St. Louis Cardinals vs Seattle Mariners Prediction & Picks - MLB

USA - MLB

St. Louis Cardinals
4/26/26 14:15
Seattle Mariners

Prediction:

 

The Mariners -1.5 Runs

+118
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 by Lou Aguila | in MLB Picks

The Seattle Mariners eye a convincing sweep of the St. Louis Cardinals in Game 3 of their interleague series on Sunday.

Current Form:

Listed as -140 road favorites for Game 3, the Seattle Mariners have won their last three games, including back-to-back wins over the St. Louis Cardinals in this three-game interleague series. Seattle is batting .313 with 5.0 runs per game over their last five games.

Right-handed pitcher Emerson Hancock will be starting on Sunday. Hancock (2-1, 2.83 ERA) gave up three earned runs and seven hits in a 4-6 loss to the Athletics on April 20.

The Cardinals, listed at +118 at home, dropped to 14-12 after their third consecutive loss and fourth of their last five games. Over their last five games, St. Louis’ starters have posted a 6.65 ERA while the bullpen is throwing a 4.49 ERA.

Projected starter Michael McGreevy (1-2, 3.29 ERA) is coming off a lousy start against Miami, giving up four earned runs over 5.2 innings in a 3-5 loss on April 20.

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St. Louis Cardinals vs Seattle Mariners Form

Table

Teams Pts P W L
11 St. Louis Cardinals
0.525 80 42 38
13 Seattle Mariners
0.5 84 42 42

St. Louis Cardinals and Seattle Mariners Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 25, 2026 - MLB

St. Louis Cardinals
9 :  11
Seattle Mariners

Apr 24, 2026 - MLB

St. Louis Cardinals
2 :  3
Seattle Mariners

Apr 22, 2026 - MLB

Miami Marlins
4 :  1
St. Louis Cardinals

Apr 21, 2026 - MLB

Miami Marlins
3 :  5
St. Louis Cardinals

Apr 20, 2026 - MLB

Miami Marlins
5 :  3
St. Louis Cardinals

Apr 19, 2026 - MLB

Houston Astros
5 :  7
St. Louis Cardinals
L L W W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 25, 2026 - MLB

St. Louis Cardinals
9 :  11
Seattle Mariners

Apr 24, 2026 - MLB

St. Louis Cardinals
2 :  3
Seattle Mariners

Apr 15, 2026 - MLB

St. Louis Cardinals
5 :  3
Cleveland Guardians

Apr 14, 2026 - MLB

St. Louis Cardinals
6 :  5
Cleveland Guardians

Apr 13, 2026 - MLB

St. Louis Cardinals
3 :  9
Cleveland Guardians

Apr 12, 2026 - MLB

St. Louis Cardinals
3 :  9
Boston Red Sox
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 22, 2026 - MLB

Miami Marlins
4 :  1
St. Louis Cardinals

Apr 21, 2026 - MLB

Miami Marlins
3 :  5
St. Louis Cardinals

Apr 20, 2026 - MLB

Miami Marlins
5 :  3
St. Louis Cardinals

Apr 19, 2026 - MLB

Houston Astros
5 :  7
St. Louis Cardinals

Apr 18, 2026 - MLB

Houston Astros
5 :  7
St. Louis Cardinals

Apr 17, 2026 - MLB

Houston Astros
4 :  9
St. Louis Cardinals
Seattle Mariners
Seattle Mariners Latest matches
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 25, 2026 - MLB

St. Louis Cardinals
9 :  11
Seattle Mariners

Apr 24, 2026 - MLB

St. Louis Cardinals
2 :  3
Seattle Mariners

Apr 22, 2026 - MLB

Seattle Mariners
5 :  4
Athletics

Apr 21, 2026 - MLB

Seattle Mariners
2 :  5
Athletics

Apr 20, 2026 - MLB

Seattle Mariners
4 :  6
Athletics

Apr 19, 2026 - MLB

Seattle Mariners
5 :  2
Texas Rangers
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 22, 2026 - MLB

Seattle Mariners
5 :  4
Athletics

Apr 21, 2026 - MLB

Seattle Mariners
2 :  5
Athletics

Apr 20, 2026 - MLB

Seattle Mariners
4 :  6
Athletics

Apr 19, 2026 - MLB

Seattle Mariners
5 :  2
Texas Rangers

Apr 18, 2026 - MLB

Seattle Mariners
7 :  3
Texas Rangers

Apr 17, 2026 - MLB

Seattle Mariners
0 :  5
Texas Rangers
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 25, 2026 - MLB

St. Louis Cardinals
9 :  11
Seattle Mariners

Apr 24, 2026 - MLB

St. Louis Cardinals
2 :  3
Seattle Mariners

Apr 16, 2026 - MLB

San Diego Padres
5 :  2
Seattle Mariners

Apr 15, 2026 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Apr 14, 2026 - MLB

San Diego Padres
4 :  1
Seattle Mariners

Apr 8, 2026 - MLB

Texas Rangers
3 :  0
Seattle Mariners

St. Louis Cardinals against Seattle Mariners : Head to Head (H2H)

St. Louis Cardinals

0 %

Seattle Mariners

100 %

Apr 25, 2026 - MLB

St. Louis Cardinals
9 :  11
Seattle Mariners

Apr 24, 2026 - MLB

St. Louis Cardinals
2 :  3
Seattle Mariners

Sep 10, 2025 - MLB

Seattle Mariners
4 :  2
St. Louis Cardinals

Sep 9, 2025 - MLB

Seattle Mariners
5 :  3
St. Louis Cardinals

Sep 8, 2025 - MLB

Seattle Mariners
4 :  2
St. Louis Cardinals

Sep 8, 2024 - MLB

St. Louis Cardinals
4 :  10
Seattle Mariners

St. Louis Cardinals - Seattle Mariners Key Points

  1. Seattle is 5-2 SU in its last 7 games.
  2. Seattle is 6-0 SU in its last 6 games against St. Louis.
  3. St. Louis is 2-5 SU in its last 7 games when playing at home against Seattle.
  4. St. Louis is 1-4 SU in its last 5 games.
Up to $250 to bet on St. Louis Cardinals - Seattle Mariners! 

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Our St. Louis Cardinals vs Seattle Mariners Prediction

Fearless Forecast: The Mariners sweep the Cardinals 7-4

The Edge: Seattle has won its last six meetings against St. Louis. The Mariners are 2-8 in their last 10 road games, but against the Cardinals, they sport a 4-1 record in St. Louis. Don’t expect much from Emerson Hancock, who has been shaky on the mound this season. The Cardinals will win this finale with their big bats that produce at least five runs over their last five assignments.

The Bet: The Mariners won by at least two runs in five of their last six wins over the Cardinals. St. Louis starter Michael McGreavy surrendered one earned run over six innings in his first and only start against the Mariners on September 10. However, regardless of McGreavy’s showing, the Cardinals will keep losing ballgames as long as their bullpen (5.23 ERA) continues to give up leads during the late innings.

Our betting prediction for the Seattle Mariners vs. the St. Louis Cardinals: The Mariners -1.5 runs

Prediction:

 

The Mariners -1.5 Runs

+118
$250 offered for betting!

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St. Louis Cardinals vs Seattle Mariners Picks