Chicago Cubs vs San Francisco Giants Prediction & Picks - MLB

USA - MLB

Chicago Cubs
6/6/26 14:20
San Francisco Giants

Prediction:

 

Over 7.5 runs.

-137
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 by Stephen Abiola in MLB Picks

Chicago Cubs (33-31) and San Francisco Giants (26-38) will meet for the second time in this three-game series on Saturday evening at Wrigley Field. The Cubs suffered a major setback in Game 1 after losing 18-3 in a rain-delayed game. They held their own quite well until the fourth inning, when they were just 2-0 down. However, they collapsed and allowed the Giants to race to a 16-0 lead in the sixth, giving them zero chances of mounting a comeback. The Cubs will be keen to prove a point tonight.

San Francisco Giants, meanwhile, got a huge emotional boost after the blowout win on Friday. They bombarded the hosts with a whopping seven home runs, with Malt Chapman belting a grand slam. He also piled up a career-high of 8 RBI to help the Giants rout Chicago. Interestingly, this is the second straight game that the Giants have scored 12+ runs after defeating the Brewers 12-9 on Thursday.

Chicago Cubs vs San Francisco Giants Form

Table

Teams Pts P W L
12 Chicago Cubs
0.516 64 33 31
26 San Francisco Giants
0.406 64 26 38

Chicago Cubs and San Francisco Giants Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
W L L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 5, 2026 - MLB

Chicago Cubs
3 :  18
San Francisco Giants

Jun 4, 2026 - MLB

Chicago Cubs
7 :  6
Athletics

Jun 3, 2026 - MLB

Chicago Cubs
4 :  5
Athletics

Jun 2, 2026 - MLB

Chicago Cubs
1 :  2
Athletics

May 31, 2026 - MLB

St. Louis Cardinals
5 :  1
Chicago Cubs

May 30, 2026 - MLB

St. Louis Cardinals
1 :  6
Chicago Cubs
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Jun 5, 2026 - MLB

Chicago Cubs
3 :  18
San Francisco Giants

Jun 4, 2026 - MLB

Chicago Cubs
7 :  6
Athletics

Jun 3, 2026 - MLB

Chicago Cubs
4 :  5
Athletics

Jun 2, 2026 - MLB

Chicago Cubs
1 :  2
Athletics

May 24, 2026 - MLB

Chicago Cubs
5 :  8
Houston Astros

May 23, 2026 - MLB

Chicago Cubs
0 :  3
Houston Astros
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 31, 2026 - MLB

St. Louis Cardinals
5 :  1
Chicago Cubs

May 30, 2026 - MLB

St. Louis Cardinals
1 :  6
Chicago Cubs

May 29, 2026 - MLB

St. Louis Cardinals
6 :  5
Chicago Cubs

May 28, 2026 - MLB

Pittsburgh Pirates
2 :  7
Chicago Cubs

May 27, 2026 - MLB

Pittsburgh Pirates
4 :  10
Chicago Cubs

May 26, 2026 - MLB

Pittsburgh Pirates
12 :  1
Chicago Cubs
San Francisco Giants
San Francisco Giants Latest matches
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 5, 2026 - MLB

Chicago Cubs
3 :  18
San Francisco Giants

Jun 4, 2026 - MLB

Milwaukee Brewers
9 :  12
San Francisco Giants

Jun 3, 2026 - MLB

Milwaukee Brewers
0 :  1
San Francisco Giants

Jun 2, 2026 - MLB

Milwaukee Brewers
8 :  3
San Francisco Giants

Jun 1, 2026 - MLB

Milwaukee Brewers
16 :  2
San Francisco Giants

May 31, 2026 - MLB

Colorado Rockies
6 :  19
San Francisco Giants
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 27, 2026 - MLB

San Francisco Giants
2 :  3
Arizona Diamondbacks

May 26, 2026 - MLB

San Francisco Giants
5 :  7
Arizona Diamondbacks

May 25, 2026 - MLB

San Francisco Giants
2 :  6
Arizona Diamondbacks

May 24, 2026 - MLB

San Francisco Giants
8 :  5
Chicago White Sox

May 23, 2026 - MLB

San Francisco Giants
10 :  3
Chicago White Sox

May 22, 2026 - MLB

San Francisco Giants
4 :  9
Chicago White Sox
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 5, 2026 - MLB

Chicago Cubs
3 :  18
San Francisco Giants

Jun 4, 2026 - MLB

Milwaukee Brewers
9 :  12
San Francisco Giants

Jun 3, 2026 - MLB

Milwaukee Brewers
0 :  1
San Francisco Giants

Jun 2, 2026 - MLB

Milwaukee Brewers
8 :  3
San Francisco Giants

Jun 1, 2026 - MLB

Milwaukee Brewers
16 :  2
San Francisco Giants

May 31, 2026 - MLB

Colorado Rockies
6 :  19
San Francisco Giants

Chicago Cubs against San Francisco Giants : Head to Head (H2H)

Chicago Cubs

0 %

San Francisco Giants

100 %

Jun 5, 2026 - MLB

Chicago Cubs
3 :  18
San Francisco Giants

Mar 8, 2026 - MLB Spring Training

Chicago Cubs
5 :  9
San Francisco Giants

Feb 22, 2026 - MLB Spring Training

San Francisco Giants
4 :  2
Chicago Cubs

Aug 28, 2025 - MLB

San Francisco Giants
4 :  3
Chicago Cubs

Aug 27, 2025 - MLB

San Francisco Giants
12 :  3
Chicago Cubs

Aug 26, 2025 - MLB

San Francisco Giants
5 :  2
Chicago Cubs

Chicago Cubs - San Francisco Giants Key Points

  1. The total runs went over in five of the last six San Francisco Giants matches.
  2. The total runs went over 7.5 in seven of the last eight San Francisco Giants matches.
  3. The total runs went over 7.5 in three of the last four Chicago Cubs matches.
  4. The total runs went over 7.5 in 12 of the last 13 San Francisco Giants away games.

Our Chicago Cubs vs San Francisco Giants Prediction

The Cubs are the warm -160 favorites. They’ll start Ben Brown, who will be keen to improve his 2-2 record with a 1.92 ERA this season. However, we cannot trust the Cubs to win after dropping nine of their last 10 games. Their 1-9 record against the Giants in the last 10 games also doesn’t fill us with much confidence. We’ll, therefore, choose over 7.5 runs to hit. The Giants have been scoring and giving away lots of runs lately, averaging 8.00 runs and 7.25 opponent runs in their last eight matches. The visitors are also in great form, going 4-2 in their last six matches with a similar record on the road. They’ll start Landen Roupp (4.22 ERA), who has solid numbers, although he doesn’t offer the same level of reliability as Brown.

Our prediction for Chicago Cubs vs San Francisco Giants: Over 7.5 runs.

Prediction:

 

Over 7.5 runs.

-137
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Chicago Cubs vs San Francisco Giants Picks