San Diego Padres vs Seattle Mariners Prediction & Picks - MLB

USA - MLB

San Diego Padres
4/16/26 20:40
Seattle Mariners

Prediction:

 

OVER 8.5

-110
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 by Travis Pulver | in MLB Picks

The Padres (12-6, 8-4 Home) will go for the series sweep tonight when they host the Seattle Mariners (8-11, 1-7 Away) at 8:40 p.m. EST at Petco Park in San Diego, CA, with coverage on MLB.TV.

San Diego has been on a roll, and with a win tonight, the Padres can complete their first homestand sweep of the season and extend their winning streak to eight games. It started with an 8-2 win over the Pirates in Pittsburgh, continued at home with a four-game sweep of the Rockies, and continued with a 4-1 win over the Mariners on Tuesday and a 7-6 victory yesterday.

Walker Buehler is scheduled to get the start for San Diego tonight. Buehler struggled in his first two outings of the season, giving up five hits and three runs in four innings vs. the Giants and getting tagged for four runs in 2 2/3 innings vs. the Red Sox. But he was solid in his last outing vs. the Rockies (six innings, three hits, 0 runs).

Seattle is expected to go with Luis Castillo. Unlike Buehler, he had his best start of the season, his first time out, vs. the Yankees (six innings, three hits, 0 runs), but has struggled since. He gave up six hits and three earned runs vs. the Angels and tagged for seven in 3 1/3 vs. the Astros.

San Diego Padres vs Seattle Mariners Form

Table

Teams Pts P W L
8 San Diego Padres
0.531 81 43 38
13 Seattle Mariners
0.5 84 42 42

San Diego Padres and Seattle Mariners Latest Matches

San Diego Padres
San Diego Padres Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 15, 2026 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Apr 14, 2026 - MLB

San Diego Padres
4 :  1
Seattle Mariners

Apr 12, 2026 - MLB

San Diego Padres
7 :  2
Colorado Rockies

Apr 11, 2026 - MLB

San Diego Padres
9 :  5
Colorado Rockies

Apr 10, 2026 - MLB

San Diego Padres
5 :  2
Colorado Rockies

Apr 9, 2026 - MLB

San Diego Padres
7 :  3
Colorado Rockies
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 15, 2026 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Apr 14, 2026 - MLB

San Diego Padres
4 :  1
Seattle Mariners

Apr 12, 2026 - MLB

San Diego Padres
7 :  2
Colorado Rockies

Apr 11, 2026 - MLB

San Diego Padres
9 :  5
Colorado Rockies

Apr 10, 2026 - MLB

San Diego Padres
5 :  2
Colorado Rockies

Apr 9, 2026 - MLB

San Diego Padres
7 :  3
Colorado Rockies
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 8, 2026 - MLB

Pittsburgh Pirates
2 :  8
San Diego Padres

Apr 7, 2026 - MLB

Pittsburgh Pirates
7 :  1
San Diego Padres

Apr 6, 2026 - MLB

Pittsburgh Pirates
0 :  5
San Diego Padres

Apr 5, 2026 - MLB

Boston Red Sox
6 :  8
San Diego Padres

Apr 4, 2026 - MLB

Boston Red Sox
2 :  3
San Diego Padres

Apr 3, 2026 - MLB

Boston Red Sox
5 :  2
San Diego Padres
Seattle Mariners
Seattle Mariners Latest matches
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 15, 2026 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Apr 14, 2026 - MLB

San Diego Padres
4 :  1
Seattle Mariners

Apr 13, 2026 - MLB

Seattle Mariners
6 :  2
Houston Astros

Apr 12, 2026 - MLB

Seattle Mariners
6 :  1
Houston Astros

Apr 11, 2026 - MLB

Seattle Mariners
8 :  7
Houston Astros

Apr 10, 2026 - MLB

Seattle Mariners
9 :  6
Houston Astros
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 13, 2026 - MLB

Seattle Mariners
6 :  2
Houston Astros

Apr 12, 2026 - MLB

Seattle Mariners
6 :  1
Houston Astros

Apr 11, 2026 - MLB

Seattle Mariners
8 :  7
Houston Astros

Apr 10, 2026 - MLB

Seattle Mariners
9 :  6
Houston Astros

Apr 1, 2026 - MLB

Seattle Mariners
3 :  5
New York Yankees

Mar 31, 2026 - MLB

Seattle Mariners
0 :  5
New York Yankees
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Apr 15, 2026 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Apr 14, 2026 - MLB

San Diego Padres
4 :  1
Seattle Mariners

Apr 8, 2026 - MLB

Texas Rangers
3 :  0
Seattle Mariners

Apr 7, 2026 - MLB

Texas Rangers
3 :  2
Seattle Mariners

Apr 6, 2026 - MLB

Texas Rangers
2 :  1
Seattle Mariners

Apr 5, 2026 - MLB

Los Angeles Angels
8 :  7
Seattle Mariners

San Diego Padres against Seattle Mariners : Head to Head (H2H)

San Diego Padres

100 %

Seattle Mariners

0 %

Apr 15, 2026 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Apr 14, 2026 - MLB

San Diego Padres
4 :  1
Seattle Mariners

Mar 23, 2026 - MLB Spring Training

San Diego Padres
10 :  3
Seattle Mariners

Mar 17, 2026 - MLB Spring Training

Seattle Mariners
6 :  9
San Diego Padres

Mar 5, 2026 - MLB Spring Training

Seattle Mariners
6 :  27
San Diego Padres

Feb 28, 2026 - MLB Spring Training

San Diego Padres
7 :  1
Seattle Mariners

San Diego Padres - Seattle Mariners Key Points

  1. Seattle leads the all-time series vs. San Diego, 73-66.
  2. While undefeated so far this season vs. the Mariners, the Padres went 4-14 vs. San Diego in the last four seasons.
  3. The OVER is 7-3 for San Diego over the last ten games and 5-5 for Seattle.
  4. Betting Public: 79% of total tickets and 82% of the handle are on the over.

Our San Diego Padres vs Seattle Mariners Prediction

Seattle has been hitting the ball well of late and scoring runs, but their stats may be a bit inflated after facing a Houston team that is struggling with its pitching and defense. Yes, they got six runs yesterday, but they were held to one the day before and to three total in three games vs. Texas. As for San Diego, the Padres have hit .299 over the last week and averaged 6+ runs a game. I expect San Diego to win, but since neither starting pitcher is impressive, I’m going with the OVER.

Our Seattle vs. San Diego Pick: OVER 8.5

Prediction:

 

OVER 8.5

-110
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San Diego Padres vs Seattle Mariners Picks