Chicago Cubs vs San Francisco Giants Prediction & Picks - MLB

USA - MLB

Chicago Cubs
5/6/25 19:40
San Francisco Giants

Prediction:

 

Cubs -1.5 Runs

+145
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 by Lou Aguila | in MLB Picks

The San Francisco Giants will go for an equalizer as they attempt to recover from an embarrassing series-opening loss to the Chicago Cubs in Tuesday’s Game 2 at Wrigley Field.

The Giants absorbed a huge 2-9 loss to the Cubs in Game 1 of their series. San Francisco, 12th in the MLB with 166 runs, could only score two runs as the Cubs hurler completely smothered them from start to finish. With the loss, the Giants’ record dropped to 22-14, third in the NL West standings.

The Cubs reinforced their position atop the NL Central with the win on Tuesday. Chicago is currently the No.1 scoring team in the MLB, averaging 6.1 runs per game on a .263 batting average this season. The Cubs are mid in terms of pitching, but they will be sending probably their most consistent pitcher this season in Colin Rea (2-0, 1.46 ERA) to the mound in Game 2.

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Chicago Cubs vs San Francisco Giants Form

Table

Teams Pts P W L
6 Chicago Cubs
0.568 162 92 70
16 San Francisco Giants
0.5 162 81 81

Chicago Cubs and San Francisco Giants Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 4, 2025 - MLB

Milwaukee Brewers
4 :  0
Chicago Cubs

May 3, 2025 - MLB

Milwaukee Brewers
2 :  6
Chicago Cubs

May 2, 2025 - MLB

Milwaukee Brewers
0 :  10
Chicago Cubs

May 1, 2025 - MLB

Pittsburgh Pirates
3 :  8
Chicago Cubs

Apr 30, 2025 - MLB

Pittsburgh Pirates
4 :  3
Chicago Cubs

Apr 29, 2025 - MLB

Pittsburgh Pirates
0 :  9
Chicago Cubs
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 26, 2025 - MLB

Chicago Cubs
4 :  10
Philadelphia Phillies

Apr 25, 2025 - MLB

Chicago Cubs
4 :  0
Philadelphia Phillies

Apr 23, 2025 - MLB

Chicago Cubs
7 :  6
Los Angeles Dodgers

Apr 22, 2025 - MLB

Chicago Cubs
11 :  10
Los Angeles Dodgers

Apr 19, 2025 - MLB

Chicago Cubs
6 :  2
Arizona Diamondbacks

Apr 18, 2025 - MLB

Chicago Cubs
13 :  11
Arizona Diamondbacks
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 4, 2025 - MLB

Milwaukee Brewers
4 :  0
Chicago Cubs

May 3, 2025 - MLB

Milwaukee Brewers
2 :  6
Chicago Cubs

May 2, 2025 - MLB

Milwaukee Brewers
0 :  10
Chicago Cubs

May 1, 2025 - MLB

Pittsburgh Pirates
3 :  8
Chicago Cubs

Apr 30, 2025 - MLB

Pittsburgh Pirates
4 :  3
Chicago Cubs

Apr 29, 2025 - MLB

Pittsburgh Pirates
0 :  9
Chicago Cubs
San Francisco Giants
San Francisco Giants Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 3, 2025 - MLB

San Francisco Giants
6 :  3
Colorado Rockies

May 2, 2025 - MLB

San Francisco Giants
4 :  0
Colorado Rockies

May 1, 2025 - MLB

San Francisco Giants
3 :  4
Colorado Rockies

Apr 30, 2025 - MLB

San Diego Padres
5 :  3
San Francisco Giants

Apr 29, 2025 - MLB

San Diego Padres
7 :  4
San Francisco Giants

Apr 27, 2025 - MLB

San Francisco Giants
3 :  2
Texas Rangers
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 3, 2025 - MLB

San Francisco Giants
6 :  3
Colorado Rockies

May 2, 2025 - MLB

San Francisco Giants
4 :  0
Colorado Rockies

May 1, 2025 - MLB

San Francisco Giants
3 :  4
Colorado Rockies

Apr 27, 2025 - MLB

San Francisco Giants
3 :  2
Texas Rangers

Apr 25, 2025 - MLB

San Francisco Giants
0 :  2
Texas Rangers

Apr 24, 2025 - MLB

San Francisco Giants
6 :  5
Milwaukee Brewers
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 30, 2025 - MLB

San Diego Padres
5 :  3
San Francisco Giants

Apr 29, 2025 - MLB

San Diego Padres
7 :  4
San Francisco Giants

Apr 20, 2025 - MLB

Los Angeles Angels
5 :  4
San Francisco Giants

Apr 19, 2025 - MLB

Los Angeles Angels
2 :  3
San Francisco Giants

Apr 18, 2025 - MLB

Los Angeles Angels
2 :  0
San Francisco Giants

Apr 17, 2025 - MLB

Philadelphia Phillies
6 :  4
San Francisco Giants

Chicago Cubs against San Francisco Giants : Head to Head (H2H)

Chicago Cubs

33 %

San Francisco Giants

67 %

Jun 27, 2024 - MLB

San Francisco Giants
3 :  5
Chicago Cubs

Jun 26, 2024 - MLB

San Francisco Giants
4 :  3
Chicago Cubs

Jun 25, 2024 - MLB

San Francisco Giants
5 :  1
Chicago Cubs

Jun 24, 2024 - MLB

San Francisco Giants
5 :  4
Chicago Cubs

Jun 19, 2024 - MLB

Chicago Cubs
6 :  5
San Francisco Giants

Jun 17, 2024 - MLB

Chicago Cubs
6 :  7
San Francisco Giants

Chicago Cubs - San Francisco Giants Key Points

  1. San Francisco is 1-6 SU in its last 7 games on the road.
  2. San Francisco is 1-6 SU in its last 7 games when playing on the road against Chicago Cubs.
  3. Chicago Cubs is 4-1 SU in its last 5 games.
  4. Chicago Cubs is 6-1 SU in its last 7 games when playing at home against San Francisco.
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Our Chicago Cubs vs San Francisco Giants Prediction

Fearless Forecast: Cubs’ offense stays hot, beats the Giants again

On Tuesday, we have a terrific matchup on the mound when Colin Rea duels with former CY Young Winner Justin Verlander (1-4, 3.94 ERA). After a slow start to his Giants stint, Verlander has slowly stabilized his numbers, giving up just 4 earned runs across 3 games. Unfortunately, the Giants have gone 0-4 in his last four starts. On the other hand, Rea has powered the Cubs to a victory in his last four trips on the mound. The Cubs have also won by at least two runs in these wins, which bodes well for bettors who picked Chicago to beat the -1.5 run handicap. Our betting prediction for Chicago Cubs vs. San Francisco Giants: Cubs -1.5 Runs

Prediction:

 

Cubs -1.5 Runs

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Chicago Cubs vs San Francisco Giants Picks