawks
38 :  37
Los Angeles Rams

Dec 14, 2025 - NFL

Seattle Seahawks
18 :  16
Indianapolis Colts

Dec 7, 2025 - NFL

Atlanta Falcons
9 :  37
Seattle Seahawks

Nov 30, 2025 - NFL

Seattle Seahawks
26 :  0
Minnesota Vikings

Nov 23, 2025 - NFL

Tennessee Titans
24 :  30
Seattle Seahawks
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Dec 18, 2025 - NFL

Seattle Seahawks
38 :  37
Los Angeles Rams

Dec 14, 2025 - NFL

Seattle Seahawks
18 :  16
Indianapolis Colts

Nov 30, 2025 - NFL

Seattle Seahawks
26 :  0
Minnesota Vikings

Nov 9, 2025 - NFL

Seattle Seahawks
44 :  22
Arizona Cardinals

Oct 20, 2025 - NFL

Seattle Seahawks
27 :  19
Houston Texans

Oct 5, 2025 - NFL

Seattle Seahawks
35 :  38
Tampa Bay Buccaneers
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Dec 28, 2025 - NFL

Carolina Panthers
10 :  27
Seattle Seahawks

Dec 7, 2025 - NFL

Atlanta Falcons
9 :  37
Seattle Seahawks

Nov 23, 2025 - NFL

Tennessee Titans
24 :  30
Seattle Seahawks

Nov 16, 2025 - NFL

Los Angeles Rams
21 :  19
Seattle Seahawks

Nov 2, 2025 - NFL

Washington Commanders
14 :  38
Seattle Seahawks

Oct 12, 2025 - NFL

Jacksonville Jaguars
12 :  20
Seattle Seahawks

San Francisco 49ers against Seattle Seahawks : Head to Head (H2H)

San Francisco 49ers

80 %

Seattle Seahawks

20 %

Sep 7, 2025 - NFL

Seattle Seahawks
13 :  17
San Francisco 49ers

Nov 17, 2024 - NFL

San Francisco 49ers
17 :  20
Seattle Seahawks

Oct 10, 2024 - NFL

Seattle Seahawks
24 :  36
San Francisco 49ers

Nov 23, 2023 - NFL

Seattle Seahawks
13 :  31
San Francisco 49ers

Jan 14, 2023 - NFL

San Francisco 49ers
41 :  23
Seattle Seahawks

San Francisco 49ers - Seattle Seahawks Key Points

  1. Seattle is 7-1 SU on the road
  2. Seattle is 6-0 SU in their last 6 games
  3. San Francisco is 5-2 SU at home
  4. San Francisco is 6-0 SU in their last 6 games

Our San Francisco 49ers vs Seattle Seahawks Prediction

The Seahawks are the small road favorites; however, the 49ers look to be the best betting option. This game has a lot at stake as the winner will also win the NFC West division and earn the number one seed in the NFC playoffs. 

The 49ers have already beaten the Seahawks this season, albeit all the way back in Week 1. Both teams are also on a tear, having won their last six games in a row. That being said, the 49ers seemingly have the X-factor in this matchup with Christian McCaffrey. He has been the focal point for this offense and has proven he can do just about everything.

Even though the Seahawks have only lost one road game this season, our San Francisco 49ers vs Seattle Seahawks prediction is: San Francisco 49ers +1.5.

Prediction:

 

San Francisco 49ers +1.5

-108
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

San Francisco 49ers vs Seattle Seahawks Picks