Houston Astros vs Seattle Mariners Prediction & Picks - MLB

Prediction published on 5/12/26, 4:48 PM  by Carlos Zabala | Modified on 5/12/26 at 11:35 PM in MLB Picks

The Mariners, with a 20-22 record, were favored to lead the AL West in preseason betting odds, but now it looks like they won't have it so easy. The Astros, with a 16-26 record, meanwhile, look unrecognizable at the bottom of the division. They played each other on Tuesday at Daikin Park, and Seattle won 3-1.

Julio Rodríguez hit a towering home run of over 400 feet; Arozarena added a pair of hits. Meanwhile, Cal Raleigh is a concern, going 0-for-4. The catcher, who finished second in the MVP voting, is in a terrible slump, going 0-for-36 since April 27, and his no-hitter is the longest in all of MLB.

Bryan Woo, who has been less dominant than last season and has a 4.02 ERA, will start Wednesday's game. Tatsuya Imai will start for the Astros. He has a 7.27 ERA. Due to "arm fatigue," he made a rehab start in the minor leagues. He returned to the rotation but will likely throw a pitch limit on Tuesday.