St. Louis Cardinals vs San Francisco Giants Prediction & Picks - MLB
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by Stephen Abiola in MLB Picks
St. Louis Cardinals (75-77) and San Francisco Giants (63-89) will close out their three-game series on Wednesday evening at Busch Stadium. The Cardinals failed to build on their 2-1 win in the series opener after losing 10-3 on Tuesday night. Their offense was largely quiet last night as this game once again exposed their defensive struggles this year. This defeat leaves them fourth in the NL Central, just half a game behind the third-placed Pirates.
San Francisco Giants, on the other side of the grass, have already been eliminated from playoff contention in the NL West. They’re fourth in the standings with a massive 17-game gap with the third-placed Diamondbacks. However, they were highly impressive last night as they snapped their four-game losing streak. San Francisco got off to a fast start, stretching their lead to 7-1 in the third. They’ll want to surprise the visitors once again tonight.
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St. Louis Cardinals vs San Francisco Giants Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
16
|
0.493 | 152 | 75 | 77 |
|
27
|
0.414 | 152 | 63 | 89 |
St. Louis Cardinals and San Francisco Giants Latest Matches
3/6 (50%)
3/6 (50%)
Sep 15, 2026 - MLB
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3/6 (50%)
3/6 (50%)
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
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Aug 30, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 9, 2026 - MLB
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Sep 4, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
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Sep 12, 2026 - MLB
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Sep 9, 2026 - MLB
3/6 (50%)
3/6 (50%)
Sep 13, 2026 - MLB
Sep 12, 2026 - MLB
Sep 11, 2026 - MLB
Sep 9, 2026 - MLB
Sep 8, 2026 - MLB
Sep 7, 2026 - MLB
2/6 (33%)
4/6 (67%)
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
Sep 6, 2026 - MLB
Sep 5, 2026 - MLB
Sep 4, 2026 - MLB
Sep 3, 2026 - MLB
St. Louis Cardinals against San Francisco Giants : Head to Head (H2H)
17 %
83 %
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
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Sep 24, 2025 - MLB
St. Louis Cardinals - San Francisco Giants Key Points
- The total runs went over 7.5 in four of the last six St. Louis Cardinals matches.
- The total runs went over 7.5 in five of the last six San Francisco Giants matches.
- The total runs went over 7.5 in six of the last seven St. Louis Cardinals home games.
- The total runs went over 7.5 in seven of the last 10 San Francisco Giants away games.
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Our St. Louis Cardinals vs San Francisco Giants Prediction
The Cardinals are the -165 betting favorites to win. They have a balanced 37-40 home record compared to the Giants’ 27-50 away record this season. However, the Giants have defeated the Cardinals in five of their last six meetings. For this reason, we’ll make a safer bet of over 7.5 runs. The starting pitchers look shaky, with Matthew Liberatore of the Cardinals entering this contest with a 5-14 record and 5.53 ERA. Anthony Molina of St. Louis is still relatively unconvincing as a starter this year despite boasting a 3-1 record. The right-hander comes into this matchup with a 5.24 ERA and gave up seven runs last time out. He’s evidently a risky choice for the visitors. We expect some offensive fireworks today.
Our prediction for St. Louis Cardinals vs San Francisco Giants: Over 7.5 runs to hit.
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