New York Yankees vs San Francisco Giants Prediction & Picks - MLB

Prediction published on 4/11/25, 3:36 PM  by Carlos Zabala | Modified on 2/16/26 at 4:30 PM in MLB Picks

The Yankees only managed one home run at Detroit, and they return to Yankee Stadium on Friday to kick off their weekend series against the Giants, a strong start to the 2025 season.

Giants-Yankees clashes don't happen often in MLB, but since 2016, these teams have met 10 times, and the Yankees have won eight, including a sweep in San Francisco in 2024.

Even so, betting odds for Game 1 are even, as the Giants' electrifying 9-3 start, with Robbie Ray on the mound against Stroman for the Yankees, has bookmakers and bettors thinking the winner of Game 1 could be a coin toss.

Like the Yankees, the Giants did not hit in the first two games of their last series against the Reds, being dominated by starters Greene, who pitched 8.2 innings, and then by Lodolo, who pitched another 6 scoreless innings in Game 2. However, the Giants came back from a Game 3 deficit against the Reds, where they were losing 6-1 and would eventually win 8-6 on a Yastrzemski walk-off homer.