Los Angeles Dodgers vs San Francisco Giants Prediction & Picks - MLB

Prediction published on 5/11/26, 7:02 PM  by Lou Aguila | Modified on 5/12/26 at 11:48 PM in MLB Picks

The Los Angeles Dodgers and the San Francisco Giants have averaged a combined 3.33 runs per game over their last three meetings. With the over/under for Game 1 of their fresh series set at 9.5 runs, the UNDER has emerged as a sharp play at -110.

Current Form:

The Los Angeles Dodgers now share the same 24-16 record and the No.1 spot in the NL West with the San Diego Padres after losing three of their last five games, including back-to-back 7-2 losses to the Atlanta Braves.

The San Francisco Giants have claimed two wins in their last three games to slightly improve their record to 16-24, fourth in the NL West. However, the Giants are still trying to sustain success on the road, where they are 6-12 in the season.

The Matchups:

The Giants boast a 3-1 record over the Dodgers in their last four meetings. Over their last three head-to-head faceoffs, the Giants have averaged 2.00 runs per game and held the Dodgers to 1.33 runs per contest.

The Dodgers have pitched a 3.68 ERA and averaged 4.1 runs per game on a .204 BA over their last five assignments. The Giants have a slightly elevated ERA of 5.81 and averaged 4.1 runs per game on a .236 BA over their last five games.

Starting Pitchers:

Dodgers RHP Roki Sasaki (1-3, 5.97 ERA): Sasaki has sported a 2-3 record with a 6.57 ERA over his last five starts. In his last mound appearance, the Japanese gave up 3 earned runs over six innings in a 2-3 loss to the Cardinals.

Giants RHP Trevor McDonald (1-0, 1.29 ERA): McDonald gave up one earned run over seven innings in his first start this season on May 4, leading the Giants to a 3-2 win over the Padres. McDonald also surrendered one earned run over six innings in his first faceoff against the Dodgers on September 21, 2025.

Winning 3 of their last 4 meetings against the Dodgers, the Giants seem to be an enticing moneyline pick in this series opener because of their recent head-to-head success. However, the Dodgers can always flip the switch whenever they find themselves against the wall.