San Diego Padres vs Seattle Mariners Prediction & Picks - MLB

Prediction published on 4/15/26, 6:10 PM  by Lou Aguila | Modified on 4/17/26 at 1:30 PM in MLB Picks

With the total set at a modest 8 runs, the Under is once again drawing a lot of interest in the market as two dominant starters square off in Game 2 of the series between the San Diego Padres and the Seattle Mariners.

Momentum: The San Diego Padres (11-6) have won their last six games and 10 of their last 12 to keep them within two games of their NL West rivals, the LA Dodgers (13-4). After completing a four-game sweep of the Colorado Rockies, the Padres drew first blood in the series against the Seattle Mariners, taking Game 1, 4-1, behind a stellar start from Michael King, who surrendered one earned run over 6.0 innings.

Meanwhile, Tuesday’s result snapped the Mariners’ four-game winning streak. Seattle had swept all four games against the Houston Astros to address their sagging record.

Matchup: The Padres took Game 1 of their first and only series with the Mariners this season. San Diego has now won 2 of their last three meetings with Seattle, but the Mariners are 7-3 in their last 10 matches with the Padres.

Mariners RHP Emerson Hancock (2-1, 2.04 ERA) will take on Padres RHP Randy Vasquez (1-0, 1.02 ERA)

Hot on Board: The Padres and the Mariners are both listed at -110 on the moneyline, with San Diego offering +180 if they win by two runs. The total is pegged at over/under 8 runs.