Cincinnati Reds vs Seattle Mariners Prediction & Picks - MLB

Prediction published on 4/15/25, 3:11 PM  by Carlos Zabala | Modified on 2/11/26 at 8:40 AM in MLB Picks

Two teams, the Mariners and Reds, with playoff hopes for the 2025 season, are meeting in 2025. After the first three weeks of MLB action, both have an 8-8 record, so it's too early to determine what will happen to them in the coming months.

However, what is certain is that both teams have formidable starting pitching rotations, especially the Mariners', with a solid group of five starters from first through fifth. A pitcher who left the Reds and is now a Mariner will face his former team on Tuesday: Luis Castillo. When Castillo left the team, the Reds planted the seeds for their starting rotation for the coming years with Greene and Lodolo, who have had excellent starts this season that have Reds fans excited.

Lodolo will pitch for the Reds at the Great American Ball Park on Tuesday, continuing his furious start with a 0.96 ERA, the third-best in the NL, and the fourth is teammate Greene with a 0.98 ERA.

It's expected to be a low-run game, even though the Game Total line is set at 8.5 by the bookmakers, as the Mariners bullpen has also responded strongly in 2025, especially Muñoz with six saves in six attempts.