Los Angeles Dodgers vs San Francisco Giants Prediction & Picks - MLB

Prediction published on 9/21/25, 12:42 PM  by Lou Aguila | Modified on 9/22/25 at 9:39 AM in MLB Picks

The Detroit Tigers will try to complete a four-game sweep of the San Francisco Giants in the final game of their series on Sunday at Dodger Stadium.

The Dodgers, 8-2 in their last 10 meetings against the Giants, are valued at -110 on a -1.5 runline.

Current Form:

The Dodgers continued their mastery over the Giants, as they rallied from a 0-4 hole to hack out a 7-5 comeback win on Saturday. With the win, Los Angeles (88-67) has padded their lead over the San Diego Padres (84-67) to four games, inching closer to locking up the NL West title. The Dodgers are 4-0 in their last four games and 8-2 in their last 10 games at home.

Saturday’s loss sent the Giants to the brink of elimination as they are now four games off a wild-card spot. San Francisco is 1-4 in their last 5 games, during which they have posted a .164 batting average while averaging 3.6 runs per game.

Pitchers Matchup:

Giants RHP Trevor McDonald (0-0, 9.00 ERA) vs. Dodgers RHP Emett Sheehan (6-3, 3.17 ERA).