St. Louis Cardinals vs San Francisco Giants Prediction & Picks - MLB

USA - MLB

St. Louis Cardinals
9/15/26 19:45
San Francisco Giants

Prediction:

 

San Francisco Giants +1.5

-157
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 by Matt Lowrimore in MLB Picks

A full 15-game MLB slate is scheduled for Tuesday, one of which will feature a National League matchup between the St. Louis Cardinals and the San Francisco Giants. Let’s take a look at the match statistics and predictions for this game between the Cardinals and the Giants.

San Francisco enters this game having long been eliminated from the playoffs and is currently in fourth place in the National League West Division. Starting this game for the Giants will be Blade Tidwell, who has an ERA of 4.82. Tidwell has had limited experience on the road this season, but has had some success, which could carry over to this matchup with the Cardinals. 

As for St. Louis, they enter this game sitting just under .500 and are currently in fourth place in the National League Central Division. Set to start this game for the Cardinals will be Andrew Pallante, who has an ERA of 3.45. Home starts have overall been a struggle for Pallante, which could allow even the Giants to take advantage early in this game.

St. Louis Cardinals vs San Francisco Giants Form

Table

Teams Pts P W L
15 St. Louis Cardinals
0.497 151 75 76
27 San Francisco Giants
0.411 151 62 89

St. Louis Cardinals and San Francisco Giants Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants

Sep 13, 2026 - MLB

St. Louis Cardinals
3 :  1
Chicago White Sox

Sep 12, 2026 - MLB

St. Louis Cardinals
5 :  6
Chicago White Sox

Sep 11, 2026 - MLB

St. Louis Cardinals
7 :  3
Chicago White Sox

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants

Sep 13, 2026 - MLB

St. Louis Cardinals
3 :  1
Chicago White Sox

Sep 12, 2026 - MLB

St. Louis Cardinals
5 :  6
Chicago White Sox

Sep 11, 2026 - MLB

St. Louis Cardinals
7 :  3
Chicago White Sox

Aug 30, 2026 - MLB

St. Louis Cardinals
4 :  5
Pittsburgh Pirates

Aug 29, 2026 - MLB

St. Louis Cardinals
2 :  6
Pittsburgh Pirates
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals

Sep 7, 2026 - MLB

San Francisco Giants
5 :  4
St. Louis Cardinals

Sep 6, 2026 - MLB

Colorado Rockies
8 :  10
St. Louis Cardinals

Sep 5, 2026 - MLB

Colorado Rockies
10 :  7
St. Louis Cardinals

Sep 4, 2026 - MLB

Colorado Rockies
6 :  7
St. Louis Cardinals
San Francisco Giants
San Francisco Giants Latest matches
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants

Sep 13, 2026 - MLB

San Francisco Giants
4 :  6
San Diego Padres

Sep 12, 2026 - MLB

San Francisco Giants
6 :  7
San Diego Padres

Sep 11, 2026 - MLB

San Francisco Giants
5 :  7
San Diego Padres

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 13, 2026 - MLB

San Francisco Giants
4 :  6
San Diego Padres

Sep 12, 2026 - MLB

San Francisco Giants
6 :  7
San Diego Padres

Sep 11, 2026 - MLB

San Francisco Giants
5 :  7
San Diego Padres

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals

Sep 7, 2026 - MLB

San Francisco Giants
5 :  4
St. Louis Cardinals
W L L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants

Sep 6, 2026 - MLB

New York Mets
4 :  2
San Francisco Giants

Sep 5, 2026 - MLB

New York Mets
5 :  9
San Francisco Giants

Sep 4, 2026 - MLB

New York Mets
10 :  6
San Francisco Giants

Sep 3, 2026 - MLB

Pittsburgh Pirates
5 :  2
San Francisco Giants

Sep 2, 2026 - MLB

Pittsburgh Pirates
4 :  5
San Francisco Giants

St. Louis Cardinals against San Francisco Giants : Head to Head (H2H)

St. Louis Cardinals

33 %

San Francisco Giants

67 %

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals

Sep 7, 2026 - MLB

San Francisco Giants
5 :  4
St. Louis Cardinals

Sep 24, 2025 - MLB

San Francisco Giants
4 :  3
St. Louis Cardinals

Sep 23, 2025 - MLB

San Francisco Giants
8 :  9
St. Louis Cardinals
St. Louis Cardinals vs San Francisco Giants Picks

St. Louis Cardinals - San Francisco Giants Key Points

  1. Blade Tidwell has an ERA of 4.82 this season
  2. Blade Tidwell has an ERA of 3.48 on the road this season
  3. Andrew Pallante has an ERA of 3.45 this season
  4. Andrew Pallante has an ERA of 4.02 at home this season

Our St. Louis Cardinals vs San Francisco Giants Prediction

The Cardinals are the heavy favorite in this game; however, the Giants look to be the best betting option. This goes directly to the home/away splits between the two starting pitchers. Tidwell has made seven away appearances this season (three starts), in which he has allowed eight earned runs over 20.2 innings. As for Pallente, he has made 14 home starts, having allowed 38 runs (36 earned) over 80.2 innings.

In addition to Tidwell showing promise when pitching on the road, the Giants have also beaten the Cardinals in every meeting they have played against them this season (not including Monday’s game). For that reason, our St. Louis Cardinals vs. San Francisco Giants prediction is: San Francisco Giants +1.5.

Prediction:

 

San Francisco Giants +1.5

-157
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.