Chicago Cubs vs Seattle Mariners Prediction & Picks - MLB

Prediction published on 6/21/25, 10:57 AM  by Travis Pulver | Modified on 1/13/26 at 9:37 AM in MLB Picks

The Cubs will look to get back on the right side of the scoreboard today when they face the Seattle Mariners in the second game of their weekend series. Seattle won Friday’s game 9-4 after getting two home runs from Cal Raleigh and Mitch Garver. Fans can follow the action today once the game gets underway at Kyle Field at 2:20 p.m. EST.

Chicago is having a solid year, going 45-30 to date (24-14 at home, 21-16 on the road). They are second in runs scored with 401 (Dodgers, 426), but their eighth when it comes to scoring at home (185). The pitching staff ranks tenth with a 3.69 ERA (starters—3.93, relievers—3.38). They’ll give Cade Horton the ball to start the day. Horton has gone 3-1 in seven starts with a 3.47 ERA and 1.21 WHIP. Seattle has been competitive in the AL West at 38-36, going 20-19 at home and 18-17 on the road. For the season, they are hitting .243, but they are actually hitting better on the road (.265, second best behind the Cubs). They’ll be giving the ball to Emerson Hancock to start the day. Hancock is 3-2 on the year with a 4.48 ERA but has allowed three runs across three starts in June (1.53 ERA).