Minnesota Twins vs Seattle Mariners Prediction & Picks - MLB

Prediction published on 4/28/26, 4:10 PM  by Lou Aguila | Modified on 4/30/26 at 3:05 PM in MLB Picks

The Minnesota Twins, who scored a total of 21 runs in the last two games against the Seattle Mariners, enter Tuesday’s Game 2 as intriguing +110 underdogs.

Momentum: The Seattle Mariners’ four-game winning streak ended following a 4-11 loss to Minnesota on Monday. On the other hand, the result snapped the Twins’ five-game slide. The Mariners sit third in the AL West with a 14-16 record, while the Twins are also in third at 13-16.

The Matchup: The Twins have won the last three head-to-heads with the Mariners and managed to score 10 or more runs in the last two meetings.

Starting Pitchers: Mariners RHP Logan Gilbert (1-3, 4.35 ERA) vs. Twins RHP Joe Ryan (2-2, 3.90 ERA).

Twins’ hurler Joe Ryan has surrendered one earned run and struck out 18 batters over 11.2 innings across his last two starts against the Mariners. Ryan threw four earned runs over seven innings in the Twins’ 8-10 loss to the New York Mets on April 23, but he was outstanding in the three starts before the last one.

Mariners Logan Gilbert avoided a loss in his last start after throwing three earned runs over four innings in a 5-4 win over the Athletics. It took Gilbert almost two years to get a chance to pitch against the Twins again. The last time he faced Minnesota, he gave up two earned runs over six innings to help the Mariners bag a 3-2 win.